New application of patchoulenone and derivative thereof

A technology of patchouli ketone and derivatives, applied in the direction of medical preparations, applications, and biocides containing active ingredients, which can solve the problems of drug resistance and large side effects, achieve good antibacterial activity, and have a good clinical application prospect , the effect of overcoming drug resistance of pathogenic bacteria

Active Publication Date: 2014-02-12
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the commonly used drugs for bacterial infectious diseases are antibiotics and broad-spectrum antibacterial drugs, such as imipenem, secondly citioperazone-sulbactam, vancomycin, and secondly nitrofurantoin, which have large side effects and will cause Develop drug resistance, leading to superbugs

Method used

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  • New application of patchoulenone and derivative thereof
  • New application of patchoulenone and derivative thereof
  • New application of patchoulenone and derivative thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Antibacterial activity of patchouli ketone

[0037] 1Materials and instruments

[0038] 1.1 Experimental instrument

[0039] Multi-point inoculation apparatus (Japan Sakuma Manufacturing Co., Ltd., SAKUMA MIT-P type), electric heating constant temperature water bath (Beijing Tonghua Medical Instrument Factory, DSY-1-6 hole), laboratory autoclave (SANYO, MLS- Type 3780), CO 2 INCUBATOR (SANYO, MOC-15A), energy-saving purification workbench (Chengdu Xinguang Feilante Purification Engineering Co., Ltd.).

[0040] 1.2 Experimental strains

[0041] Staphylococcus aureus ATCC25923; Methicillin-resistant Staphylococcus aureus ATCC43300; Escherichia coli ATCC25922.

[0042] The above standard quality control strains are provided by Sichuan Antibiotic Industry Research Institute.

[0043] Staphylococcus haemolyticus, Staphylococcus xylosus, Megacoccus escherichia, Staphylococcus saprophyticus, Staphylococcus auricula, Corynebacterium dryis, Staphylococcus aureus, Aeromonas caviae...

Embodiment 2

[0066] Example 2 Antibacterial activity of patchouli ketone in vivo

[0067] 1 Experimental materials

[0068] 1.1 Drugs

[0069] The test drug, patchouli ketone;

[0070] Positive drug, penicillin sodium for injection, specification: 800,000 units, North China Pharmaceutical Co., Ltd., batch number: Y1104101; Vancomycin hydrochloride for injection, specification: 500,000 units, Zhejiang Pharmaceutical Co., Ltd. Xinchang Pharmaceutical Factory, batch number: 111204; Cefotaxime sodium for injection, specification: 1.0g, North China Pharmaceutical Hebei Huamin Pharmaceutical Co., Ltd., batch number: XF3120707.

[0071] Modeling drug: Mucin form Porcine Stomach (TypeⅡ), specification: 100g, SIGMA-ALDRICH, batch number: 018K0079.

[0072] 1.2 Strains

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PUM

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Abstract

The invention provides an application of patchoulenone or a derivative thereof in preparing medicines for treating bacterial infectious diseases. Furthermore, the invention provides a pharmaceutical composition for treating the bacterial infectious diseases. The patchoulenone has an excellent activity on inhibiting pathogenic bacteria such as staphylococcus and opportunistic pathogenic bacteria, and can effectively treat bacterial infectious diseases; and the patchoulenone can effectively inhibit methicillin-resistant drug-resistance bacteria, thus providing a new choice for clinical medication.

Description

Technical field [0001] The invention relates to a new use of patchoulione and its derivatives, in particular to the use in the preparation of drugs for treating bacterial infectious diseases. Background technique [0002] Bacterial infectious diseases refer to diseases caused by bacterial infections. Among the common clinical pathogens, there are more Gram-negative bacteria, such as Escherichia, Enterobacter and Pseudomonas bacteria, and Gram-positive bacteria, such as Staphylococcus and intestine Coccus bacteria. [0003] At present, most commonly used drugs for bacterial infectious diseases are antibiotics and broad-spectrum antibacterial drugs, such as imipenem, second-selected sulbactam, vancomycin, and second-selected nitrofurantoin, which have large side effects and will cause large-scale use. The development of drug resistance leads to the emergence of super bacteria. Methicillin-resistant Staphylococcus aureus is a kind of super bacteria, which is only sensitive to vanco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P31/04A23L33/00
CPCA61K31/366A61Q17/005A23L3/3499A61K8/498A01N49/00A23L1/3002A23L33/105A61K36/53A61P31/02A61P31/04A61P31/10Y02A50/30
Inventor 彭成万峰熊亮林大胜
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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