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Nanometer bacterial cellulose\polyvinyl alcohol\polyethylene glycol porous composite hydrogel

A composite hydrogel and nanobacteria technology, applied in the field of biological materials, can solve the problems of uneven cellulose fragment homogenization, uneven cellulose dispersion, poor structure controllability, etc., and achieves enhanced mechanical properties, high degree of dispersion, The effect of enhanced controllability

Inactive Publication Date: 2016-01-13
NANJING UNIV OF SCI & TECH
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Problems solved by technology

However, mechanical crushing of bacterial cellulose can only obtain inhomogeneous homogenization of cellulose fragments, and the degree of fineness is not high. It may cause uneven dispersion of cellulose in the PVA polymer network when it is prepared into a mixed solution; Solution cross-linking, there may be residual hazards affecting its biomedical use
[0005] Chinese patent 201210510344.8 discloses a method for preparing bacterial cellulose / polyvinyl alcohol composite materials using bacterial cellulose of wet film block as raw material, removing impurities from natively fermented bacterial cellulose, and impregnating it into a polyvinyl alcohol with a concentration of 20-40%. In the vinyl alcohol aqueous solution, the composite material is prepared by freeze-thaw crosslinking, but the composite material is directly impregnated, and the structural controllability is poor. The small three-dimensional pore size of bacterial cellulose limits its biological application. After impregnation, the network structure is denser, and impregnation In case of uneven coating

Method used

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  • Nanometer bacterial cellulose\polyvinyl alcohol\polyethylene glycol porous composite hydrogel
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preparation example Construction

[0031] to combine figure 1 , the preparation method of nano bacterial cellulose\polyvinyl alcohol\polyethylene glycol porous composite hydrogel, the specific steps are as follows:

[0032] The first step: get the bacterial cellulose film (thickness of film 1mm~1cm) of Acetobacter xylinum dynamic fermentation, use the NaOH of mass fraction 0.1%~4% and 0.1%~4%H 2 o 2 Treat at 60-90°C for 1-5 hours, and then wash it with deionized water to obtain a pure bacterial cellulose raw material with a three-dimensional network structure;

[0033] Step 2: Cut the cleaned bacterial cellulose wet film into small pieces of 1-1.5cm×1-1.5cm, squeeze out the water as much as possible and place it at a concentration of 0.01-0.1g / mL at a concentration of 50%-65%. In sulfuric acid solution, react at 45-55°C for 48 hours, collect the solution, centrifuge and wash at 8000-1000rpm, and then dialyze to pH=7;

[0034] Step 3: Prepare a PVA aqueous solution with a mass concentration of 8% to 10%, diss...

Embodiment 1

[0039]The bacterial cellulose film obtained by the static fermentation of Acetobacter xylinum was treated with 0.2% NaOH and 0.2% H 2 o 2 Treat it in a water bath at 80°C for 2 hours, take out the deionized water and rinse it; squeeze out the water as much as possible, cut it into regular 1cm×1cm small pieces with scissors, put it in 50% sulfuric acid solution at 0.01g / mL, and keep at 45°C The reaction was stirred for 48 hours, and the collected solution was centrifuged and dialyzed until completely neutral. Prepare a PVA aqueous solution with a mass concentration of 8%, prepare 4mL of a mixed solution according to the mass ratio of BC / PVA of 1 / 1, stir at 60°C for 2h, ultrasonicate for 0.5h, then add 0.3mL of a 3% PEG solution dropwise, and stir at 60°C 2h, ultrasonic 0.5h. Then, the uniformly mixed solution was added dropwise to the prepared glass microsphere template, the liquid level was about 3mm, frozen at -20°C for 6h, and then placed at room temperature for 6h, and so...

Embodiment 2

[0043] The bacterial cellulose film obtained by the static fermentation of Acetobacter xylinum was treated with 0.2% NaOH and 0.2% H 2 o 2 Treat it in a water bath at 80°C for 2 hours, take out the deionized water and rinse it; squeeze out the water as much as possible, cut it into regular 1cm×1cm small pieces with scissors, put it in 50% sulfuric acid solution at 0.05g / mL, and keep it at 50°C The reaction was stirred for 48 hours, and the collected solution was centrifuged and dialyzed until completely neutral. Prepare 8% PVA aqueous solution, prepare 4mL mixed solution according to BC / PVA mass ratio 1 / 2, stir at 70°C for 3h, ultrasonicate for 0.5h, then add 0.3mL of 5% PEG solution dropwise, stir at 70°C for 3h, Ultrasonic 0.5h. Then, the uniformly mixed solution was added dropwise to the prepared glass microsphere template, the liquid level was about 3mm, frozen at -20°C for 7h, and then placed at room temperature for 6h, and repeated 3 times. Finally, it was slightly dr...

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Abstract

The invention discloses a nanometer bacterial cellulose\polyvinyl alcohol\polyethylene glycol porous composite hydrogel. The porous composite hydrogel comprises nanometer bacterial cellulose, polyvinyl alcohol and polyethylene glycol. The invention also discloses a preparation method of the porous composite hydrogel. The method comprises the following steps: hydrolyzing clean bacterial cellulose by sulfuric acid to obtain a nanometer cellulose solution, carrying out neutral treatment, mixing the treated solution in a polyvinyl alcohol solution, carrying out ultrasonic dispersion until uniformity, adding a small amount of a polyethylene glycol solution, carrying out ultrasonic stirring mixing, adding the above obtained mixed solution into a glass bead template in a dropwise manner, repeatedly freeze-thawing to cross-link the obtained mixture, and drying to obtain the porous composite hydrogel. The porous composite hydrogel prepared in the invention has the advantages of low cost, mild reaction, fast speed, good biocompatibility, high mechanical strength, uniform porous structure, and wide application prospect in the fields of biomedical science and tissue engineering.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a nano-bacterial cellulose / polyvinyl alcohol / polyethylene glycol porous composite hydrogel and a preparation method thereof. Background technique [0002] Polymer hydrogel has high water content, strong hydrophilicity, strong plasticity and excellent biocompatibility, and has similar properties to human tissue. In recent years, it has been widely used as a biomedical material such as wound dressings and organ repair. And drug sustained release and other fields. Among them, polyvinyl alcohol (PVA) hydrogel is widely used in the biomedical field due to its stable chemical properties, excellent permeability to water molecules and good flexibility. Polyethylene glycol (PEG), as a commonly used drug wrapping material, has a wide range of compatibility, moisture retention and dispersibility. Bacterial Cellulose (BC) can be used as a reinforcing fiber in water...

Claims

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Application Information

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IPC IPC(8): C08L29/04C08L1/02C08L71/02C08J9/00
Inventor 孙东平陈啸杨加志陈春涛张衡黄洋朱春林
Owner NANJING UNIV OF SCI & TECH
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