The invention relates to a method for logistics dispensing center work task processing and scheduling. The method comprises steps that, a first step, according to correlation of items in historical orders, storage location assigning for in-stockroom items is carried out; a second step, batch setting for out-stockroom orders in an order pool is carried out; a third step, sorter assignment for the out-stockroom orders after batch setting is carried out; and a fourth step, optimal walking paths are set for sorters. According to the method, storage optimization for items of new orders is realized according to a shipment trend of the historical orders, sorted task assigning for the sorters is carried out, optimization of the walking paths of the sorters is carried out, complex sorting work is made to be simple, work intensity is reduced, the work flow is standardized, and work efficiency is improved.