Method for preparing biological composite coating on surface of magnesium-based material

A composite coating and base material technology, applied in coatings, electrolytic coatings, anodic oxidation, etc., can solve problems such as different degradation mechanisms, achieve improved corrosion resistance, good biocompatibility and biological activity, and strong corrosion resistance sexual effect

Active Publication Date: 2011-12-07
BEIJING JINGCI PERMANENT MAGNETIC TECH DEV CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

At present, some people have combined chitosan and calcium-phosphorus compounds to prepare bioactive materials. Because of their different degradation mechanisms, the combination of enzymatic ch

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of calcium phosphorus ceramic / chitosan bioactive coating on the surface of AZ91 magnesium alloy by micro-arc oxidation-electrodeposition. The specific implementation steps are as follows:

[0029] a) AZ91 surface pretreatment: The magnesium alloy base material is polished, degreased and cleaned in sequence, and set aside.

[0030] b) Micro-arc oxidation treatment: immerse the magnesium-based base material treated in step a) into a solution containing 0.05mol / L Na 3 PO 4 , 0.02mol / L Na 2 SiO 3 , 0.025mol / L NaOH, 0.002mol / L Ca(NO 3 ) 2 In the micro-arc oxidation electrolyte, the surface is ceramicized by energizing under stirring at room temperature.

[0031] c) Electrochemical deposition: immerse the micro-arc oxidation sample formed in step b) in a solution containing 0.05mol / LCa(NO 3 ) 2 , 0.04mol / LNH 4 h 2 PO 4 , 0.04mol / LNaNO 3 and 5% chitosan solution 2mL, adjust pH4.9, current density 2.5mA / cm 2 , Deposition time 1h at 45°C.

[0032] d) T...

Embodiment 2

[0035]Except changing electrodeposition condition in embodiment 1 to: 0.03mol / LCa (NO 3 ) 2 , 0.02mol / LNH 4 h 2 PO 4 , 0.03mol / LNaNO 3 and 2mL of 3% chitosan solution, except for adjusting the pH to 3.8, the other treatments remained unchanged.

[0036] The phase composition of the obtained calcium phosphorus ceramic / chitosan bioactive coating was analyzed by XRD, and whether the structure of the electrodeposited layer changed before and after chitosan was added. SEM was used to observe the surface morphology of the micro-arc oxidation film and the calcium-phosphorus ceramic coating before and after adding chitosan, and analyze the effect of chitosan on changing the crystal shape of the film layer by comparison. The biological activity of the film layer was evaluated by soaking in simulated body fluid, and the Ca in the solution after soaking for different time was tested by atomic absorption photometer. 2+ Concentration changes, so as to preliminarily analyze its biolo...

Embodiment 3

[0038] With embodiment 1, only change 5% chitosan solution 3mL, current density 5mA / cm 2 , 1.5h deposition time at 60°C, other treatments were the same as in Example 1.

[0039] The phase composition of the obtained calcium phosphorus ceramic / chitosan bioactive coating was analyzed by XRD, and whether the structure of the electrodeposited layer changed before and after chitosan was added. SEM was used to observe the surface morphology of the micro-arc oxidation film and the calcium-phosphorus ceramic coating before and after adding chitosan, and analyze the effect of chitosan on changing the crystal shape of the film layer by comparison. The biological activity of the film layer was evaluated by soaking in simulated body fluid, and the Ca in the solution after soaking for different time was tested by atomic absorption photometer. 2+ Concentration changes, so as to preliminarily analyze its biological activity.

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Abstract

The invention discloses a method for preparing a biological composite coating on the surface of a magnesium-based material, and the method comprises the following steps of: after the magnesium-based material is pre-treated, placing the magnesium-based material in an electrolyte containing Na3PO4 and Ca(NO3)2 for micro-arc oxidation treatment to obtain a ceramic film layer; then placing the material with the micro-arc oxidation film layer in an electrodeposition solution to carry out electrodeposition reaction at a constant voltage for 0.1-2 hours, wherein the electrodeposition solution comprises 0.1 mol/L Ca(NO3)2, 0.06 mol/L NH4H2PO4, 0.04 mol/L NaNO3 and 3-5% chitosan solution, and the pH value is adjusted to be 3.8-4.9; and after electrodeposition, taking out the material, rinsing and drying. In the method disclosed by the invention, chitosan is added to calcium phosphate ceramic coated on the micro-arc oxidation film layer, thereby the structure of the calcium phosphate deposited layer can be significantly changed, and ultimately a calcium phosphate/chitosan composite and hybrid is formed. The obtained biological composite coating has excellent corrosion resistance, biological activity and compatibility as well as good adhesion with the magnesium metal substrate, and can be used as a new bone substitute material.

Description

technical field [0001] The invention relates to a method for preparing a biological composite coating on the surface of a magnesium-based material, belonging to the field of biomedical material preparation. Background technique [0002] Biomaterials are materials that treat organisms and replace damaged tissues and organs or enhance their functions. With the development of material science, life science and biotechnology, more and more biological materials have been widely used, among which metal materials, bioceramic materials, polymer materials, polymers and their composite materials are the most widely used biological materials. In recent years, commonly used bone substitutes are metals, plastics, and ceramics, among which titanium and titanium alloys are the main ones. However, since metal is a biologically inert material, the combination with bone is only a mechanical locking method, which will cause problems such as wear and component diffusion. Therefore, in tissue ...

Claims

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Application Information

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IPC IPC(8): C25D11/30C25D9/00A61L27/40
Inventor 邵忠财姜海涛王爽
Owner BEIJING JINGCI PERMANENT MAGNETIC TECH DEV CO LTD
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