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Layered bionic joint cartilage restoring and replacing material and preparation method thereof

A bionic joint and cartilage repair technology, applied in the field of biomedical composite materials, can solve the problems of difficult improvement of mechanical properties of composite materials, insignificant improvement of mechanical properties of fixed performance composite materials, and decline of biotribological properties, achieving good biological activity and Inducibility, excellent biotribological properties, and the effect of improving mechanical properties

Inactive Publication Date: 2009-11-25
ANHUI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, this cartilage repair material still has the following defects: First, in order to improve the fixation performance between the cartilage repair material and the natural cartilage interface, it is usually necessary to increase the content of bioactive nano-HA in the composite material.
Due to the high content of nano-HA, the water content in the composite material will drop sharply, which will cause the material to lose the lubricating properties of cartilage, and finally reduce its biotribological properties; secondly, as we all know, nanoparticles have high surface energy and activation energy, When the content of nano-HA particles in the composite material is too high, the nanoparticles in the composite material are easy to agglomerate, and at this time, the mechanical properties of the composite material are not only difficult to improve but decline
Finally, when the content of HA particles in the composite material is too low, the fixation performance of the interface between the implant and the natural cartilage and the mechanical properties of the composite material are not significantly improved
Therefore, how to achieve good unity among the biomechanical properties, biotribological properties and connection properties with natural cartilage of implant materials has not been well resolved at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, the present embodiment carries out as follows:

[0023] 1. In a constant temperature water bath at 90°C, while stirring, dissolve 100g of polyvinyl alcohol and 34.91g of calcium hydroxide with a mass percentage concentration of 95% in 250ml of distilled water to prepare a mixed solution of calcium hydroxide and polyvinyl alcohol.

[0024] 2. Dissolve 31.01 g of phosphoric acid with a mass percent concentration of 85% in 105 ml of distilled water to prepare a phosphoric acid solution, and add the phosphoric acid solution dropwise to the mixed solution of calcium hydroxide and polyvinyl alcohol prepared in step 1 through a burette; During the process of dropping the phosphoric acid solution, keep stirring, the temperature is controlled at 90°C, and at the same time, the reaction pH of the solution is controlled by sodium hydroxide to be 10-11;

[0025] 3. After the phosphoric acid solution is added dropwise, continue to stir at 90°C for 12 hours;

[0026] 4...

Embodiment 2

[0031] Embodiment 2, the present embodiment is carried out according to the following steps:

[0032] 1. While stirring, dissolve 125g of polyvinyl alcohol and 34.91g of calcium hydroxide with a mass percentage concentration of 95% in 250ml of distilled water. The temperature of the distilled water is controlled at 85°C to 90°C to prepare calcium hydroxide and polyvinyl alcohol mixture.

[0033] 2. Dissolve 31.01 g of phosphoric acid with a mass percent concentration of 85% in 80 ml of distilled water to prepare a phosphoric acid solution, and add the phosphoric acid solution dropwise to the mixed solution of calcium hydroxide and polyvinyl alcohol prepared in the first step through a burette. During the process of dropping the phosphoric acid solution, keep the mixed solution of calcium hydroxide and polyvinyl alcohol fully stirred, the temperature is controlled at 85°C, and at the same time, the reaction pH of the solution is controlled by sodium hydroxide to be 10-11;

[0...

Embodiment 3

[0040] Embodiment 3, the present embodiment is carried out according to the following steps:

[0041] 1. While stirring, dissolve 34.91 g of 125 g of polyvinyl alcohol and 95% calcium hydroxide in 250 ml of distilled water, and control the temperature of the distilled water at 85° C. to prepare a mixed solution of calcium hydroxide and polyvinyl alcohol.

[0042] 2. Dissolve 31.01 g of phosphoric acid with a mass percent concentration of 85% in 80 ml of distilled water to prepare a phosphoric acid solution, and add the phosphoric acid solution dropwise to the mixed solution of calcium hydroxide and polyvinyl alcohol prepared in the first step through a burette. In the process of dropping the phosphoric acid solution, keep the mixed solution of calcium hydroxide and polyvinyl alcohol under strong stirring, control the temperature at 85°C, and control the reaction pH of the solution to 10-11 by sodium hydroxide;

[0043] 3. After the phosphoric acid solution is added dropwise, c...

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Abstract

Disclosed is a layered bionic joint cartilage restoring and replacing material and the preparation method thereof. The material is a composite material of nanometer hydroxyl apatite with layered structure and polyvinyl alcohol; the layered structure means that the nanometer hydroxyl apatite content in different layer is different, and reduces in order from the bottom layer to the surface lafyer. The invention causes the nanometer hydroxyl apatite with biological activity to distribute in composite material by gradient along the thickness direction; realizes the optimization of the biological mechanical properties and the biology tribological properties of the joint cartilage restoring material, while, can effectively improve the connection strength of the implantation material and the bottom layer natural joint cartilage; and really solves the contradiction between the biological mechanical properties and the biology tribological properties of the artificial joint cartilage restoring material, and the fixing and combination strength of the implantation material and the natural body.

Description

technical field [0001] The invention relates to the technical field of biomedical composite materials, in particular, it is used as an artificial implant material for repairing articular cartilage damage or defect. Specifically, it refers to a preparation method of a layered nano-hydroxyapatite / polyvinyl alcohol gel articular cartilage repair material. Background technique [0002] Polyvinyl alcohol (PVA) hydrogel has high elasticity, stable chemical properties, easy molding, no toxic side effects, good biocompatibility with human tissue, and a three-dimensional network structure and water content similar to natural articular cartilage. At the same time, its biomechanical properties and biotribological properties are similar to those of natural articular cartilage, and it is a potential excellent articular cartilage repair material. [0003] Scholars at home and abroad have studied PVA hydrogel as an artificial articular cartilage repair material. However, there are still ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/12A61L27/16
Inventor 潘育松
Owner ANHUI UNIV OF SCI & TECH
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