Hydroxybutyl chitosan/oxidized sodium alginate/nano-silver composite hydrogel dressing plaster

A technology for oxidizing sodium alginate and hydroxybutyl chitosan, which is used in medical science, bandages, absorbent pads, etc., can solve the problems of mutual adhesion of wounds, unfavorable natural recovery of wounds, and unbearable pain for users, and achieves safety. Improve and prevent bacteria from invading wounds and have strong bactericidal and bacteriostatic effects

Active Publication Date: 2015-12-02
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these wound dressings tend to stick to the wound when they are replaced, so when the dressing is torn off, new epithelial cells or wounds that have gradually healed may be torn together, causing the user to suffer unbearably, and quite painful. Not conducive to the natural recovery of the wound

Method used

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  • Hydroxybutyl chitosan/oxidized sodium alginate/nano-silver composite hydrogel dressing plaster
  • Hydroxybutyl chitosan/oxidized sodium alginate/nano-silver composite hydrogel dressing plaster

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: a kind of hydroxybutyl chitosan / oxidized sodium alginate / nano-silver composite hydrogel dressing, the steps of its preparation method are as follows:

[0037] 1. Set the specification to 60g / m 2 The medical non-woven fabric (3cm×3cm) is completely soaked in 10ml of 25wt% oxidized sodium alginate aqueous solution, loaded with cross-linking agent, soaked for 10min, then taken out and placed in a petri dish, and the unloaded oxidized sodium alginate aqueous solution was transferred to In the petri dish, all drop on the medical non-woven fabric;

[0038] 2. Add 2ml of 50μg / ml nano-silver colloid solution dropwise to 10ml of 16wt% hydroxybutyl chitosan aqueous solution and stir evenly to obtain mixed solution A;

[0039] 3. Evenly spread the mixed solution A on the medical non-woven fabric treated in step 1, and let it stand for 5-10 minutes. The cross-linking of the hydrogel is completed and combined with the medical non-woven fabric layer to form a whole. T...

Embodiment 2

[0040] Embodiment 2: a kind of hydroxybutyl chitosan / oxidized sodium alginate / nano-silver composite hydrogel dressing, the steps of its preparation method are as follows:

[0041] 1. Set the specification to 60g / m 2 A medical non-woven fabric (3cm×3cm) was completely soaked in 10ml of 18wt% oxidized sodium alginate aqueous solution, loaded with a crosslinking agent, soaked for 10min, then taken out and placed in a petri dish, and the unloaded oxidized sodium alginate aqueous solution was transferred to In the petri dish, all drop on the medical non-woven fabric;

[0042] 2. In 10ml of 24wt% hydroxybutyl chitosan aqueous solution, drop 4ml of 50μg / ml nano-silver colloidal solution and stir evenly to obtain mixed solution A;

[0043] 3. Evenly spread the mixed solution A on the medical non-woven fabric treated in step 1, and let it stand for 5-10 minutes. The cross-linking of the hydrogel is completed and combined with the medical non-woven fabric layer to form a whole. This w...

Embodiment 3

[0044] Embodiment 3: a kind of hydroxybutyl chitosan / oxidized sodium alginate / nano-silver composite hydrogel dressing, the steps of its preparation method are as follows:

[0045] 1. Set the specification to 60g / m 2 The medical non-woven fabric (3cm×3cm) is completely soaked in 10ml of 25wt% oxidized sodium alginate aqueous solution, loaded with cross-linking agent, soaked for 10min, then taken out and placed in a petri dish, and the unloaded oxidized sodium alginate aqueous solution was transferred to In the petri dish, all drop on the medical non-woven fabric;

[0046] 2. Add 8ml 50μg / ml nano-silver colloid solution dropwise to 10ml 30wt% hydroxybutyl chitosan aqueous solution and stir evenly to obtain mixed solution A;

[0047] 3. Evenly spread the mixed solution A on the medical non-woven fabric treated in step 1, and let it stand for 5-10 minutes. The cross-linking of the hydrogel is completed and combined with the medical non-woven fabric layer to form a whole. This wh...

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Abstract

The invention belongs to the technical field of medical material production and particularly discloses a hydroxybutyl chitosan / oxidized sodium alginate / nano-silver composite hydrogel dressing plaster. The steps of manufacturing the hydroxybutyl chitosan / oxidized sodium alginate / nano-silver composite hydrogel dressing plaster are that a medical non-woven fabric is soaked in oxidized sodium alginate (OSA) aqueous solution (a crosslinking agent) and then taken out; nano-silver (n-Ag) colloidal solution is added dropwise to hydroxybutyl chitosan (HBCS) aqueous solution and mixed, the well treated non-woven fabric is evenly coated with the mixed solution, hydrogel is formed by crosslinking at normal temperature and then transferred to a PU film medical adhesive tape with pressure-sensitive adhesive, the hydrogel is covered with release paper, the HBCS / OSA / n-Ag composite hydrogel dressing plaster is obtained, and gamma ray sterilization is performed after sealing. According to the technical scheme, the hydroxybutyl chitosan / oxidized sodium alginate / nano-silver composite hydrogel dressing plaster has the advantages of being low in cost and simple in process; in view of the facts that HBCS has good biocompatibility, OSA is non-toxic to the human body and n-Ag has good antimicrobial performance, the prepared hydrogel can be applied to wound dressings and hemostatic materials and the like. The hydroxybutyl chitosan / oxidized sodium alginate / nano-silver composite hydrogel dressing plaster has the advantages of having hygroscopicity and being remarkable in antibacterial performance and low in cytotoxicity.

Description

technical field [0001] The invention relates to the technical field of medical material production, in particular to a wound repairing hydrogel dressing suitable for burn and scald wound care. The dressing can be used as a wound dressing, can promote tissue healing, has remarkable antibacterial performance, low cytotoxicity, and has Good biocompatibility. Background technique [0002] Traditional wound dressings are made of natural plant fibers or animal hairs, such as gauze, cotton pads, wool, and various types of oiled gauze. This type of dressing is only a temporary covering material and needs to be replaced within a certain period of time. However, when these wound dressings are replaced, they tend to stick to the wound. Therefore, when the dressing is torn off, the new epithelial cells or the wound that has gradually healed may be torn together, causing the user to suffer unbearably, and quite painful. Not conducive to the natural recovery of the wound. [0003] Comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44
Inventor 张爱清胡庆刘书正陈小随秦四勇
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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