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IIAb18G/CD147 function epitope amino acid sequence of series monoanti-body function and its use

A technology of CD147 and function table, applied in the field of biotechnology and biomedicine, can solve problems such as disappointment

Inactive Publication Date: 2006-03-22
陈志南
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the results of clinical trials on the application of enzyme inhibitors against mesenchymal degradation have been as disappointing as the above-mentioned anti-metastatic treatments.

Method used

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  • IIAb18G/CD147 function epitope amino acid sequence of series monoanti-body function and its use
  • IIAb18G/CD147 function epitope amino acid sequence of series monoanti-body function and its use
  • IIAb18G/CD147 function epitope amino acid sequence of series monoanti-body function and its use

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0011] 1. HAb18G / CD147 functional area 21 AAGTVFTTVEDLG 33 and 39 LTCSLNDSATEV 50 determination of

[0012] (1) Antibody preparation and function

[0013] Ba1b / c mice were immunized with the extracellular region of HAb18G / CD147, and monoclonal antibodies 1B3, 3B3, 5A12, and 6H8 were obtained through hybridoma technology. These five monoclonal antibodies can bind to HCC. Gelatin zymography experiment (see attached figure 1 ) showed that these five monoclonal antibodies all had the effect of inhibiting tumor cells from stimulating their surrounding stromal cells to secrete MMPs. Invasion test (see attached figure 2 ) showed that these antibodies could inhibit the invasion ability of tumor cells.

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Abstract

The present invention provides HAb18G / CD147 function epitone amino acid sequence as shown in the <400>1 or the <400>2 sequence in the sequence list and with serial monoantibody function and the application of the said functional epitone area in preparing medicine for treating tumor recurrence, tumor metastasis, rheumatoid arthritis and osteoarthritis. The found HAb18G / CD147 function area may be used as the targeting molecule in designing, screening and synthesizing its antagonist to block the function of effect cell in inducing and secreting matrix metal protainase, to reduce the degradation of tumor tissue interstitium, joint cartilage erosion and nascent vascularization and to treat tumor recurrence, tumor metastasis, rheumatoid arthritis and osteoarthritis. Therefore, the discovery of the functional epitone has application foreground in developing new medicines.

Description

technical field [0001] The invention relates to the fields of biotechnology and biomedicine, and mainly relates to the application of the HAb18G / CD147 functional epitope region in clinical and pharmaceutical fields. Background technique [0002] At present, 10 million new cancer patients are added every year in the world, and the incidence of cancer is on the rise. According to the World Health Organization, about 6 million cancer patients die every year in the world. Among the major disease mortality and causes of death in my country in 1995, malignant tumors ranked second, accounting for 21.85% of the total number of deaths. Among them, tumors with higher incidence rates include gastric cancer (accounting for 21.76% of the total cancer mortality), liver cancer (17.83%), lung cancer (15.19%), and esophageal cancer (15.02%). For a long time, due to the malignant characteristics of high recurrence and high metastasis of tumors, it has been an urgent problem to be solved in t...

Claims

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Application Information

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IPC IPC(8): C07K4/12A61P35/00
Inventor 陈志南库晓明汪莉李郁杨向民杨滨
Owner 陈志南
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