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Compound dexamethasone acetate gel and preparation method thereof

A technology of dexamethasone acetate and gel, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc.

Active Publication Date: 2010-11-03
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the cumulative sales of Piyanping have reached several billion yuan, and tens of millions of patients have been treated. It is a commonly used and standing external skin preparation for the majority of patients. A new dosage form that is more convenient and has a longer-lasting effect is of great significance

Method used

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  • Compound dexamethasone acetate gel and preparation method thereof
  • Compound dexamethasone acetate gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] Embodiment 1: compound dexamethasone acetate gel

[0138] Dexamethasone acetate 0.75kg

[0139] Camphor 10kg

[0140] Menthol 10kg

[0141] Propylene glycol 120kg

[0142] Ethylparaben 1kg

[0143] Absolute ethanol 16kg

[0144] Polysorbate 80 150kg

[0145] Hypromellose 5kg

[0146] Carbomer 10kg

[0147] Bright blue 0.009kg

[0148] Triethanolamine 5kg;

[0149] Take menthol and camphor, blend together, and set aside; take purified water, heat to 85°C, add hypromellose to dissolve in purified water, stir and cool to form hypromellose colloidal solution; take brilliant blue, add Dissolve in purified water; dissolve triethanolamine in purified water and set aside; take propylene glycol, add carbomer, stir until the carbomer is completely wetted, add purified water, and stir until translucent carbomer colloidal solution; triethanolamine solution Add it to the carbomer colloidal solution and stir evenly; take dexamethasone acetate and ethylparaben and dissolve i...

Embodiment 2

[0150] Embodiment 2: Compound dexamethasone acetate gel

[0151] Dexamethasone acetate 0.75kg

[0152] Camphor 10kg

[0153] Menthol 10kg

[0154] Propylene glycol 120kg

[0155] Ethylparaben 1kg

[0156] Absolute ethanol 16kg

[0157] Polysorbate 80 150kg

[0158] Hypromellose 4kg

[0159] Carbomer 8kg

[0160] Bright blue 0.009kg

[0161] Triethanolamine 4kg;

[0162] Take menthol and camphor, blend together, and set aside; take purified water, heat to 75°C, add hypromellose to dissolve in purified water, stir and cool to form hypromellose colloidal solution; take brilliant blue, add Dissolve in purified water; dissolve triethanolamine in purified water and set aside; take propylene glycol, add carbomer, stir until the carbomer is completely wetted, add purified water, and stir until translucent carbomer colloidal solution; triethanolamine solution Add it to the carbomer colloidal solution and stir evenly; take dexamethasone acetate and ethylparaben and dissolve it...

Embodiment 3

[0163] Embodiment 3: Compound dexamethasone acetate gel

[0164] Dexamethasone acetate 0.75kg

[0165] Camphor 10kg

[0166] Menthol 10kg

[0167] Propylene glycol 160kg

[0168] Ethylparaben 1kg

[0169] Absolute ethanol 16kg

[0170] Polysorbate 80 220kg

[0171] Hypromellose 5kg

[0172] Carbomer 10kg

[0173] Bright blue 0.009kg

[0174] Triethanolamine 3.8kg;

[0175] Take menthol and camphor, blend together, and set aside; take purified water, heat to 90 ° C, add hypromellose to dissolve in purified water, stir and cool to form hypromellose colloidal solution; take brilliant blue, add Dissolve in purified water; dissolve triethanolamine in purified water and set aside; take propylene glycol, add carbomer, stir until the carbomer is completely wetted, add purified water, and stir until translucent carbomer colloidal solution; triethanolamine solution Add it to the carbomer colloidal solution and stir evenly; take dexamethasone acetate and ethylparaben and dissol...

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Abstract

The invention discloses a compound dexamethasone acetate gel preparation, a preparation method thereof, a pH value check method and a relevant substance check method. The gel is prepared from the raw materials of dexamethasone acetate, camphor, menthol, propylene glycol, absolute ethyl alcohol, polysorbate 80, hydroxypropyl methylcellulose, Carbomer, triethanolamine and optionally ethyl hydroxy benzoate and / or brilliant blue. The compound dexamethasone acetate gel belongs to a replacement product of compound dexamethasone acetate cream, and has therapeutical effects on regional pruritus, neurodermatitis, contact dermatitis, seborrhoeic dermatitis and chronic eczema. Compared with the compound dexamethasone acetate cream, the gel has the advantages of better dispersibility, strong adhesion, high stability, long-lasting drug action, convenient operation, easy cleaning and the like.

Description

technical field [0001] The invention relates to a gel and a preparation method thereof, a pH inspection method and a related substance inspection method, in particular to a compound dexamethasone acetate gel and a preparation method thereof, a pH inspection method and a related substance inspection method. Background technique [0002] Skin diseases are mostly treated with local rubbing and external preparations, such as tinctures, lotions, paints and coatings, ointments and creams, pastes, etc. Piyanping (compound dexamethasone acetate cream) is Sanjiu Medicine The leading product of the Co., Ltd. for many years, after more than ten years of clinical application, Piyanping has definite curative effect, few side effects, and controllable quality. It has been included in the second volume of "Chinese Pharmacopoeia". Since Piyanping came out in the 1990s, it has been welcomed by patients because of its definite curative effect and high safety. So far, the cumulative sales of ...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K31/125A61K31/045A61K9/00A61K47/34A61K47/38A61K47/18A61K47/32G01N27/26G01N30/02A61P17/00A61P17/04A61P17/08A61K47/26
Inventor 何健赵枫林韩正洲谈英谭沛马舒冰
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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