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Compound dexamethasone acetate cream and preparation method thereof

A technology of dexamethasone acetate and cream, applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve problems such as low absorption rate, influence stability of drug effect, waste of raw materials, etc., and achieve easy operation and cream properties. Stable, simple process effect

Inactive Publication Date: 2018-05-04
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But the absorption rate of existing compound dexamethasone acetate emulsifiable paste is low, is easy to cause the waste of crude drug, simultaneously, because compound recipe dexamethasone acetate emulsifiable paste is formed by water phase, oily phase and emulsifying agent, emulsifiable paste is placed for a long time Afterwards, it is easy to be unstable, and it is easy to cause the cream to lose its effectiveness due to oil-water separation. In addition, the main ingredient is not evenly distributed in the cream, which also affects the stability of the drug effect.

Method used

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  • Compound dexamethasone acetate cream and preparation method thereof
  • Compound dexamethasone acetate cream and preparation method thereof
  • Compound dexamethasone acetate cream and preparation method thereof

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preparation example Construction

[0049] According to one aspect of the present invention, a kind of preparation method of compound dexamethasone acetate cream, described method comprises the following steps:

[0050] (a) Fully dissolve the water-based auxiliary material in water to prepare the water phase, and keep it warm at 70-75°C for use; meanwhile, fully mix the oil-based auxiliary material at 70-75°C to prepare Prepare the oil phase and keep it warm at 70-75°C for later use;

[0051] (b), dimethyl sulfoxide is divided into two parts on average, the first part of dimethyl sulfoxide dissolves dexamethasone acetate and 2.6-di-tert-butyl p-cresol, and the second part of dimethyl sulfoxide dissolves camphor and menthol;

[0052] (c) Fully mix the water-based auxiliary materials and oil-based auxiliary materials prepared in step (a) at a temperature of 70-75°C, and add dexamethasone acetate and 2.6-di-tert-butyl Stir and homogenize the first part of dimethyl sulfoxide of p-cresol, then cool down to 40-45°C ...

Embodiment 1

[0063] A compound dexamethasone acetate cream, in parts by weight, said compound dexamethasone acetate cream is mainly made of the following components: 0.05 parts of dexamethasone acetate, 15 parts of water-based auxiliary materials, 10 parts of oil-based auxiliary materials 1 part, 1 part of dimethyl sulfoxide, 0.1 part of 2.6-di-tert-butyl-p-cresol, 1 part of camphor, 1 part of menthol and 155 parts of water;

[0064] The water-based auxiliary material comprises edetate disodium, ethylparaben, propylene glycol, triethanolamine and carbomer; the mass ratio of the above-mentioned edetate disodium, ethylparaben, propylene glycol, triethanolamine and carbomer is ,0.01:0.1:15:0.5:0.3;

[0065] The oil-based excipients include stearic acid, pinpinga, stearyl alcohol and cetyl alcohol; the mass ratio of the stearic acid, pinpinga, stearyl alcohol and cetyl alcohol is 5:1:1:1.

[0066] The preparation method of above-mentioned compound dexamethasone acetate cream comprises the fol...

Embodiment 2

[0071] A compound dexamethasone acetate cream, in parts by weight, said compound dexamethasone acetate cream is mainly made of the following components: 0.3 parts of dexamethasone acetate, 20 parts of water-based auxiliary materials, 18 parts of oil-based auxiliary materials 3 parts of dimethyl sulfoxide, 0.5 parts of 2.6-di-tert-butyl-p-cresol, 5 parts of camphor, 5 parts of menthol and 170 parts of water;

[0072] The water-based auxiliary material comprises edetate disodium, ethylparaben, propylene glycol, triethanolamine and carbomer; the mass ratio of the above-mentioned edetate disodium, ethylparaben, propylene glycol, triethanolamine and carbomer is ,0.03:0.3:16:0.8:0.6;

[0073] The oil-based excipients include stearic acid, pinpinga, stearyl alcohol and cetyl alcohol; the mass ratio of the stearic acid, pinpinga, stearyl alcohol and cetyl alcohol is 7:3:3:3;

[0074] The preparation method of the compound dexamethasone acetate cream of this embodiment is the same as ...

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Abstract

The invention provides compound dexamethasone acetate cream and a preparation method thereof and relates to the technical field of drug preparations. The compound dexamethasone acetate cream disclosedby the invention mainly comprises dexamethasone acetate, a water-based ingredient, an oil-based ingredient, dimethyl sulfoxide, 2,6-ditertbutyl-4 methylphenol, camphor, menthol and water. The compound dexamethasone acetate cream prepared from the previous components does not have any irritation or allergy to human skin, has the advantages of being moderate in viscosity and easy to apply, is excellent in moisturizing effect and is favorable for drug utilization. Moreover, the stability is high, and the main drug ingredient has uniform distribution and stable quality in the cream.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a compound dexamethasone acetate cream and a preparation method thereof. Background technique [0002] Compound dexamethasone acetate cream is a skin medicine for external use, which has significant curative effect on localized pruritus, neurodermatitis, contact dermatitis, seborrheic dermatitis and chronic eczema. [0003] But the absorption rate of existing compound dexamethasone acetate emulsifiable paste is low, is easy to cause the waste of crude drug, simultaneously, because compound recipe dexamethasone acetate emulsifiable paste is formed by water phase, oily phase and emulsifying agent, emulsifiable paste is placed for a long time Afterwards, it is easy to be unstable, and it is easy to make the cream lose its effect due to oil-water separation. In addition, the uneven distribution of the main ingredients in the cream also affects the stability of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/573A61K31/045A61K31/125A61K31/10A61K47/10A61K47/20A61P17/04A61P17/00A61P25/00A61P17/08
CPCA61K9/06A61K9/0014A61K31/045A61K31/10A61K31/125A61K31/573A61K47/10A61K47/20A61K2300/00
Inventor 龙涛王凤梅勇杨莉李林霞袁开超朱锋唐攀陈波左娟
Owner 重庆希尔安药业有限公司
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