4 results about "Drug overdose" patented technology

The application provides a non-contact pain monitoring mattress and system based on multi-modal physiological signal fusion, the mattress body comprises, from bottom to top, a bottom support layer, a signal shielding layer, a sensing core layer and a breathable skin-friendly layer, the system comprises the non-contact pain monitoring mattress, a low-noise charge amplifier, a fiber demodulator, an edge computing gateway and a cloud analysis center, the data after signal conditioning is transmitted to the edge computing gateway and uploaded to the cloud analysis center, and the cloud analysis center performs quantitative scoring through a tumor-specific pain model.The application has the advantages that no electrode or wearable device needs to be pasted, the skin irritation and psychological burden of traditional monitoring are completely eliminated, the patient compliance is improved, the limitation of subjective evaluation is broken through, an objective pain evaluation method is provided for patients in the late stage / aphasia, multi-modal signal fusion monitoring is used to effectively distinguish pain from ordinary emotional fluctuations, the degree of pain is fed back in real time, the doctor is assisted in dynamically adjusting the dose of analgesic drugs, and the risk of drug overdose and deficiency is reduced.

In some embodiments, the present invention discloses a method for treating drug overdose, comprising administering a therapeutically effective amount of a respiratory stimulant to a patient in need, wherein the overdose drug comprises an α2-adrenergic receptor agonist.

The application discloses a TENS and iontophoresis composite closed-loop analgesic patch, and belongs to the field of medical devices. The patch comprises a flexible substrate, a multi-modal sensor array, a transcutaneous electrical nerve stimulation unit, an iontophoresis drug delivery unit, a control module and a multi-level safety control unit. The sensor array collects surface electromyography signals and cutaneous electric response signals, and the control module calculates a pain probability value and executes a hierarchical control strategy: standby when the pain probability value is below a first threshold value, only activate the TENS unit when the pain probability value reaches or exceeds the first threshold value but is below a second threshold value, and simultaneously activate the TENS unit and the iontophoresis drug delivery unit after dose safety confirmation when the pain probability value reaches or exceeds the second threshold value. The multi-level safety control unit comprises a dose counter and a sensor detachment detection module, which are used for preventing drug overdose and accidental triggering. The application combines physical analgesia and chemical analgesia, realizes double analgesic effects of "instant + continuous", and guarantees the safety of home use through a multi-level safety mechanism.

The application provides a digoxin microtablet and a preparation method thereof. The digoxin microtablet prepared by the application contains 5-100 micrograms of digoxin per tablet, which can meet the dosage requirements of patients of different ages, realize precise dosage administration, and reduce the risk of drug overdose in clinical application. The digoxin microtablet provided by the application can solve the problem that infants and children have difficulty in swallowing the medicine, thereby improving the medication compliance of infants and children. Compared with conventional tablets, the microtablet has a smaller volume. The digoxin microtablet provided by the application is prepared by optimizing the prescription and process, preparing a digoxin compound by a spray drying and hot melt extrusion technology, obtaining a solid dispersion, and having better content uniformity and dissolution rate, and significantly improving the bioavailability.