The present application provides a kind of
ticagrelor pharmaceutical composition, the composition includes
ticagrelor and pharmaceutically acceptable carrier, the weight percentage of the
ticagrelor is 10%-20%, the pharmaceutically acceptable carrier is selected from any one or combination of binder, disintegrant,
diluent,
lubricant,
glidant, the weight percentage of the disintegrant is 10%-30%.The present application significantly reduces the dynamic disintegration time and static disintegration time of tablet by scientific screening and optimization of the formulation of
solid pharmaceutical composition, facilitate the rapid absorption of
drug in patients, avoid
intubation simplify clinical
medication regimen, in addition, it is convenient for patients with
dysphagia to take
medicine, significantly improve the compliance of patients to take
medicine, optimize the particle size and particle
powder properties of ticagrelor, solve the problem of large tablet
weight difference and poor content uniformity caused by poor flowability of ticagrelor after tabletting, improve the uniformity, effectiveness and safety of the
drug, realize the controllable quality of
drug.