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Titanium alloy bone implant adopting bio-coating structure and preparation method of titanium alloy bone implant

A bio-coating, titanium alloy technology, applied in the medical field, can solve the problems of allergic reaction, high toxicity of cobalt, difficult product processing, etc., and achieve the effect of improving adhesion and reducing rejection.

Active Publication Date: 2017-12-29
张阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that cobalt is more toxic to cells. It may also cause allergic reactions after implantation in the human body, and even have carcinogenic effects
Moreover, the price is expensive and the product processing is difficult, so it is rarely used now.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A titanium alloy bone implant with a biological coating structure, comprising a titanium alloy substrate, a porous metal powder coating and a biological coating, the porous metal powder coating is uniformly distributed on the surface of the titanium alloy substrate, and the biological coating is uniformly distributed on the surface of the titanium alloy substrate Porous metal powder-coated surface.

[0037] The material of the porous metal powder coating is Ti powder and Mg powder, and the mass ratio of Ti powder to Mg powder is 7:3.

[0038] The biological coating consists of the following components in parts by weight:

[0039] 200 parts gelatin;

[0040] Chitosan 30 parts;

[0041] Hyaluronic acid 20 parts;

[0042] 30 parts of alginate;

[0043] 2 parts of coupling agent.

[0044] The preparation method of biological coating, comprises the following steps:

[0045] Step 1, respectively configure the methanol suspension of gelatin, the methanol suspension of ch...

Embodiment 2

[0059] A preparation method of a titanium alloy bone implant with a biological coating structure, comprising the following steps:

[0060] Step 1. Ultrasonic cleaning the surface of the titanium alloy substrate with deionized water, absolute ethanol and acetone respectively to remove oil and impurities on the surface, then rinse with absolute ethanol, and blow dry with high-purity nitrogen;

[0061] Step 2: Sand blast the surface of the titanium alloy substrate treated in step 1, and then spray the mixed powder of Ti powder and Mg powder (the mass ratio of Ti powder and Mg powder is 7:3) on the surface under the protection of argon gas. Titanium alloy substrate surface;

[0062] Step 3. Immerse the titanium alloy substrate treated in step 2 in 1mol / l KOH solution for 10 hours, take it out, rinse it with absolute ethanol, dry it with high-purity nitrogen, and then vacuum it at 300°C for 10 hours ;

[0063] Step 4. Rinse the titanium alloy matrix treated in step 3 with absolut...

Embodiment 3

[0067] A preparation method of a titanium alloy bone implant with a biological coating structure, comprising the following steps:

[0068] Step 1. Ultrasonic cleaning the surface of the titanium alloy substrate with deionized water, absolute ethanol and acetone respectively to remove oil and impurities on the surface, then rinse with absolute ethanol, and blow dry with high-purity nitrogen;

[0069] Step 2: Sand blast the surface of the titanium alloy substrate treated in step 1, and then spray the mixed powder of Ti powder and Mg powder (the mass ratio of Ti powder and Mg powder is 7:3) on the surface under the protection of argon gas. Titanium alloy substrate surface;

[0070] Step 3. Immerse the titanium alloy substrate treated in step 2 in 1mol / l KOH solution for 11 hours, take it out, rinse it with absolute ethanol, dry it with high-purity nitrogen, and then vacuum it at 350°C for 10 hours ;

[0071] Step 4. Rinse the titanium alloy matrix treated in step 3 with absolut...

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Abstract

The invention discloses a titanium alloy bone implant adopting a bio-coating structure and a preparation method of the titanium alloy bone implant. The titanium alloy bone implant comprises a titanium alloy matrix, a porous metal powder coating and a bio-coating, wherein the porous metal powder coating is uniformly distributed on the surface of the titanium alloy matrix and the bio-coating is uniformly distributed on the surface of the porous metal powder coating. The porous metal powder coating and the bio-coating are designed on the implant, multiple pores are formed in the surface of the implant by the aid of the porous metal alloy coating, the bio-coating enters the pores during coating to form closer connection between coatings, the frozen bio-coating forms tiny pores, the bio-coating is made of a resistance-free and easy-to-absorb material, thus, adhesion, proliferation and differentiation of cells are facilitated, regenerated cell tissue can be tightly combined with the porous titanium alloy coating after the bio-coating is completely degraded, the adhesion of regenerated tissue and the implant can be improved, and rejection reactions can be reduced.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a titanium alloy bone implant with a biological coating structure. Background technique [0002] The traditional orthopedic bone implant materials currently used clinically mainly include stainless steel series, cobalt-chromium-molybdenum alloys, titanium and titanium alloys, etc., which are permanent implant materials. [0003] (1) Stainless steel series: all are austenitic iron-based alloys. Based on austenitic stainless steel, titanium is added to make the material have high corrosion resistance. Molybdenum is added, and impurities such as sulfur and phosphorus are correspondingly reduced, thereby improving the hardness and corrosion resistance of the material. The main properties of nickel in stainless steel are rust prevention, corrosion resistance, and improving the toughness of the material. 316, 316L, 317, 3l7L grades of stainless steel, good inertness and strong corr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/34A61L27/50A61L27/56A61L27/58
CPCA61L27/06A61L27/306A61L27/34A61L27/50A61L27/56A61L27/58A61L2400/18A61L2420/02A61L2420/06A61L2420/08A61L2430/02C08L89/00C08L5/08C08L5/04
Inventor 张阳
Owner 张阳
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