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Process for preparing multilayer heterogeneous bionic joint cartilage material

A bionic joint and preparation process technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of aseptic loosening and artificial joint wear, and achieve the effects of sufficient biological activity, not easy to wear and loosen, and good interface lubricity.

Active Publication Date: 2017-09-05
CHINA UNIV OF MINING & TECH
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  • Claims
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AI Technical Summary

Problems solved by technology

[0007] Purpose of the invention: In order to overcome the deficiencies in the prior art, the present invention provides a preparation process for a multi-layered heterogeneous biomimetic articular cartilage material, through which a biomimetic articular cartilage material similar in structure and function to natural articular cartilage is obtained, Solve the problem of wear and aseptic loosening of artificial joints

Method used

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  • Process for preparing multilayer heterogeneous bionic joint cartilage material
  • Process for preparing multilayer heterogeneous bionic joint cartilage material
  • Process for preparing multilayer heterogeneous bionic joint cartilage material

Examples

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Embodiment 1

[0033] Such as figure 1 As shown, a multilayer heterogeneous biomimetic articular cartilage material preparation process includes the following steps:

[0034] 1) Soak the polyethylene block (molecular weight: 3 million) in the dichromic acid oxidation solution, place it in a 75°C water bath for 10 minutes, and then place it in a 50°C nitric acid solution for 10 minutes to remove the small molecules formed on the surface after oxidation Material, take out and clean with a large amount of deionized water; Described dichromic acid oxidation solution is to be configured by mass percentage 1:4 by potassium dichromate and concentrated sulfuric acid;

[0035] 2) Weigh 25% of polyvinyl alcohol, 3% of nano-hydroxyapatite and 72% of deionized water in a container, swell at room temperature for 24 hours, and then place the container in a constant temperature water bath at 95°C to prepare Get out the PVA / HA mixed solution; take 7% polyvinyl alcohol, 1.5% concentrated sulfuric acid and 9...

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Abstract

The invention discloses a process for preparing a multilayer heterogeneous bionic joint cartilage material. The preparation process comprises the following steps: taking polyethylene subjected to surface activation treatment as a matrix, and cross-linking a polyvinyl alcohol / hydroxyapatite (PVA / HA) composite hydrogel layer with inner pores perpendicular to the matrix on the surface of the matrix by adopting in-situ chemical grafting and orientated solidification; jointing a polyvinyl alcohol / hydroxyapatite / silk (PVA / HA / Silk) composite hydrogel layer with inner pores embedded with one another by utilizing a non-orientated solidification method; and finally, constructing a polyvinyl alcohol / hydroxyapatite / polyacrylic acid (PVA / HA / PAA) composite hydrogel dense film with inner pores parallel to the matrix on the surface of the matrix, thereby obtaining the multilayer heterogeneous bionic joint cartilage material with high strength, low permeability and wear resistance. The prepared bionic cartilage material has the structure and function similar to those of natural cartilage, is difficult to wear and loosen, excellent in interfacial lubricating property and sufficient in biological activity, and achieves the effect of replacing the cartilage to a certain degree.

Description

technical field [0001] The invention belongs to the technical field of cartilage material preparation, and in particular relates to a preparation process of a bionic articular cartilage material, in particular to a preparation process of a multilayer heterogeneous bionic articular cartilage material. Background technique [0002] The joint surface of the human body is covered with articular cartilage. In the physiological environment of the human body, articular cartilage can carry and transmit 7-9 times the weight of the human body, and can provide excellent load-bearing and lubricated articular surfaces. Its friction coefficient is extremely low, about 0.001-0.03. Since the joint is the biological friction pair with the largest load on the human body, the articular cartilage has to bear the repeated friction caused by the movement throughout life, so the articular cartilage will continue to wear and degenerate, eventually leading to the occurrence of osteoarthritis. At pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/40A61L27/56A61L27/50A61L27/16A61L27/12A61L27/36
CPCA61L27/12A61L27/16A61L27/3604A61L27/50A61L27/52A61L27/56A61L2430/06A61L2430/24C08L23/06C08L29/04C08L33/02
Inventor 陈凯张德坤杨雪晖许林敏凌意瀚王庆良葛世荣
Owner CHINA UNIV OF MINING & TECH
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