31results about How to "Modulated release rate" patented technology

The invention provides an anti-infection biological ceramic artificial bone and application thereof. The artificial bone is prepared by the following method that biological ceramics, bioglass sintering auxiliary agents and bonding agents are mixed; the obtained mixture is formed to obtain a composite blank body; the bioglass sintering auxiliary agents are selected from silicate glass and/or phosphate glass; antibacterial ions and bone vascularization promotion ions are mixed in the bioglass sintering auxiliary agents; the antibacterial ions are selected from one or several kinds of materials from silver, gallium, copper and zinc; the bone vascularization promotion ions are selected from one or several kinds of materials from magnesium, strontium, iron, boron, cobalt and lithium; the total amount of substances of oxides of the antibacterial ions and oxides of the bone vascularization promotion ions accounts for 0.1 to 60 percent of the amount of substance of the bioglass sintering auxiliary agents; the mol ratio of the antibacterial ions to the bone vascularization promotion ions is (0.05 to 20):1; the composite blank body is sintered to obtain the biological ceramic artificial bone. The anti-infection biological ceramic artificial bone has the advantages of high intensity and low cell toxicity; the antibacterial ion release speed is controllable; the release time is long.

The invention relates to a preparation method of a polydopamine microcapsule oral insulin administration carrier. The preparation method comprises the following steps: dissolving insulin powder in an acidic solution, adding sodium chloride, and preparing insulin micro/nano particles by a salting-out process; dispersing the insulin micro/nano particles in a dopamine weakly-alkaline solution, and reacting under oscillation conditions to obtain a polydopamine-coated insulin core-shell structure; and finally, dispersing the polydopamine-coated insulin core-shell structure in a functional molecule solution, and modifying functional molecules on the surface, thereby obtaining the biocompatible polydopamine microcapsule oral insulin administration carrier capable of overcoming the intestinal tract barrier. The polydopamine microcapsule oral insulin administration carrier has the p-responsive insulin release behavior, has the advantages of favorable cell compatibility and the like, can overcome the intestinal tract barrier, and can be used for treating diabetes.

The invention belongs to the technical field of biomedicines, and particularly relates to a double-drug loaded thixotropic hydrogel for tumor local treatment and a preparation method thereof. The thixotropic hydrogel can be used for treating tumors by local injection including but not limited to intratumor injection, peritumoral injection and the like), and comprises the following components in percentage by mass: 1.2-18 percent of silk fibroin and 0.2-8 percent of hydroxy propyl cellulose, wherein the mass ratio of silk fibroin to hydroxy propyl cellulose is 1.5-9; and the anti-cancer medicament comprises 60-1900 mu g/mL curcumin and 10-3200 mu g/mL of doxorubicin hydrochloride. The drug loaded hydrogel has thixotropic syringeability and long-time drug sustained-release effect.

The invention relates to a long-acting nitrogen fertilizer containing nitrogen-fixing microorganisms. The long-acting nitrogen fertilizer is prepared from the following raw materials in parts by weight: 45 to 60 parts of urea, 2 to 6 parts of extract liquid of a urease inhibitor, 15 to 30 parts of humic acid, 10 to 20 parts of amino acid powder, 4 to 8 parts of extract liquid of a nitrification inhibitor, 4 to 8 parts of amino acid liquid, 0.5 to 1.5 parts of microorganism bacterial powder, 0.08 to 0.4 part of polyglutamic acid and 3.6 to 7.6 parts of glucosaminoglycan. According to the nitrogen fertilizer disclosed by the invention, the nitrogen-fixing microorganisms are combined with the nitrification inhibitor and the urease inhibitor, and various factors for regulating and controlling fixing and release of nitrogen are compounded and combined according to a scientific proportion and coating level, so that nitrogen release is effectively regulated and controlled, and nitrogen is guaranteed to be long-acting and effective.

The invention provides a bone repair material and a preparation method thereof. The material comprises hydrogel and magnesium-containing micro-nano particles. The mass percentage of magnesium is 0.1-15% based on the total mass of the bone repair material of 100%. The bone repair material provided by the invention can realize the purpose of regulating and controlling the release rate of magnesium ions by regulating and controlling the crosslinking density of hydrogel and the content of groups interacting with magnesium ions. Meanwhile, the bone repair material provided by the invention has large magnesium ion release amount and long magnesium ion release time.

The invention relates to an absorbable magnesium alloy staple having antibiosis and anti-inflammation functions, and a making method thereof. The staple is composed of a pure magnesium or magnesium alloy wire core with the surface containing a porous ceramic layer, an intermediate functional layer loaded with anti-inflammation medicines and copper ions with gelatin as a carrier, and a degradable high-molecular external surface layer. The copper ions and the anti-inflammation medicines are effectively loaded on the surface of the wire with gelatin as the carrier by adopting an electrophoresis-electrodeposition process, and the external surface layer of the staple is a degradable high-molecular layer having a protection effect. The staple can slowly release the copper ions having a sterilizing effect and the anti-inflammation medicines having an anti-inflammation effect in the use process. Additionally, the synergistic effect between the intermediate functional layer with the gelatin as the carrier and the external degradable high-molecular layer realizes the effective control of the medicine release rate and the staple degradation speed. The staple can be widely applied to the stitching or inosculation of the intestine, the stomach and other human body different positions, and has a wide application prospect.

The invention discloses an intrauterine device material capable of adjusting and controlling release rate of copper ions. The material comprises copper particles, low-density polyethylene and a soluble biological material. The weight percentage of the soluble biological material accounts for 0.5-10% of the total weight of the intrauterine device material, preferably 2.5-7.5%. The soluble biological material is one or both of glucose and starch. The intrauterine device made from the intrauterine device material can greatly improve the release rate of the copper particles under the condition of constant copper particle content in the Cu/LDPE composite material IUD, the time for the Cu/LDPE composite material IUD to release the minimum copper ion concentration to inhibit sperm activity capability in uterine liquid is greatly prolonged, and therefore, the purpose for prolonging the service life of the composite material IUD is achieved.

The invention belongs to the technical field of marine antifouling materials, and particularly relates to a preparation method for self-polishing antifouling resin. The resin is a branched polymer with self-polishing performance, which is prepared by taking a double-bond-terminated polyester oligomer as a branched monomer, (methyl) acrylate as a monomer and active/controllable free radical polymerization as a means. In the using process of the resin, degradation of polyester chain segments in the resin and short primary chain length endow the resin with excellent self-polishing performance. The resin prepared by using the preparation method provided by the invention realizes self-polishing through degradation of branched chain segments in a polymer. According to the method, various functional vinyl monomers can be conveniently added into the resin preparation process to obtain self-polishing antifouling paint resin with different properties. Meanwhile, the preparation method provided by the invention is simple in operation method, low in cost and applicable to industrial production.

The invention discloses a traditional Chinese medicine composition and plaster used for treating vertebra column and vertebra lumbalis and a preparation method and application of plaster, and relatesto the field of Chinese herbal medicine. The traditional Chinese medicine composition used for treating vertebral column and vertebra lumbalis contains the following crude drugs in parts by weight: 30-50 parts of caulis spatholobi, 5-15 parts of safflower carthamus, 10-30 parts of eucommia ulmoides, 20-40 parts of rhizoma atractylodis macrocephalae, 15-25 parts of radix Clematidis, 20-40 parts ofradix paeoniae alba, 5-15 parts of frankincense, 20-40 parts of poria cocos, 10-30 parts of fructus psoraleae, 25-35 parts of papaya, 5-15 parts of myrrh, 15-25 parts of Chinese polyphaga, 15-25 partsof paniculate swallowwort root, 10-20 parts of radix angelicae pubescentis, 30-50 parts of polygonum cuspidatum, 25-35 parts of Chinese starjasmine stem, 15-25 parts of zaocys dhumnades, and 15-25 parts of radix stephaniae tetrandrae. The traditional Chinese medicine composition, by reasonable compatibility of the components, has a good treatment effect for old strain, lumbar muscle strain and vertebral column or lumbar vertebrae injuries, and is low in cost and fast to take effect.

The invention belongs to the field of phytoplankton ecological concrete, in particular to a degradable phosphate cement-based aggregate with fertilizer efficiency slow-releasing property and a preparation method thereof. The composition comprises the following components in parts by weight: 2-5 parts of molasses, 6-15 parts of soluble starch, 5-85 parts of citric acid powder, 40-55 parts of magnesium chloride, 15-25 parts of ammonium dihydrogen phosphate, 5-12 parts of glucose, 2-8 parts of sodium fatty acid, 5-10 parts of water-absorbent resin, 5-15 parts of Portland cement and 37-73 parts ofwater. As that magnesium ammonium phosphate hexahydrate is used as the main component, the pH value of the aqueous solution in the pores of the aggregate is changed by regulating the pH value of theaggregate using citric acid, thereby obtaining the aggregate with good fertilizer effect, slow release and degradability.

The invention discloses a cabazitaxel oligo/polylactic acid coupled prodrug and a preparation method thereof. The preparation method is characterized in that cabazitaxel and oligo/polylactic acid undergo an esterification reaction under the action of a condensing agent and a catalyst to obtain the cabazitaxel oligo/polylactic acid coupled prodrug. The invention also discloses a cabazitaxel-oligo/polylactic acid coupled prodrug preparation, and a preparation method and an application thereof. The oligo/polylactic acid is covalently coupled with cabazitaxel, so the in vivo release rate of cabazitaxel is can be regulated, the precipitation of cabazitaxel, caused by strong release, is prevented, the in vivo cycle period of the cabazitaxel is prolonged, and the maximum tolerable dose is increased. The oligo/polylactic acid is approved for use by the US FDA and has an excellent application prospect. The cabazitaxel oligo/polylactic acid prodrug and an amphiphilic polymer PEG5k-PLA8k are assembled to form nanoparticles, and the nanoparticles have a passive targeting effect, and are easily retained in the tumor site by the EPR effect in order to greatly reduce the toxic and side effects ofthe drug on normal tissues.

The invention discloses a sodium nitrite-gelatin microsphere and a preparation method and application thereof. The preparation method comprises the following steps of: firstly, adding gelatin into deionized water, and stirring until the gelatin is completely dissolved to obtain a gelatin solution; then adding sodium nitrite into the gelatin solution, and continuously stirring until the sodium nitrite is completely dissolved to obtain a mixed solution; then adding glutamine transaminase into the mixed solution, and then stirring for reaction to obtain a cross-linked solution; then adding an emulsifier into an oil phase, then dropwise adding the cross-linked solution under the stirring condition, and continuously carrying out emulsification reaction under the stirring condition to form an emulsion; and finally, cooling the emulsion under the stirring condition, and carrying out operations such as ultrasonic treatment, suction filtration separation and washing to finally obtain the sodium nitrite-gelatin microsphere. The preparation method is simple in overall operation, and the prepared sodium nitrite-gelatin microsphere is smooth in surface and uniform in particle size, has the average particle size of 5-40 microns, can slowly release NO in a weak acidic environment, and can be applied to food antibacterial agents.