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Antibacterial hydrogel composite material and preparation method thereof

A composite material and hydrogel technology, applied in local antibacterial agents, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of drug resistance, poor hygroscopicity, and weak antibacterial properties, and achieve difficult aggregation and small particle size , the effect of preventing wound infection

Active Publication Date: 2016-01-27
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of poor hygroscopicity, weak antibacterial property or drug resistance existing in existing wound dressings, the present invention combines the excellent properties of the above three materials to prepare a hydrogel wound dressing with strong antibacterial properties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Chitosan with mass volume percentage of 2.43%, γ-polyglutamic acid of 2.57%, that is, chitosan 0.2434g, γ-PGA 0.2566g, stir and mix in 10mL distilled water, add 1% rapidly while stirring Acetic acid solution, stir rapidly for 15s to mix evenly, stop stirring and let it stand at room temperature to obtain a uniform hydrogel, put the obtained hydrogel material into distilled water, stir gently with a magnetic stirrer, change the distilled water every 6h, until the pH of the system No change; freeze-dry the hydrogel material after acid removal at -20°C for 12 hours until it becomes a sponge;

[0014] The configuration concentration is 2.5μg / mlAgNO 3 Solution 20ml, and 0.164mgPVP was added to it, stirred rapidly until completely dissolved and mixed evenly. Cut 1 / 6 mass of the freeze-dried hydrogel material and soak it in the homogeneous solution for 35 minutes until the swelling is balanced;

[0015] Add the newly prepared NaBH at a concentration of 2.75 μg / ml 4 Solution...

Embodiment 2

[0017] Mass volume percentage is 2.53% chitosan, 2.53% gamma-polyglutamic acid, namely chitosan 0.2533g, gamma-PGA0.2533g, stir and mix in 10mL distilled water, add 0.8% rapidly while stirring Acetic acid solution, stir rapidly for 13s to mix evenly, stop stirring and let it stand at room temperature to obtain a uniform hydrogel, put the obtained hydrogel material into distilled water, stir gently with a magnetic stirrer, change the distilled water every 6h, until the pH of the system No change; freeze-dry the hydrogel material after acid removal at -20°C for 12 hours until it becomes a sponge;

[0018] The configuration concentration is 3.5μg / mlAgNO 3 Solution 20ml, and 0.25mg of PVP was added to it, stirred rapidly until completely dissolved and mixed evenly. Take 1 / 4 of the above-mentioned freeze-dried hydrogel material and soak it in the homogeneous solution for 40 minutes until the swelling is balanced;

[0019] Add the newly prepared NaBH at a concentration of 3.00 μg / ...

Embodiment 3

[0021] Chitosan with a mass volume percentage of 1.01%, γ-polyglutamic acid of 2.02%, that is, chitosan 0.1013g, γ-PGA 0.2026g, stir and mix in 6mL distilled water, and quickly add 1% while stirring Acetic acid solution, stirred rapidly for 10s to mix evenly, after stopping the stirring, let it stand at room temperature to obtain a uniform hydrogel, put the obtained hydrogel material into distilled water, stir gently with a magnetic stirrer, change the distilled water every 6h, until the system pH No change; freeze-dry the hydrogel material after acid removal at -20°C for 12 hours until it becomes a sponge;

[0022] The configuration concentration is 3.5μg / mlAgNO 3 20ml of the solution, and 0.25mg of PVP was added to it, stirred rapidly until it was completely dissolved and mixed uniformly, soaked 1 / 3 of the above-mentioned freeze-dried hydrogel material in the uniform solution for 40min until the swelling was balanced;

[0023] Add the newly prepared NaBH at a concentration ...

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Abstract

The invention provides an antibacterial hydrogel composite material and a preparation method thereof. The antibacterial trauma repair material is hydrogel formed by chitosan and gamma-polyglutamic acid according to a mass ratio of 1 / 0.5-2 through electrostatic interaction, and nano silver is synthesized and loaded in situ on the hydrogel by taking PVP as a dispersant. the preparation method is simple, convenient and quick, and the trauma repair material is high in practicability. The composite hydrogel trauma repair material integrates bactericidal and immune activity, high biocompatibility and hemostatic activity that chitosan has, high water absorbency that gamma-polyglutamic and broad-spectrum antibacterial property and freeness of drug resistance that nano silver has, and composite hydrogel nano silver is small in grain diameter, uniform in distribution and less prone to aggregation, thereby having high antibacterial performance; when the material is used for wound dressing, wound infection can be avoided effectively, and wound healing can be accelerated.

Description

Technical field: [0001] The invention relates to a hydrogel composite material and a preparation method thereof, specifically an antibacterial hydrogel composite material prepared by in-situ synthesis of chitosan, γ-polyglutamic acid and nano silver and a preparation method thereof . Background technique: [0002] An ideal biomedical dressing needs to have good biocompatibility, hemostasis and antibacterial, absorb wound leachate, keep the wound clean, and provide a moist healing environment for wound repair. Hydrogel is a new type of biomaterial, which has important application value in wound repair. Wound infection and the complications caused by wound repair during wound repair are an important problem in current clinical application. In recent years, more antibiotics have been used to solve such problems. However, the widespread use of antibiotics has led to drug resistance of pathogenic bacteria, so it is necessary to find new broad-spectrum antibacterial drugs to rep...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/26A61L15/44A61L15/46A61L15/42A61L27/48A61L27/52A61L27/54A61K8/06A61K8/73A61K8/84A61Q19/00A61P31/02
Inventor 王淑芳潘晓晨王建涛陈蓉蓉宋佳颐李悦源宋存江
Owner NANKAI UNIV
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