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Artificial articular cartilage material and preparation method thereof

A technology for artificial joints and cartilage, which is applied in the field of chemical modification of hydrogel soft materials, can solve problems such as poor biological activity, mechanical properties that cannot meet the requirements of high stress on articular cartilage, and inability to integrate surrounding tissues, etc., to achieve clear scientific significance, Effects of improving mechanical properties and biological activity and expanding the scope of application

Inactive Publication Date: 2014-06-11
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under such a high stress, the mechanical properties of this soft material as an artificial articular cartilage replacement material cannot meet the high stress requirements for articular cartilage in normal human sports activities.
Secondly, this soft material is used as artificial muscle and other artificial soft tissue replacement materials. Although it has strong biocompatibility, it cannot be integrated with surrounding tissues due to its poor bioactivity.

Method used

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  • Artificial articular cartilage material and preparation method thereof
  • Artificial articular cartilage material and preparation method thereof
  • Artificial articular cartilage material and preparation method thereof

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preparation example Construction

[0017] A kind of preparation method of artificial articular cartilage material of the present invention, comprises the following steps:

[0018] Prepare an aqueous solution of graphene oxide nanosheets,

[0019] uniformly dispersing needle-shaped nano-hydroxyapatite particles with a particle size of 10-1000nm in an aqueous solution of graphene oxide nanosheets to obtain a stable mixed aqueous solution of hydroxyapatite and graphene oxide;

[0020] In an oxygen-free environment, add the raw materials for free radical polymerization to synthesize polyacrylamide and sodium alginate hydrogel in the above mixed aqueous solution in sequence, and after 20-90min, undergo free radical polymerization at a temperature of 30-70°C. Thus, polyacrylamide-sodium alginate-graphene oxide-hydroxyapatite composite hydrogel was obtained.

[0021] The anaerobic protective gas used in the anaerobic protective environment is subject to no reaction with the colloidal solution, and commonly used prote...

Embodiment 1

[0024] 1) The aqueous solution of graphene oxide GO nanosheets prepared by the Hummers method was fully ultrasonicated for 1 hour.

[0025] 2) Mechanically blend 5% HA in the 15ml GO nanosheet aqueous solution with a concentration of 2mg / ml above, and ultrasonically oscillate for 30min to ensure that HA is uniformly dispersed in the GO nanosheet aqueous solution.

[0026] 3) In the above mixed solution of GO and HA, under the protective environment of high-purity nitrogen, the raw materials for the synthesis of PAM-ALG hydrogel by free radical polymerization, namely, monomer 1: 5 g of acrylamide; initiator: over Ammonium sulfate 0.015g; covalent bond crosslinking agent: methylenebisacrylamide 0.0031g; catalyst: N,N,N',N',-tetramethyldiacetamide 16μL; ionic bond crosslinking agent: anhydrous chlorine Calcium 0.0661g; monomer 2: sodium alginate 0.5g; dehydrating agent: carbodiimide 0.04g and N-hydroxysuccinimide 0.02g. After 60 min, the PAM-ALG-GO-HA composite hydrogel was prep...

Embodiment 2

[0031] 1) The aqueous solution of graphene oxide GO nanosheets prepared by Brodie method was fully ultrasonicated for 1.5 hours.

[0032] 2) Mechanically blend 3% HA in the 20ml GO nanosheet aqueous solution with a concentration of 0.5mg / ml above, and ultrasonically oscillate for 40min to ensure that HA is uniformly dispersed in the GO nanosheet aqueous solution.

[0033] 3) In the above mixed solution of GO and HA, in the protective environment of high-purity argon, the raw materials for the synthesis of PAM-ALG hydrogel by free radical polymerization, namely, monomer 1: acrylamide; initiator: over Ammonium sulfate 0.015g; covalent bond crosslinking agent: methylenebisacrylamide 0.0031g; catalyst: N,N,N',N',-tetramethyldiacetamide 16μL; ionic bond crosslinking agent: anhydrous chlorine Calcium 0.0661g; monomer 2: sodium alginate 0.6g; dehydrating agent: carbodiimide 0.04g and N-hydroxysuccinimide 0.02g. After 40 min, the PAM-ALG-GO-HA composite hydrogel was prepared by free ...

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Abstract

The invention discloses an artificial articular cartilage material, which relates to the field of chemical modification of hydrogel soft materials. Polyacrylamide-sodium alginate hydrogel is modified with graphene oxide and hydroxyapatite, and PAM-ALG-GO-HA composite hydrogel is prepared by a free radical polymerization reaction. The preparation method comprises the following steps: gradually adding needle-like nano HA particles into a GO solution which is uniformly dispersed in advance to form a mixed aqueous solution, adding an acrylamide monomer, an ALG monomer and related reactants for synthesizing PAM-ALG hydrogel, and performing the free radical polymerization reaction to prepare the PAM-ALG-GO-HA composite hydrogel. According to the artificial articular cartilage material disclosed by the invention, chemical modification is performed on the PAM-ALG hydrogel by fully using the two-dimensional structure of a GO nano chip and the functional groups on the surface and the excellent biological activity of HA, the mechanical property and biological activity of the PAM-ALG hydrogel are effectively improved, the application range of the PAM-ALG hydrogel is expanded, and the artificial articular cartilage material has clear scientific significance and a huge application value.

Description

technical field [0001] The invention relates to a chemical modification method of a hydrogel soft material, in particular to a preparation method of a novel artificial articular cartilage material PAM-ALG-GO-HA. Background technique [0002] With the intersecting development of bionics and new materials, the research on new materials with excellent performance prepared by bionic human body structure has been paid more and more attention. A layer of 2-7mm thick smooth and elastic tissue-articular cartilage covering the surface of the human knee joint can withstand various high-load pressures and impacts in a person's life cycle, and the natural life span can be as high as 70-80 years. And it can make the joints move freely, and at the same time, it can absorb the energy generated by the vibration during human activities, and play the role of cushioning and protecting the joints. At present, the "gold standard" of artificial knee replacement materials is cobalt-based alloy an...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/16A61L27/12A61L27/08A61L27/52C08F251/00C08F220/56C08B37/04
Inventor 魏强吝德智张善勇
Owner TIANJIN UNIV
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