Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation

A technology of articular cartilage and culture method, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as difficulty in early regeneration

Inactive Publication Date: 2005-08-10
株式会社MMT 吉川秀树 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] However, with the above-mentioned artificial bone auxiliary materials, it takes 24 weeks to completely regenerate even a few millimeters, and it is difficult to say that it is an early regeneration.

Method used

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  • Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation
  • Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation
  • Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0199] 100 mg of PLA-DX-PEG (PLA: DX: PEG=45: 17: 38 (mole ratio)) and 20 μg of rhBMP-2 were mixed and diluted with acetone to prepare a gel-like mixture.

[0200] Use this gel-like mixture to infiltrate the hydroxyapatite porous body (diameter 4mm, length 4mm, porosity 75%, average pore diameter 200 μm, the volume of pores above 5 μm measured by mercury porosimeter accounted for 97% or more), after a certain period of time, the acetone is volatilized, and a uniform mixed layer of bioabsorbable materials and bone formation induction factors is formed on the inner surface of the pores of the hydroxyapatite porous body, and the articular cartilage regeneration is obtained. Material.

[0201] The obtained material for regeneration of articular cartilage was embedded in the articular surface of the rabbit femur with holes made according to the size, the joint was restored, and the incision site was sutured.

[0202] At this time, the material for regeneration of articular cartil...

Embodiment 2

[0230] A porous body made of hydroxyapatite with a porosity of 75% and a pore diameter of 200 μm was produced by stirring and foaming, and processed into a cylindrical body with a diameter of 4 mm and a length of 4 mm.

[0231] Cut the knee joint of the rabbit, and punch a hole with a diameter of 4mm on the articular surface of the femur. The hole is as deep as a part reaches the growth cartilage layer 3, and the obtained porous body is buried in the hole. The surface is deeper than the articular cartilage layer. 1mm, that is, the position of d=1mm in Figure 11, and then restore the joint, and then suture the incision site to achieve a movable state.

[0232] Five rabbits (n=5) were subjected to the above treatments.

Embodiment 3

[0234] The same porous body made of hydroxyapatite as in Example 2 was produced.

[0235] This porous body was buried at a place 2mm deeper than the articular cartilage layer on its surface, that is, the position of d=2mm in Fig. 11, and everything else was the same as in Example 2, and the rabbit's knee joint was treated.

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Abstract

The invention provides a material for regenerating the articular cartilage and the fabrication method. The material is characterized in that the material for regenerating the articular cartilage is well integrated with the neighboring articular cartilage under the environment close to the natural and grows in early period into the articular cartilage with the original thickness under the continuous state. The invention also provides a method to regenerate the cartilage inside or outside the organism and a cultivation method, further provides the man-made articular cartilage for transplanting. The method is characterized in that a material of hydroxyl phosphorite porous body with each pore communicating three-dimensionally through an opening section, porosity rate ranging from 50% to 90%, and the average diameter of the pore spanning from 100um to 600um is used to regenerate and cultivate the articular cartilage.

Description

technical field [0001] The present invention relates to a material for regeneration of articular cartilage, a method for producing the same, a method for regeneration and cultivation of articular cartilage, and artificial articular cartilage for transplantation. Or a method for regenerating articular cartilage in vitro, a method for cultivating articular cartilage, and artificial articular cartilage for transplantation using a ceramic porous body as a base material. Background technique [0002] A joint is a joint of movable joints between bones, and the surface of the mutual bone ends (articular surface) of this joint is covered with a layer of articular cartilage. Then, the periosteum of the mutual bone ends wraps the connecting part together to form the joint capsule. Between the bones covered by the joint capsule is a space called the joint cavity, which is filled with joint fluid. [0003] The aforementioned cartilage that forms the articular surface, usually, the thi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/56
CPCA61L27/12A61L2430/06A61L27/56
Inventor 吉川秀树名井阳玉井宣行
Owner 株式会社MMT 吉川秀树
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