Method for detecting compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy

A technology of dexamethasone acetate and near-infrared spectroscopy, applied in measuring devices, material analysis through optical means, instruments, etc., can solve problems such as complex pre-processing operations and difficulty in online detection, and achieve simple operation and good stability , Real-time monitoring of the effect of concentration changes

Inactive Publication Date: 2015-03-25
CHINA RESOURCES SANJIU MEDICAL & PHARMA
View PDF6 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method realizes the simultaneous detection of the active pharmaceutical ingredients in the paint, however, t

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for detecting compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy
  • Method for detecting compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy
  • Method for detecting compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] This embodiment provides a method for online detection of the content of dexamethasone acetate in compound dexamethasone acetate cream by using near-infrared spectroscopy. The detection steps are as follows:

[0040] (1) Use a near-infrared spectrometer to collect the near-infrared spectrograms of 60 compound dexamethasone acetate cream standard products online, and select the corresponding wavenumber range of dexamethasone acetate to be 10000-4000cm -1 Spectral band of the spectral waveband is used as characteristic spectrum, carries out first-order differential and Norris smoothing preprocessing to described characteristic spectrum, obtains the near-infrared spectrogram after preprocessing (see figure 1 ), the calculation formula of the first-order differential and Norris smoothing pretreatment is as follows:

[0041] dy dx + P ( x ) y = ...

Embodiment 2

[0060] The present embodiment provides a method for online detection of menthol and camphor content in compound dexamethasone acetate cream by using near-infrared spectroscopy, and the detection steps are as follows:

[0061] (1) Collect the near-infrared spectra of 80 compound dexamethasone acetate cream standard products online with a near-infrared spectrometer, and select menthol and camphor to correspond to a wavenumber range of 10000-4000cm -1 Spectral band of the spectral waveband is used as characteristic spectrum, carries out first-order differential and Norris smoothing preprocessing to described characteristic spectrum, obtains the near-infrared spectrogram after preprocessing (see figure 1 ), the calculation formula of the first-order differential and Norris smoothing pretreatment is as follows:

[0062] dy dx + P ( x ) y = Q ...

Embodiment 3

[0093] The present invention also provides a system for on-line detection of compound dexamethasone acetate cream, such as Figure 7 As shown, it includes a cream-making tank for preparing the cream, a storage tank for storing the finished cream product, and a near-infrared spectrometer; wherein, the cream-making tank and the cream storage tank are connected by a connecting pipe, and A sampling port for the fiber probe of the near-infrared spectrometer to sample and collect data is provided on the connecting pipe at a position 1 / 3-2 / 3 of the length of the connecting pipe from the paste outlet, and preferably the sampling port is located in the The location of the center point of the connecting pipe.

[0094]The inner diameter of the sampling port is 15-18mm, and preferably 16.1nm.

[0095] It should be noted that since near-infrared spectroscopy acquires spectral data through multiple scans in a short period of time, there are relatively strict requirements on the properties ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
The inside diameter ofaaaaaaaaaa
The inside diameter ofaaaaaaaaaa
Login to view more

Abstract

The invention relates to a method for detecting effective components in a compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy, belonging to the technical field of medicine detection. The method for detecting compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy provided by the invention comprises the following steps: collecting a near infrared spectrum chart of a compound dexamethasone acetate emulsifiable paste standard substance online; carrying out data treatment on a characteristic spectrum by adopting a partial least square method; and then obtaining a predicted value of effective component content in the standard substance according to an established mathematical model so as to evaluate the quality of compound dexamethasone acetate. The method provided by the invention can be used for simultaneously determining multiple components and various indexes of a sample and is simple to operate without damaging the sample; the method can be used for achieving online real-time test and meanwhile the method is good in reproducibility and stability and less in personal error.

Description

technical field [0001] The invention relates to a method for online detection of active ingredients in compound dexamethasone acetate cream by using near-infrared spectroscopy, and belongs to the technical field of drug detection. Background technique [0002] Compound dexamethasone acetate cream (namely Sanjiupiyanping "red pack") is a compound preparation for external use, and its raw material components include dexamethasone acetate, menthol and camphor. Clinically, it can be used to treat skin pruritus, neurodermatitis, contact dermatitis, seborrheic dermatitis, eczema and other dermatological diseases. In the prescription, menthol and camphor can promote local circulation and mild anti-inflammatory, analgesic and antipruritic effects; dexamethasone acetate has anti-inflammatory and anti-allergic effects, can inhibit the proliferation of connective tissue, and reduce the permeability of capillary walls and cell membranes. Permeability, reducing inflammatory exudation, i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N21/359
Inventor 濮江李红单海东田杰马鹏岗郑英昊
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap