Hydroxyapatite nanorod biological coating and preparation method thereof

A hydroxyapatite and biological coating technology, which is applied in the fields of nano-drugs, coatings, nano-technology, etc., can solve the problems of preparing HA nano-rod biological coatings that have not been reported, and achieves improved biocompatibility and improved biological Compatibility, effect of reducing cytotoxicity

Active Publication Date: 2021-01-15
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, although there are a lot of reports on the preparation of HA nanorod biocoatings on other metal surfaces (such as titanium alloys) by hydrothermal method, there is no report on the preparation of HA nanorod biocoatings on the surface of zinc and zinc alloys.

Method used

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  • Hydroxyapatite nanorod biological coating and preparation method thereof
  • Hydroxyapatite nanorod biological coating and preparation method thereof
  • Hydroxyapatite nanorod biological coating and preparation method thereof

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preparation example Construction

[0034]The method for preparing HA nanorod bio-coating on the surface of zinc and zinc alloy of the present invention includes the following steps:

[0035]Step 1: Use deionized water as the solvent and calcium acetate as the solute to form a solution with a calcium acetate concentration of 0.023-0.17mol / L, and place a polished round zinc or zinc alloy with a thickness of 2mm and a diameter of 10mm A hydrothermal treatment with a temperature of 90℃-130℃ and a time of 60-240min is carried out in the solution. For the convenience of description, the zinc or zinc alloy is recorded as the matrix, and a layer of zinc oxide nanorod coating is formed on the back of the matrix. That is, the side where the substrate is in contact with the reactor, and calcium acetate is used as a stabilizer to prevent the upper surface of the substrate from being corroded and still maintain its original morphology, and finally ZnO nanorods are grown on the back side.

[0036]Step 2: Use deionized water as solvent, ...

Embodiment 1

[0039]Step 1: Use deionized water as the solvent and calcium acetate as the solute. The calcium acetate concentration is 0.034mol / L to form a hydrothermal solution. The polished zinc flakes are placed in an aqueous solution for hydrothermal treatment. The reaction temperature is 110°C. The reaction time is 180 minutes to obtain the zinc oxide nanorod coating. Refer to the SEM photo of its surface microstructurefigure 1 , It can be seen that the surface is a uniform nanorod-like structure, please refer to the contact angle photofigure 2 , Through calculation, the surface contact angle is 18.3°, the XRD pattern can be referred toPicture 10, From the XRD peak, it can be known that the main phases are Zn and ZnO.

[0040]Step 2: Use deionized water as the solvent, EDTA-Ca and diammonium hydrogen phosphate as solutes, where the concentration of EDTA-Ca is 0.167 mol / L, the concentration of diammonium phosphate is 0.1 mol / L, and the NaOH solution of 10mom / L is used Adjust the pH of the soluti...

Embodiment 2

[0042]Step 1: Use deionized water as the solvent and calcium acetate as the solute. The calcium acetate concentration is 0.034mol / L to form a hydrothermal solution. The polished zinc flakes are placed in an aqueous solution for hydrothermal treatment. The reaction temperature is 110°C. The reaction time is 180 minutes to obtain the zinc oxide nanorod coating.

[0043]Step 2: Use deionized water as the solvent, EDTA-Ca and diammonium hydrogen phosphate as solutes, where the concentration of EDTA-Ca is 0.167 mol / L, the concentration of diammonium phosphate is 0.1 mol / L, and the NaOH solution of 10mom / L is used Adjust the pH of the solution to 12.70 to form a second-step hydrothermal solution. Place the zinc alloy with zinc oxide nanorods in the solution for the second-step hydrothermal reaction. The reaction temperature is 110°C and the reaction time is 60min. The reaction is over Then, HA nanorod coating was obtained on the surface of the zinc alloy. Refer to the SEM photo of its surfac...

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Abstract

The invention relates to a hydroxyapatite nanorod biological coating and a preparation method thereof. The method comprises the steps: step 1, placing zinc or a zinc alloy in an aqueous solution of calcium acetate to be subjected to a hydrothermal reaction, and placing the aqueous solution of calcium acetate in a reaction kettle, wherein zinc or the zinc alloy is in contact with the bottom of thereaction kettle, and a zinc oxide nanorod coating is formed on the surface, in contact with the bottom of the reaction kettle, of the zinc or zinc alloy; adding an aqueous solution of NaOH into an aqueous solution of calcium salt and phosphate to form a mixed system A to enable the mixed system A to be alkaline, and putting the aqueous solution of calcium salt and phosphate into the reaction kettle; and step 2, placing the zinc or zinc alloy obtained in the step 1 in the mixed system A, placing the zinc oxide nanorod coating upward, performing hydrothermal treatment at 70-180 DEG C to form a hydroxyapatite nanorod biological coating which is firm in combination and good in biological activity on the surface of the zinc oxide nanorod coating. The hydroxyapatite nanorod biological coating isof great significance in development of the zinc alloy in repairing and replacing hard tissues and applying an implant.

Description

Technical field[0001]The invention belongs to the technical field of zinc and zinc alloy surface treatment, and specifically relates to a hydroxyapatite nanorod biological coating and a preparation method thereof.Background technique[0002]Studies have shown that zinc, as an essential trace element for the human body, can promote the proliferation of osteoblasts, inhibit the formation of osteoclasts, and stimulate the formation and mineralization of new bone. Zinc and its alloys have good mechanical properties and degradability, and have broad application prospects in the field of orthopedic repair and cardiovascular stents. However, Zn2+Accumulate in the local environment, causing significant cytotoxicity. Therefore, control Zn2+The large release of Zn is the key to reduce the toxicity of Zn implants and improve its biocompatibility. In order to achieve this goal, a uniform hydroxyapatite nanorod biocoating can be prepared on the surface of zinc and zinc alloy. The coating has stabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C26/00A61L27/04A61L27/30A61L27/32A61L27/50B82Y5/00B82Y30/00B82Y40/00
CPCC23C26/00A61L27/047A61L27/32A61L27/306A61L27/50B82Y5/00B82Y30/00B82Y40/00A61L2400/12A61L2400/18A61L2420/02A61L2420/08
Inventor 张兰毛梦婷袁海彦憨勇
Owner XI AN JIAOTONG UNIV
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