Plaster containing anilinoprofen and composition

By developing a topical patch combining aniline profen and alamod, the problem of insufficient symptom relief in the treatment of orthopedic inflammatory diseases has been solved. It has achieved significant inhibition of osteoarthritis and rheumatoid arthritis and effective relief of muscle pain, providing a safe and effective local treatment solution.

CN121489923APending Publication Date: 2026-02-10GUANGZHOU DAGUANG PHARMA
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Patent Information

Application Number
CN202512001927.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2025-11-27
Filing Date
2025-12-29
Publication Date
2026-02-10

AI Technical Summary

Technical Problem

Existing topical medications have limited effect on symptom relief in the treatment of orthopedic inflammatory diseases such as osteoarthritis and rheumatoid arthritis, especially in controlling moderate to severe inflammation. Furthermore, long-term use of oral nonsteroidal anti-inflammatory drugs poses safety risks, and topical Chinese medicine plasters have limited efficacy.

Method used

A topical patch containing a combination of anilineprofen and alamod was developed. Through local administration, it significantly inhibited joint swelling, reduced the level of pro-inflammatory factors, and improved histopathological damage. The combination of anilineprofen and alamod showed a significant synergistic effect.

Benefits of technology

It significantly inhibits joint swelling, reduces pro-inflammatory factor levels, improves articular cartilage damage, and provides good relief for muscle pain. It is especially suitable for OA/RA patients who have contraindications to oral medication or require long-term management, providing a safe and effective local treatment option.

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Abstract

The invention belongs to the technical field of medicines. The invention relates to a plaster, in particular to a plaster containing anilinoprofen and a composition. The invention provides an externally applied medicine containing anilinoprofen or a composition containing anilinoprofen and iguratimod. Pharmacodynamic studies show that the aniline-ibuprofen single-prescription plaster can treat osteoarthritis (OA) and rheumatoid arthritis (RA), can effectively inhibit arthrocele and volume increase, remarkably reduces the level of proinflammatory factors, and improves the pathological score of joint tissue. After the anilinoprofen and the iguratimod are combined for use, the curative effect is further enhanced, multiple indexes are obviously superior to those of a single drug group, and an obvious synergistic interaction effect is shown. The iguratimod and anilinoprofen compound preparation disclosed by the invention is developed in an external form such as a gel plaster for the first time, an external compound system of anilinoprofen and iguratimod is innovatively constructed, a safe, effective and convenient novel local treatment choice is provided for OA / RA patients, especially people with oral taboo or needing long-term treatment, and the iguratimod and anilinoprofen compound preparation has good clinical transformation potential and application value.
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