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Polyethylene artificial joint capable of improving biocompatibility and tribological property and preparation method thereof

A technology of biocompatibility and artificial joints, which is applied in the field of polyethylene artificial joints and its preparation, can solve the problems of polyethylene degradation and accelerated aging, and achieve the goal of reducing aseptic loosening, reducing tissue reactions and improving biocompatibility Effect

Inactive Publication Date: 2011-06-01
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while these methods improve the wear resistance, they are at the expense of the performance of UHMWPE itself. For example, ray irradiation will cause polyethylene to degrade and accelerate its aging; carbon fibers and nanoparticles filled in polyethylene are harmful to the human body. Biocompatibility and medical clinical aspects have not yet been evaluated

Method used

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  • Polyethylene artificial joint capable of improving biocompatibility and tribological property and preparation method thereof
  • Polyethylene artificial joint capable of improving biocompatibility and tribological property and preparation method thereof
  • Polyethylene artificial joint capable of improving biocompatibility and tribological property and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Put a polyethylene sample with a molecular weight of 2 million into methanol and ultrasonically clean it for 30 minutes, wash it twice, and dry it; then soak it in an acetone solution with a concentration of 0.02g / ml benzophenone, take it out after 2 hours, The photosensitizer-precoated polyethylene was prepared by vacuum drying in the dark for 1 hour at room temperature to remove the solvent.

[0018] Immerse the polyethylene sample above in 0.5mol / L aqueous solution of 2-methylpropanoyloxyethylphosphorylcholine, blow in nitrogen gas and keep stirring, heat to 60°C, then keep the temperature constant, and irradiate with 500W ultraviolet light Irradiate for 15 minutes, wash with ethanol and deionized water at 50°C, and dry under vacuum for 24 hours.

Embodiment 2

[0020] Put a polyethylene sample with a molecular weight of 3 million into methanol and ultrasonically clean it for 30 minutes, wash it twice, and dry it; then soak it in an acetone solution with a concentration of 0.04g / ml benzophenone, take it out after 2 hours, The photosensitizer-precoated polyethylene was prepared by vacuum drying in the dark for 1 hour at room temperature to remove the solvent.

[0021] Immerse the polyethylene sample above in 0.5mol / L aqueous solution of 2-methylpropanoyloxyethylphosphorylcholine, blow in nitrogen gas and keep stirring, heat to 40°C and keep the temperature, and irradiate with 500W ultraviolet light Leave on for 20 minutes, wash with 50°C ethanol and deionized water, and dry under vacuum for 24 hours.

Embodiment 3

[0023] Put a polyethylene sample with a molecular weight of 5 million into methanol and ultrasonically clean it for 30 minutes, wash it twice, and dry it; then soak it in an acetone solution with a concentration of 0.02g / ml benzophenone, take it out after 2 hours, The photosensitizer-precoated polyethylene was prepared by vacuum drying in the dark for 1 hour at room temperature to remove the solvent.

[0024] Immerse the polyethylene sample above in 0.5mol / L aqueous solution of 2-methylpropyloxyethylphosphorylcholine, blow in nitrogen gas and keep stirring, heat to 30°C and keep the temperature, and irradiate with 500W ultraviolet light Leave on for 30 minutes, wash with ethanol and deionized water at 50°C, and dry under vacuum for 24 hours.

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PUM

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Abstract

The invention discloses a polyethylene artificial joint capable of improving biocompatibility and tribological property and a preparation method thereof. The polyethylene artificial joint comprises a joint head and a superhigh molecular weight polyethylene cotyle, wherein a bionic polymer brush layer is grafted on the surface of the superhigh molecular weight polyethylene cotyle rubbed with the joint head; and the bionic polymer brush layer is a brush-shaped structure formed by connecting a super-lubricant and hydrophilic polymer chain on the surface of polyethylene. The high-biocompatibility polymer brush layer is grafted on the surface of the artificial joint polyethylene by simulating a brush-shaped structure and a lubricating antifriction function of a natural joint cartilage epilimmion synovial cavity, so that the biocompatibility and the tribological property of the artificial joint are obviously improved, and tissue reaction and aseptic loosening are relieved; and the polymer brush molecular chain is chemically bonded on the surface of the superhigh molecular weight polyethylene firmly by an ultraviolet grafting technique. The artificial joint prepared by the method has high wettability and biocompatibility on the friction surface and low friction coefficient, and can relive aseptic loosening and prolong service life.

Description

technical field [0001] The invention belongs to the field of implant medical devices, in particular to a polyethylene artificial joint with improved biocompatibility and tribological performance and a preparation method thereof. Background technique [0002] The artificial joint formed by the combination of ultra-high molecular weight polyethylene socket and metal joint head has the advantage of low cost, and is still widely used in clinical practice. In daily activities, artificial joints are prone to wear under frequent friction, especially the soft material side. Clinical experiments have found that the accumulation of ultra-high molecular weight polyethylene wear debris in the body can induce a series of adverse biological reactions in the basal cells, leading to osteolysis and aseptic loosening around the prosthesis, which seriously affects the quality and service life of the artificial joint. Therefore, it is of great significance to study new artificial joints with w...

Claims

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Application Information

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IPC IPC(8): A61F2/30
CPCA61F2/30767A61F2002/30001
Inventor 熊党生
Owner NANJING UNIV OF SCI & TECH
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