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Medical porous polyether-ether-ketone with drug loading function and preparing method and application thereof

A polyether ether ketone, a technology for a manufacturing method, applied in the field of medical drug-carrying porous polyether ether ketone and the preparation thereof, can solve the problems of insufficient bonding, ineffective implants, easy detachment of coatings, etc. The effect of low manufacturing cost, excellent mechanical properties, and easy operation

Active Publication Date: 2016-12-07
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] These methods have indeed improved the biological activity of PEEK, but the combination of biologically active substances and polyetheretherketone is not tight enough, causing the coating to fall off easily during implantation and application, so that the implant cannot achieve the desired effect

Method used

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  • Medical porous polyether-ether-ketone with drug loading function and preparing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A titanium wire with a diameter of 0.05mm is used to wind and weave it into a set shape with a porosity of 10%. The molten polyether ether ketone is injected into the pores of porous titanium through die casting, and then hydrofluoric acid with a concentration of 10% is passed. Corroded for 12 hours, a porous polyether ether ketone with a pore size of 0.05mm and a porosity of 90% was formed. The laser cladding method was used to load tantalum powder in the pores. Tantalum has excellent biocompatibility and can effectively improve the osseointegration ability of the material . The compressive yield strength of the material is 1MPa, and the elastic modulus is 0.1GPa, which is suitable for bone repair and bone implantation under non-stressed conditions.

Embodiment 2

[0034] A titanium wire with a diameter of 0.2mm is used to wind and weave it into a set shape with a porosity of 30%. The molten polyether ether ketone is injected into the pores of porous titanium through die casting, and then hydrofluoric acid with a concentration of 10% is passed. Corrosion for 8 hours to form a porous polyetheretherketone with a pore size of 0.2 mm and a porosity of 70%. The hydroxyapatite slurry is loaded in the pores and then solidified. The hydroxyapatite has excellent biocompatibility and can promote implantation The body forms a firm bond with the bone. The compressive yield strength of the material is 10MPa, and the elastic modulus is 2GPa, which is suitable for bone repair and bone implantation under non-stressed conditions.

Embodiment 3

[0036] A titanium wire with a diameter of 0.4mm is used to wind and weave it into a set shape with a porosity of 50%. The molten polyether ether ketone is injected into the pores of porous titanium through die casting, and then hydrofluoric acid with a concentration of 10% is passed After being corroded for 8 hours, a porous polyetheretherketone with a pore size of 0.4mm and a porosity of 50% is formed, and its appearance is as follows: figure 1 As shown, the embedding method was used to load vancomycin in the wells. Vancomycin is a commonly used clinical antibiotic at present. The chance of implant surgery failing. The material has a compressive yield strength of 30MPa and an elastic modulus of 5GPa, making it suitable for bone repair and bone implantation under stress loading.

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Abstract

The invention relates to medical porous polyether-ether-ketone with a drug loading function and a preparing method and application thereof. The medical porous polyether-ether-ketone has a uniform porous structure or gradient change type porous structure, pore size is 0.05-2 mm, and porosity is 10-90%. During preparation, molten polyether-ether-ketone is extruded into preform pores through pressure casting, and then preform is etched off with the chemical method to form the porous polyether-ether-ketone. The material has excellent mechanical property, and pore size and porosity are controllable. The porous structure of the material can be loaded with drugs to prevent infection and promote bone growth and healing. Compared with the prior art, the medical porous polyether-ether-ketone with the drug loading function and the preparing method and application thereof have the advantages that operation is easy, structure is controllable, drug loading is convenient, drug binding is firm, and cost is low.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a medical drug-loadable porous polyether ether ketone and a preparation method thereof. The prepared material is mainly used in artificial joints, spinal fusion, bone repair, bone transplantation and the like. Background technique [0002] Polyether ether ketone has good mechanical properties, chemical stability and biocompatibility, and can withstand steam and radiation sterilization. Therefore, polyetheretherketone medical materials have been widely used in clinical applications. As a biologically inert material, polyether ether ketone is difficult to form bone fusion with human bones, which limits its application as a bone repair material. [0003] In response to this deficiency, many scholars have applied different methods to process PEEK to improve its osteogenic performance; including: PEEK-hydroxyapatite (HA) composite material, PEEK-HA-carbon fiber composi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/56A61L27/54A61L27/50
CPCA61L27/18A61L27/50A61L27/54A61L27/56A61L2300/102A61L2300/104A61L2300/112A61L2300/406A61L2300/414A61L2430/02C08L61/16
Inventor 何国李秋炎
Owner SHANGHAI JIAO TONG UNIV
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