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Compound dexamethasone acetate nano-cream and preparation method therefor

A technology of dexamethasone acetate and nanoemulsion, which is applied in the field of medicine, can solve the problems of urgent improvement of transdermal effect, and achieve the effect of improving bioavailability, good effect, and good spreadability

Inactive Publication Date: 2016-06-01
GUANGZHOU BAIYUNSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The smearability and transdermal effect of the compound dexamethasone acetate cream in the prior art need to be improved urgently

Method used

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  • Compound dexamethasone acetate nano-cream and preparation method therefor
  • Compound dexamethasone acetate nano-cream and preparation method therefor
  • Compound dexamethasone acetate nano-cream and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A compound dexamethasone acetate nano-emulsion, the proportioning relation of its raw material composition is as table 1.

[0025] Table 1

[0026] raw material

[0027] Dexamethasone acetate

[0028] The preparation method of compound dexamethasone acetate nano-emulsion, it is carried out according to the following steps: get dexamethasone acetate 0.075g, oleic acid 0.5g, caprylic capric acid macrogolglyceride 4.875g, propylene glycol 1.875g , stir to make dexamethasone acetate dissolve, under stirring condition, drop into 3.0g pure water, stir and make to form clear and transparent system, obtain dexamethasone acetate nano-emulsion, for subsequent use; Get mono-distearin 4g, ten Octalol 7g, light liquid paraffin 4g, white petrolatum 4g, heated in a water bath to 95°C, stirred to mix evenly, as the oil phase; take 1g sodium lauryl sulfate, 1g polyethylene glycol octylphenyl ether, 3.5g of glycerin, 0.1g of ethylparaben, 0.15g of 3480 essence, about...

Embodiment 2

[0030] A compound dexamethasone acetate nano-emulsion, the proportioning relation of its raw material composition is as table 2.

[0031] Table 2

[0032] raw material

[0033] The preparation method of compound dexamethasone acetate nano-emulsion, it is carried out by the steps described below: get dexamethasone acetate 0.1g, oleic acid 1g, caprylic capric acid polyethylene glycol glyceride 6g, propylene glycol 2g, stir to make Dexamethasone acetate dissolves, under stirring condition, drips into 11g pure water, stirs and makes to form clear and transparent system, obtains dexamethasone acetate nano-emulsion, for subsequent use; Get mono-distearin 4g, stearyl alcohol 7g, Light liquid paraffin 4g, white petrolatum 4g, heated to 95°C in a water bath, stirred to mix evenly, as the oil phase; take 1g sodium lauryl sulfate, 1g polyethylene glycol octylphenyl ether, 3.5g glycerin, 0.1g of ethylparaben, 0.15g of 3480 essence, about 57g of pure water, stir to disperse the ...

Embodiment 3

[0035] A compound dexamethasone acetate nano-emulsion, the proportioning relation of its raw material composition is as table 3.

[0036] table 3

[0037] raw material

[0038] The preparation method of compound dexamethasone acetate nano-emulsion, it is carried out by the steps described below: get dexamethasone acetate 0.05g, oleic acid 1g, caprylic capric acid polyethylene glycol glyceride 9g, propylene glycol 3g, stir to make Dexamethasone acetate dissolves, under stirring condition, drips into 7g pure water, stirs and makes to form clear and transparent system, obtains dexamethasone acetate nano-emulsion, for subsequent use; Get mono-distearin 4g, stearyl alcohol 7g, Light liquid paraffin 4g, white petrolatum 4g, heated to 95°C in a water bath, stirred to mix evenly, as the oil phase; take 1g sodium lauryl sulfate, 1g polyethylene glycol octylphenyl ether, 3.5g glycerin, 0.1g of ethylparaben, 0.15g of 3480 essence, about 57g of pure water, stir to disperse the ...

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Abstract

The invention discloses compound dexamethasone acetate nano-cream and a preparation method therefor. The cream comprises the following raw materials: dexamethasone acetate, camphor, menthol, a surfactant, a cosurfactant, an oil phase, a cream base material and water. The preparation method for the compound dexamethasone acetate nano-cream comprises the following steps: dissolving dexamethasone acetate in the oil phase, the surfactant and the cosurfactant, and uniformly mixing with the water to obtain nano (micro) emulsion; dispersing camphor, menthol and the nano-emulsion in the cream base and mixing uniformly to obtain the compound dexamethasone acetate nano-cream. The compound dexamethasone acetate nano-cream has the advantages of good smearing property and good transdermal effect.

Description

technical field [0001] The invention relates to a compound dexamethasone acetate nano cream and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Compound dexamethasone acetate cream (trade names sold in the domestic market are "Sanjiu Piyanping, Shunfeng Kangping", etc.) is a compound preparation for external use, which can be used clinically to treat skin pruritus, neurodermatitis, Contact dermatitis, seborrheic dermatitis, eczema and other skin diseases. The main components of compound dexamethasone acetate cream are dexamethasone acetate, camphor and menthol, and the auxiliary materials are: stearic acid, white petrolatum, stearyl alcohol, glycerin, sodium lauryl sulfate, ethylparaben Methyl sulfoxide, purified water, etc. Among them, dexamethasone acetate is an adrenal cortex hormone drug, which has anti-inflammatory and anti-allergic effects, and can reduce and prevent tissue responses to inflammation, thereby re...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K9/06A61K47/14A61K47/10A61K47/34A61P17/00A61P17/04A61P17/08A61P29/00A61P37/08A61K31/125A61K31/045
Inventor 李楚源杨燕忠徐月红曾维东邓慧敏黄杰伟梅芬罗双辉
Owner GUANGZHOU BAIYUNSHAN PHARM CO LTD
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