Hydroxyapatite nanorod biological coating and preparation method thereof

A hydroxyapatite and biological coating technology, which is applied in the fields of nano-drugs, coatings, nano-technology, etc., can solve the problems of preparing HA nano-rod biological coatings that have not been reported, and achieves improved biocompatibility and improved biological Compatibility, effect of reducing cytotoxicity
CN112226767AActive Publication Date: 2021-01-15XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2021-01-15

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Abstract

The invention relates to a hydroxyapatite nanorod biological coating and a preparation method thereof. The method comprises the steps: step 1, placing zinc or a zinc alloy in an aqueous solution of calcium acetate to be subjected to a hydrothermal reaction, and placing the aqueous solution of calcium acetate in a reaction kettle, wherein zinc or the zinc alloy is in contact with the bottom of thereaction kettle, and a zinc oxide nanorod coating is formed on the surface, in contact with the bottom of the reaction kettle, of the zinc or zinc alloy; adding an aqueous solution of NaOH into an aqueous solution of calcium salt and phosphate to form a mixed system A to enable the mixed system A to be alkaline, and putting the aqueous solution of calcium salt and phosphate into the reaction kettle; and step 2, placing the zinc or zinc alloy obtained in the step 1 in the mixed system A, placing the zinc oxide nanorod coating upward, performing hydrothermal treatment at 70-180 DEG C to form a hydroxyapatite nanorod biological coating which is firm in combination and good in biological activity on the surface of the zinc oxide nanorod coating. The hydroxyapatite nanorod biological coating isof great significance in development of the zinc alloy in repairing and replacing hard tissues and applying an implant.
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Description

Technical field

[0001] The invention belongs to the technical field of zinc and zinc alloy surface treatment, and specifically relates to a hydroxyapatite nanorod biological coating and a preparation method thereof.Background technique

[0002] Studies have shown that zinc, as an essential trace element for the human body, can promote the proliferation of osteoblasts, inhibit the formation of osteoclasts, and stimulate the formation and mineralization of new bone. Zinc and its alloys have good mechanical properties and degradability, and have broad application prospects in the field of orthopedic repair and cardiovascular stents. However, Zn2+Accumulate in the local environment, causing significant cytotoxicity. Therefore, control Zn2+The large release of Zn is the key to reduce the toxicity of Zn implants and improve its biocompatibility. In order to achieve this goal, a uniform hydroxyapatite nanorod biocoating can be prepared on the surface of zinc and zinc alloy. The coating has stabl...

Claims

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