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Nano hydroxyapatite coating and preparation method thereof and electrostatic atomization device

A nano-hydroxyapatite, electrostatic atomization technology, applied in liquid spraying equipment, coating, medical science and other directions, can solve the problems of lack of general applicability, inability to be mass-produced and popularized, complicated operation, etc. Precise control, good mechanical properties, high biological activity

Inactive Publication Date: 2010-05-12
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, the electrostatic atomization deposition technology (ESD) is mostly used to prepare metal oxide films, and there are some reports on the preparation of depositing silk fibroin / nanometer hydroxyapatite coatings on metal substrates. After searching the prior art, it was found that China Patent Document No. CN101387002A describes a preparation method of electrodeposition of hydroxyapatite / protein hybrid material on a metal substrate, using calcium nitrate, bovine serum albumin (BSA), diammonium hydrogen phosphate, tungsten, silver, platinum, titanium and ammonia water as raw materials. Firstly, the nano-hydroxyapatite / protein hybrid material is prepared through the template action of BSA, and then it is added to n-butanol solution for ultrasonication, and electrodeposition is carried out at a constant voltage; Chinese Patent Document No. CN1916054A records A preparation method of electrostatic spraying of polymer micro-nanoparticles is developed. A certain proportion of polymer is dissolved in a corresponding solvent; Under the action of electrospray, the solution is electrosprayed into micron or nanometer particles; Z.Ahmad reported in the article Deposition of nano-hydroxyapatite particles utilizing direct and transitional electrohydrodynamic processes that the coating technology was prepared by electrostatic atomization technology, and the coating morphology can be achieved. Controlled control, but this method is limited to all equipment as special equipment, not universally applicable, and cannot be promoted in industrial mass production
In general, in order to make the hydroxyapatite coating on the metal substrate dense and uniform without cracks, especially the precise and controllable coating morphology, the existing technology has the disadvantages of complicated operation or high cost

Method used

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  • Nano hydroxyapatite coating and preparation method thereof and electrostatic atomization device

Examples

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Effect test

Embodiment 1

[0052] Preparation of silk fibroin precursor solution: after cleaning, 4 g of silkworm cocoons are put into boiling 0.5wt% Na 2 CO 3 The solution was boiled for 30 minutes, and then washed with deionized water. The whole process was repeated twice, and the refined silk was obtained after drying; the refined silk was placed in a CaCl-containing 2 9.32g CaCl 2 -CH 3 CH 2 OH-H 2 Heat and stir in the O solution until completely dissolved; raise the temperature of the obtained solution to 80°C, adjust the pH of the solution with ammonia water at 9.5 to 10.5, meter and drop diammonium hydrogen phosphate solution, and continuously adjust the pH at 9.5 to 10.5, and keep stirring and heating after the titration is completed. 3h, after the end, it will automatically drop to room temperature and age;

[0053] After aging for 12 hours, the resulting suspension was washed with deionized water until it was neutral, and suction filtered until most of the water was removed. protein prec...

Embodiment 2

[0057] Preparation of silk fibroin precursor solution: after cleaning, 4 g of silkworm cocoons are put into boiling 0.5wt% Na 2 CO 3 The solution was boiled for 30 minutes, and then washed with deionized water. The whole process was repeated twice, and the refined silk was obtained after drying; the refined silk was placed in a CaCl-containing 2 9.32g CaCl 2 -CH 3 CH 2 OH-H 2 Heat and stir in the O solution until completely dissolved; raise the temperature of the obtained solution to 80°C, adjust the pH of the solution with ammonia water at 9.5 to 10.5, meter and drop diammonium hydrogen phosphate solution, and continuously adjust the pH at 9.5 to 10.5, and keep stirring and heating after the titration is completed. 3h, after the end, it will automatically drop to room temperature and age;

[0058] After aging for 12 hours, the resulting suspension was washed with deionized water until it was neutral, and suction filtered until most of the water was removed. protein prec...

Embodiment 3

[0062] Preparation of silk fibroin precursor solution: after cleaning, 4 g of silkworm cocoons are put into boiling 0.5wt% Na 2 CO 3 The solution was boiled for 30 minutes, and then washed with deionized water. The whole process was repeated twice, and the refined silk was obtained after drying; the refined silk was placed in a CaCl-containing 2 9.32g CaCl 2 -CH 3 CH 2 OH-H 2 Heat and stir in the O solution until completely dissolved; raise the temperature of the obtained solution to 80°C, adjust the pH of the solution with ammonia water at 9.5 to 10.5, meter and drop diammonium hydrogen phosphate solution, and continuously adjust the pH at 9.5 to 10.5, and keep stirring and heating after the titration is completed. 3h, after the end, it will automatically drop to room temperature and age;

[0063] After aging for 12 hours, the resulting suspension was washed with deionized water until it was neutral, and suction filtered until most of the water was removed. protein prec...

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Abstract

The invention provides a nano hydroxyapatite coating and a preparation method thereof and an electrostatic atomization device, belonging to the technical field of medical biological coating. The coating has the following components in weight percent: 10-30% of silk fibroin and 70-90% of nano hydroxyapatite. The preparation method is as follows: firstly carrying out degumming process and dissolving process to obtain the silk dissolving liquid; preparing into the suspending liquid of silk fibroin-nano hydroxyapatite composite precipitate; washing to neutrality by deionized water to prepare intoprecursor solution; and adopting the electrostatic atomization sedimentation method to lead the precursor solution to be coated on the substrate in atomizing form to prepare into nano hydroxyapatite composite material biological coating. The invention can prepare the silk fibroin / nano hydroxyapatite coating with compact accumulation and no cracks, and the shape thereof can be controlled.

Description

technical field [0001] The invention relates to a material in the technical field of medical biological coatings and a preparation method thereof, in particular to a silk fibroin-based nano-hydroxyapatite coating, a preparation method thereof, and an electrostatic atomization device. Background technique [0002] The necessary condition for the success of hard tissue repair is that the replacement material should not only be directly combined with the hard tissue, but also have a high compressive strength. Materials commonly used in hard tissue repair include bioactive ceramics and biocompatible metals, but these two materials do not meet the above two conditions at the same time. The main component of bioactive ceramics is phosphate, among which hydroxyapatite (HA) is basically the same as the mineral composition of bone tissue, and has the best biological activity; metals have been widely used due to their excellent mechanical properties, titanium and its Alloys are ideal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/06A61L27/04A61L27/02B05B5/08
Inventor 陈玉云范纯泉叶晓健盛小海李家顺付建伟许国华何丹农何海龙金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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