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Composition for treating pruritus and acne and preparation method thereof

A composition and acne technology, which is applied in the preparation of the composition, and in the field of compositions for treating skin itching and facial acne, can solve the problem of single treatment, achieve the suppression of immune response, the reduction of inflammatory response, and the reduction of concentration Effect

Active Publication Date: 2014-11-05
李泽填
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention relates to a composition for treating pruritus and youthful beans and a preparation method thereof. Compared with products in the prior art, the invention has the following characteristics: on the one hand, the formula is comprehensive, extensive and quick-acting in terms of anti-itching and anti-allergy; It is significantly higher than the existing anti-inflammatory and anti-itch topical formulations, and solves the single treatment problem of existing anti-itch formulas. On the other hand, this formula greatly reduces the cost of anti-itch drugs, further simplifies the drug production process, and makes the product stable better consistency

Method used

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  • Composition for treating pruritus and acne and preparation method thereof
  • Composition for treating pruritus and acne and preparation method thereof
  • Composition for treating pruritus and acne and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] prescription

[0035] Dexamethasone acetate: 0.01% to 0.1% (in tablet form);

[0036] Chlorpheniramine maleate: 0.1% to 0.5% (in tablet form);

[0037] Chloramphenicol: 2.5% to 10% (using chloramphenicol injection);

[0038] Compound trimoxazole: 12% to 25% (using compound tablets);

[0039] Compound ketoconazole ointment 64.4% to 85% (preferably using Pikangwang).

[0040] 2. Method of preparation and use

[0041] The technical problem to be solved by the present invention can also be further realized by the following technical solutions, and it is characterized in that the preparation method of the composition: according to the weight proportion, weigh dexamethasone acetate, chlorpheniramine maleate, compound Xinnuo Ming uses a traditional Chinese medicine high-speed pulverizer to pulverize and finely grind for 2 minutes at 25,000 rpm, and grind into fine powder; measure chloramphenicol injection, add it to compound ketoconazole ointment together with the above-me...

Embodiment 2

[0044] The composition for treating itching and acne according to claim 1, wherein the mass percentage of each component is 0.05-0.6 part of dexamethasone acetate; 0.2-0.8 part of chlorpheniramine maleate; chloramphenicol 4.5-6.5 copies; 15-20 copies of compound cotrimoxazole; 78.5-82.5 copies of compound ketoconazole ointment.

[0045] 2. Method of preparation and use

[0046] The technical problem to be solved by the present invention can also be further realized by the following technical solutions, and it is characterized in that the preparation method of the composition: according to the weight proportion, weigh dexamethasone acetate, chlorpheniramine maleate, compound Xinnuo Ming uses a traditional Chinese medicine high-speed pulverizer to pulverize and finely grind for 2 minutes at 25,000 rpm, and grind into fine powder; measure chloramphenicol injection, add it to compound ketoconazole ointment together with the above-mentioned finely ground drugs, and stir and mix Ev...

experiment example 1

[0048] Experimental Example 1 Clinical data of anti-inflammatory and antipruritic gel in the treatment of pruritus and chronic eczema

[0049] Clinical Research (1)

[0050] 1. Materials and methods

[0051] 1 General information

[0052] A total of 6600 cases were included in this study (including 1200 cases of pruritus caused by bacterial infection, 120 cases of pruritus caused by fungal infection), 120 cases of pruritus caused by virus infection, 120 cases of pruritus caused by insect bite infection, strain 120 cases of dermatitis. All 120 cases in the control group met the case selection criteria.

[0053] Refer to the diagnostic criteria for chronic eczema and pruritus in the Ministry of Health's "Clinical Guidelines for New Chinese Medicines".

[0054] 1.1 Gender and age comparison between the two groups before treatment

[0055] There were 149 males and 151 females in the treatment group, the oldest being 70 years old and the youngest being 18 years old, with an av...

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Abstract

The invention relates to a composition for treating pruritus and acne and a preparation method thereof. The composition mainly comprises, by mass, 0.01-0.1% of dexamethasone acetate, 0.1-0.5% of chlorphenamine maleate, 2.5-10% of chloramphenicol, 12-25% of compound sulfamethoxazole and 64.4-85% of compound ketoconazole ointment.

Description

technical field [0001] The invention relates to a composition, in particular to a composition for treating skin itching and acne on the face. [0002] The invention also relates to a process for the preparation of the composition. Background technique [0003] Skin itching is mainly caused by the free endings of sensory nerves at the junction of the dermis and epidermis, which are stimulated by itch-causing factors to form nerve impulses and transmit them to the cerebral cortex (somatosensory area), thereby causing itching. There are many reasons for itching, but most of them are caused by skin allergies and inflammatory reactions that stimulate the tiny nerve fibers in the dermis to generate slow-frequency nerve impulses, which cause skin itching in the sensory nerve center of the cerebral cortex. [0004] With the progress of society, the development of industry, and the deterioration of the environment, more and more people are troubled by skin diseases. In daily life, ...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61P17/04A61P17/10A61P29/00A61K31/4402A61K31/165A61K31/496A61K31/573A61K31/505
Inventor 李泽填
Owner 李泽填
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