Nerve regeneration promotion injection and preparation method thereof

A technology of nerve regeneration and injection, which is applied to nervous system diseases, pharmaceutical formulas, medical preparations containing active ingredients, etc., and can solve problems such as single nerve injury, no therapeutic effect, and large molecular weight of neurotrophic substances

Active Publication Date: 2012-08-15
赵廷宝
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large molecular weight of neurotrophic substances, they cannot penetrate the blood-brain barrier and enter the central nervous tissue, so it is difficult to exert their biological activity, and there is no report of a good therapeutic effect so far for a single drug to treat nerve damage.

Method used

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  • Nerve regeneration promotion injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Take 3000 μg of mouse nerve growth factor for injection, 200 ml of monosialotetrahexosyl ganglioside sodium injection, 200 ml of cerebroside and carnosine injection, 100 ml of mecobalamin injection, and 100 ml of dexamethasone acetate injection, and put them under sterile conditions Mix well, and divide into 6ml / branch.

Embodiment 2

[0048] Take 3200 μg of mouse nerve growth factor for injection, 210ml of monosialotetrahexosylganglioside sodium injection, 220ml of cerebroside and carnosine injection, 110ml of methylcobalamin injection, and 110ml of dexamethasone acetate injection, and put them under sterile conditions. Mix well, and divide into 6ml / branch.

Embodiment 3

[0050] Take 2800 μg of mouse nerve growth factor for injection, 190 ml of monosialotetrahexosyl ganglioside sodium injection, 180 ml of cerebroside and carnosine injection, 90 ml of mecobalamin injection, and 90 ml of dexamethasone acetate injection, and put them under sterile conditions Mix well, and divide into 6ml / branch.

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Abstract

The invention relates to a medicament for nerve regeneration promotion, and particularly to a nerve regeneration promotion injection and a preparation method thereof. The nerve regeneration promotion injection is composed of the following ingredients in proportion: 280-320 micrograms of mouse nerve growth factor for injection, 19-21ml of single sialic acid four hexose ganglioside sodium injecta, 18-22ml of cerebroside-kinin injecta, 9-11ml of mecobalamine injecta and 9-11ml of dexamethasone acetate injecta. The five effective ingredients of the medicament provided by the invention are combined together and cooperative actions of multiple nutritive factors are utilized, so that the medicament has a significant curative effect on repairing of injured nerve, especially the repairing of spinal nerve injury. The medicament provided by the invention also has a protection effect on spinal cord transected injury at the early stage.

Description

technical field [0001] The invention relates to a drug for promoting nerve regeneration, in particular to an injection for promoting nerve regeneration and a preparation method thereof. Background technique [0002] Paraplegia caused by spinal cord injury is a disease that seriously affects the quality of life of the patient. The patient loses the ability to live independently, suffers great pain physically and mentally, and also brings a huge burden to the family and society. [0003] The particularity of the central nervous system makes the research on the repair of spinal cord injury go through a long and tortuous process, and the regeneration of the damaged brain and spinal cord has therefore become the dream goal of many neuroscientists. The discovery, development and clinical application of nerve growth factors in the 1980s opened up broad prospects for clinical drug treatment of peripheral and central nervous injuries. In recent years, some new neurotrophic factors th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P25/00A61K38/17A61K31/7032A61K31/714A61K31/573
Inventor 赵廷宝刘鑫张云昌张晓君孟庆溪何帆林世德
Owner 赵廷宝
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