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High-strength hydrogel

A hydrogel, high-strength technology, applied in prosthesis, medical science, etc., can solve problems such as impact on application and low mechanical strength

Inactive Publication Date: 2013-06-05
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its good biocompatibility, hydrogel is considered to be the most potential scaffold material for tissue engineering, but usually its low mechanical strength seriously affects its application in tissue engineering.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0020] Example 1: Dissolve 0.5 g of sodium hyaluronate (HA) in 100 mL of phosphate buffer solution (PBS, pH 7.4), add 50 mL of N,N-dimethylformamide, and then sequentially add 2.52 g of triethylamine and 3.54 g glycidyl methacrylate, stirred at room temperature for 5 days. Concentrate, dialyze, and lyophilize to obtain double-bond functionalized hyaluronic acid (HAGMA); dissolve 2 g of PEG with a number average molecular weight of 20,000 g / mol into a 100-ml round-bottomed flask filled with 50 ml of toluene at 135 °C Under reflux for 4 hours, a small amount of water was removed by azeotropic distillation. After the toluene solution is cooled to room temperature, add 0.13 g of sodium carbonate, stir in an ice bath for 30 minutes, then slowly drop 0.1 mL of acryloyl chloride dissolved in 10 ml of tetrahydrofuran into the flask, and react in an ice bath for 30 minutes , react overnight at 45°C. After the reaction was completed, it was filtered with suction, concentrated and repr...

Embodiment 2

[0021] Example 2: Dissolve 0.5 g of sodium polyglutamate (PGA) in 20 mL of phosphate buffer solution (PBS, pH 7.4), then add 2.52 g of dimethylaminopyridine and 3.54 g of glycidyl methacrylate in sequence, and stir at room temperature 5 days. Concentrate, dialyze, and lyophilize to obtain double-bond functionalized sodium polyglutamate (PGAGMA); dissolve 2 g of PEG with a number average molecular weight of 20,000 g / mol into a 100 mL round-bottomed flask containing 50 mL of toluene , 135 degrees Celsius under reflux for 4 hours, azeotropic distillation to remove traces of water. After the toluene solution is cooled to room temperature, add 0.13 g of sodium carbonate, stir in an ice bath for 30 minutes, then slowly drop 0.1 mL of acryloyl chloride dissolved in 10 ml of tetrahydrofuran into the flask, and react in an ice bath for 30 minutes , react overnight at 45°C. After the reaction was completed, it was filtered with suction, concentrated and reprecipitated in excess ether,...

Embodiment 3

[0022] Example 3: Dissolve 0.5 g of sodium chondroitin sulfate (CS) in 50 mL of phosphate buffer solution (PBS, pH 7.4), add 50 mL of N,N-dimethylformamide, and then add 2.52 g of triethylamine in sequence and 3.54 g glycidyl methacrylate, stirred at room temperature for 5 days. Concentrate, dialyze, and lyophilize to obtain double-bond functionalized chondroitin sulfate sodium (CSGMA); dissolve 2 g of PEG with a number-average molecular weight of 20,000 g / mol into a 100-mL round-bottomed flask containing 50 mL of toluene, Reflux at 135 degrees Celsius for 4 hours, and remove a small amount of water by azeotropic distillation. After the toluene solution is cooled to room temperature, add 0.13 g of sodium carbonate, stir in an ice bath for 30 minutes, then slowly drop 0.1 mL of acryloyl chloride dissolved in 10 ml of tetrahydrofuran into the flask, and react in an ice bath for 30 minutes , react overnight at 45°C. After the reaction was completed, it was filtered with suction...

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Abstract

The invention discloses a novel high-strength hydrogel which is prepared by the following steps: synthesizing a first network hydrogel from a polyelectrolyte (such as hyaluronate, polyglutamic acid, chondroitin sulfate or polylysine); and after soaking the hydrogel in a double-bond functional polyethyleneglycol water solution for some time, taking out, and crosslinking to obtain the high-strength double-network hydrogel. The synthesized high-strength hydrogel has favorable biocompatibility, can be used as a tissue engineering / repair scaffold material or the like, and has wide applicability in the field of biomedical materials.

Description

technical field [0001] The invention relates to the synthesis of a class of high-strength hydrogel and belongs to the field of polymer materials. Background technique [0002] In recent decades, with the wide application prospects of polymer materials in the diagnosis and treatment of diseases and the repair or replacement of biological tissues and organs, their research has attracted more and more attention. Due to its good biocompatibility, hydrogel is considered to be the most potential scaffold material for tissue engineering, but usually its low mechanical strength seriously affects its application in tissue engineering. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a high-strength hydrogel. [0004] The high-strength hydrogel with excellent biocompatibility provided by the present invention is to synthesize the first network hydrogel with polyelectrolyte, and the first network hydrogel is soaked in doubl...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L77/04C08L71/08C08J3/28C08J3/24C08J3/075A61L27/48A61L27/52
Inventor 廖立琼范长江刘立建
Owner WUHAN UNIV
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