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Novel application of patchouli alcohol

A kind of bocicol, a technology of use, applied in the field of medicine, to achieve good inhibitory activity, slow down or avoid the effect of drug-resistant bacteria

Active Publication Date: 2013-06-05
CHENGDU HUASUN GRP INC LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the use of bocicol in the treatment of bacterial infectious diseases

Method used

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  • Novel application of patchouli alcohol
  • Novel application of patchouli alcohol
  • Novel application of patchouli alcohol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 100

[0023] The in vitro bacteriostatic activity research of embodiment 1 buccal alcohol

[0024] 1 Materials and Instruments

[0025] 1.1 Experimental Instruments

[0026] Multi-point inoculation instrument (Japan Sakuma Manufacturing Co., Ltd., SAKUMA MIT-P type), electric heating constant temperature water bath (Beijing Tonghua Medical Instrument Factory, DSY-1-6 holes), laboratory autoclave (SANYO, MLS- 3780), CO 2 INCUBATOR (SANYO, MOC-15A), energy-saving purification workbench (Chengdu Xinguang Feilante Purification Engineering Co., Ltd.).

[0027] 1.2 Experimental strains

[0028] ① Quality control strains: Staphylococcus aureus ATCC 29213; Staphylococcus aureus ATCC 25923; Staphylococcus aureus ATCC 43300; Staphylococcus epidermidis ATCC 12228; Enterococcus faecium ATCC 33186; Enterococcus faecalis ATCC 29212; ) ATCC 51299; Streptococcus pneumoniae ATCC 49619; Escherichia coli ATCC 25922; Klebsiella pneumoniae ATCC 700603. The above standard quality control strains wer...

Embodiment 2 100

[0060] The in vivo antibacterial activity of embodiment 2 buccal alcohol

[0061] 1 Experimental materials

[0062] 1.1 Drugs

[0063] The test drug, bocicol (PC);

[0064] Positive drug, vancomycin hydrochloride for injection, specification: 500,000 units, Zhejiang Pharmaceutical Co., Ltd. Xinchang Pharmaceutical Factory, batch number: 111204;

[0065] Modeling drug: Mucin form Porcine Stomach (Type Ⅱ), specification: 100g, SIGMA-ALDRICH, batch number: 018K0079.

[0066] 1.2 Strains

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Abstract

The invention relates to application of patchouli alcohol in preparing medicines treating bacteria infectious diseases and further provides a medicine composition treating the bacteria infectious diseases. The patchouli alcohol has excellent inhibitory activity to pathogenic bacteria or conditional pathogenic bacteria and can effectively treat the bacteria infectious diseases, meanwhile, the patchouli alcohol can also effectively resist methicillin-resistant staphylococcus epidermidi drug-resistance bacteria, the pharmacodynamics activity of the patchouli alcohol equals to vancomycin, and therefore probability is provided for slowing or avoiding occurring of the drug-resistance bacteria.

Description

technical field [0001] The invention relates to a new application of bocicol, which belongs to the field of medicines. Background technique [0002] Bacterial infectious disease is a systemic infection caused by pathogenic bacteria or conditional pathogenic bacteria invading the blood circulation to grow and reproduce, producing toxins and other metabolites. It has always been regarded as an extremely dangerous disease until Alexander Fleming accidentally discovered it in 1928. After the discovery of penicillin and its clinical use, a major breakthrough was made in the fight against infectious diseases. However, with the widespread use of antibiotics, the harm of antibiotic abuse is far beyond people's imagination: Jevons in the United Kingdom discovered methicillin-resistant Staphylococcus aureus (MRSA) for the first time. Since its discovery, MRSA has infected almost all over the world and has become a hospital One of the important pathogens of infection. Studies have fo...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61P31/04A61P31/06
CPCA61K31/045A61P31/02A61P31/04A61P31/06Y02A50/30
Inventor 彭成万峰熊亮林大胜唐正伟
Owner CHENGDU HUASUN GRP INC LTD
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