Peeling composition for digestive endoscopy minimally invasive surgery

Abstract

The invention discloses a stripping composition for digestive endoscopic minimally invasive surgery, which is prepared from the following components in parts by weight: 5 to 10 parts of tissue stripping agent, 0.5 to 1.0 part of osmotic pressure regulator, 0.01 to 0.2 part of synergist, 0.01 to 0.1 part of stabilizer, 0.001 to 0.1 part of hemostatic and 0.0005 to 0.002 part of color indicator. By dissolving connective tissues under the mucous membrane, the time for stripping by using an electrotome is shortened, the surgical stripping difficulty is reduced, the surgical time is shortened, the risks of bleeding and perforation in the surgical process and postoperation delayed bleeding and perforation are reduced, and the safety is improved.

Description

Technical Field

[0001] The invention belongs to the field of medical technology, and in particular relates to a stripping composition for minimally invasive digestive endoscopic surgery. Background Art

[0002] In recent years, with the rapid development of digestive endoscopy technology, digestive endoscopy minimally invasive surgery has been widely used in the treatment of many clinical diseases. In the current clinical surgery process, the submucosal layer is fully exposed mainly by injecting lifting fluid, and then the endoscope is used to enter the submucosal space, and then the electric knife is used to achieve the removal of the submucosal layer and the diseased tissue. However, during the operation, since the connective tissue around the diseased tissue needs to be separated, the separation process is prone to complications such as bleeding and perforation. Therefore, it is necessary to provide a peeling composition for digestive endoscopy minimally invasive surgery. Summary of the invention

[0003] The object of the present invention is to provide a stripping composition for minimally invasive endoscopic surgery, which can reduce the time of stripping using an electric knife, reduce the difficulty of surgical stripping, shorten the operation time, and reduce the risks of bleeding and perforation during surgery and delayed bleeding and perforation after surgery, thereby improving safety.

[0004] To achieve the above object, the present invention adopts the following technical solution: A stripping composition for minimally invasive digestive endoscopic surgery comprises, by weight, 5-10 parts of a tissue stripping agent, 0.5-1.0 parts of an osmotic pressure regulator, 0.01-0.2 parts of a synergist, 0.01-0.1 parts of a stabilizer, 0.001-0.1 parts of a hemostatic agent, and 0.0005-0.002 parts of a color indicator.

[0005] Furthermore, the tissue peeling agent is acetylcysteine.

[0006] Furthermore, the osmotic pressure regulator is sodium chloride.

[0007] Furthermore, the enhancer is fibrinolytic enzyme.

[0008] Furthermore, the stabilizer is at least one of calcium chloride and propylene glycol.

[0009] Furthermore, the hemostatic agent is at least one of adrenaline and norepinephrine.

[0010] Furthermore, the color indicator is methylene blue.

[0011] The significant advantages of the present invention are: (1) The stripping composition for minimally invasive endoscopic surgery provided by the present invention can play a synergistic role in the dissolution of submucosal connective tissue through the compounding of acetylcysteine ​​and fibrinolytic enzyme, and produce a blunt separation effect, which makes the wound surface visible, can more effectively pre-treat the blood vessels, reduce the risk of intraoperative bleeding, reduce the time of intraoperative hemostasis, and the submucosal stripping is not easy to damage the muscle layer, reducing the probability of intraoperative perforation; at the same time, it can reduce the time of using the electric knife to be powered on, reduce thermal damage, reduce the risk of delayed bleeding and perforation after surgery, and also reduce the occurrence of complications of electrocoagulation syndrome. Therefore, the use of the stripping composition of the present invention can reduce the difficulty of surgical stripping and shorten the operation time.

[0012] (2) The present invention adds a color indicator to the peeling composition, which can clearly indicate the surgical range, facilitate the peeling of the lesion, and reduce the risk of damaging normal tissue.

[0013] (3) The components of the exfoliation composition for minimally invasive endoscopic surgery provided by the present invention have good biosafety and can ensure the safety of patients. DETAILED DESCRIPTION

[0014] A stripping composition for minimally invasive digestive endoscopic surgery comprises, by weight, 5-10 parts of a tissue stripping agent acetylcysteine, 0.5-1.0 parts of an osmotic pressure regulator sodium chloride, 0.01-0.2 parts of a synergist fibrinolytic enzyme, 0.01-0.1 parts of a stabilizer, 0.001-0.1 parts of a hemostatic agent, and 0.0005-0.002 parts of a color indicator methylene blue.

[0015] Wherein, the stabilizer is at least one of calcium chloride and propylene glycol.

[0016] The hemostatic agent is at least one of adrenaline and norepinephrine.

[0017] In order to make the contents of the present invention easier to understand, the technical solution of the present invention is further described below in conjunction with specific implementation methods, but the present invention is not limited thereto. Example

[0018] 1. Experimental animals: 70 pigs with a weight of 32-36 kg were used as experimental animals after inspection and quarantine. The pigs were fed with sugary liquid food and water instead of dregs 2 days before the experiment.

[0019] 2. Test agents: Prepare the corresponding peeling compositions according to the formula in Table 1.

[0020] Table 1 Test drug formulation

[0021] 3. Test methods: 70 experimental animals were randomly divided into 7 groups, 10 pigs in each group, including experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, control group 1 and control group 2. Each pig underwent endoscopic submucosal dissection (ESD) at three sites of the digestive tract, namely the esophagus, stomach and intestine. The size of each surgical site was about 2 cm × 2 cm.

[0022] 4. Test steps: 1) Marking After the surgical site is determined, an electrosurgical knife is used to mark the surgical site with electrocoagulation.

[0023] 2) Submucosal injection The corresponding test drugs were respectively injected submucosally at multiple points outside the marked points at the edge of the surgical site to lift the lesion and separate it from the muscular layer.

[0024] 3) Cut Use an electric cutting knife to incise the mucosa along the lateral edge of the marked point.

[0025] 4) Separation of submucosal connective tissue The submucosal connective tissue is separated using an electrosurgical cutter. The submucosal injection fluid is gradually absorbed over time (repeated submucosal injections can be performed if necessary to maintain adequate mucosal elevation).

[0026] 5) Treatment of bleeding during surgery Intraoperative bleeding can be stopped by electrocoagulation or hemostatic forceps.

[0027] 6) Postoperative wound treatment After the operation, electrocoagulation was performed on the visible bleeding points on the wound surface to stop bleeding.

[0028] 5. Evaluation indicators of the test (1) Submucosal connective tissue separation time; (2) the number of hemostasis during the separation of submucosal connective tissue; (3) The number of injections and the amount of samples used in the control group and the experimental group during the separation of submucosal connective tissue.

[0029] 6. Test results Table 2

[0030] The results in Table 2 show that during endoscopic minimally invasive surgery, the time for separation of submucosal connective tissue using the stripping composition containing acetylcysteine ​​and fibrinolytic enzyme is significantly shorter than that using the composition containing only acetylcysteine, which fully demonstrates that the stripping composition containing fibrinolytic enzyme can improve the efficiency of endoscopic minimally invasive surgery, and can reduce the number of hemostasis times during the separation of submucosal connective tissue, and reduce the number of injections and usage during the separation of submucosal connective tissue; at the same time, the use of hemostatic agents and osmotic pressure regulators helps to further improve the efficiency of endoscopic minimally invasive surgery and shorten the operation time.

[0031] The above description is only a preferred embodiment of the present invention. All equivalent changes and modifications made according to the scope of the patent application of the present invention should fall within the scope of the present invention.

Claims

1. A peeling composition for minimally invasive digestive endoscopic surgery, characterized in that: By weight, the stripping composition comprises 5-10 parts of tissue stripping agent, 0.5-1.0 parts of osmotic pressure regulator, 0.01-0.2 parts of synergist, 0.01-0.1 parts of stabilizer, 0.001-0.1 parts of hemostatic agent, and 0.0005-0.002 parts of color indicator.

2. The exfoliation composition for minimally invasive endoscopic surgery according to claim 1, characterized in that: The tissue peeling agent is acetylcysteine.

3. The exfoliation composition for minimally invasive endoscopic surgery according to claim 1, characterized in that: The osmotic pressure regulator is sodium chloride.

4. The exfoliation composition for minimally invasive endoscopic surgery according to claim 1, characterized in that: The enhancer is fibrinolytic enzyme.

5. The exfoliation composition for minimally invasive endoscopic surgery according to claim 1, characterized in that: The stabilizer is at least one of calcium chloride and propylene glycol.

6. The exfoliation composition for minimally invasive digestive endoscopic surgery according to claim 1, characterized in that: The hemostatic agent is at least one of adrenaline and norepinephrine.

7. The exfoliation composition for minimally invasive digestive endoscopic surgery according to claim 1, characterized in that: The color indicator is methylene blue.

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