Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Low-friction high-wear resistance bionic artificial joint and preparation method thereof

An artificial joint, low friction technology, used in tissue regeneration, prosthesis, coating and other directions, can solve the problems affecting the quality and service life of artificial joints, osteolysis and aseptic loosening, and the wear resistance needs to be improved. Reduced refurbishment and replacement frequency, stable hydrophilic wear layer, and improved wear resistance

Active Publication Date: 2016-08-24
NANJING UNIV OF SCI & TECH
View PDF3 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Abrasive debris produced by joint wear can lead to osteolysis and aseptic loosening, leading to failure of artificial joints and seriously affecting the quality and service life of artificial joints
[0003] Masayuki Kyomoto et al. directly grafted 2-methacryloyloxyethyl phosphorylcholine on the cobalt-chromium-molybdenum alloy, which can reduce the friction coefficient of the alloy surface in a short period of time, but the friction coefficient increases significantly when the friction cycle is longer. The surface graft layer is severely worn (Masayuki Kyomoto et al., Biomaterials, 2007, 28, 3121-3130)
Sun Yanmin and others used radio frequency plasma enhanced chemical vapor deposition technology to prepare DLC film on the surface of ultra-high molecular weight polyethylene (UHMWPE). Still needs to be improved (Sun Yanmin et al., China Surface Engineering, 2010,23(6):45-50)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Low-friction high-wear resistance bionic artificial joint and preparation method thereof
  • Low-friction high-wear resistance bionic artificial joint and preparation method thereof
  • Low-friction high-wear resistance bionic artificial joint and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0030] A method for preparing a low-friction and highly wear-resistant artificial joint of the present invention comprises the following steps:

[0031] In step 1, the sodium alginate is modified by a glycidyl methacrylate reaction method, and a carbon-carbon double bond is introduced into the sodium alginate.

[0032] The specific method is: add 0.54ml triethylamine to 250ml sodium alginate aqueous solution (0.2-0.5% (wt / v)), add 1.26g tetrabutylammonium bromide after magnetic stirring for one hour, and continue magnetic stirring for one hour Then add glycidyl methacrylate (3.32ml-16.62ml) so that the molar ratio of sodium alginate to glycidyl methacrylate is 1:10-50. React for 24 hours under magnetic stirring conditions, dialyze the product in deionized water with a dialysis bag with a molecular weight cut-off of 3500D for 6 days, and finally freeze-dry to obtain a modified sodium alginate sample;

[0033] In step 2, the modified sodium alginate is grafted on the surface of...

Embodiment 1

[0040] Add 0.54ml triethylamine to 0.2% (wt / v) sodium alginate aqueous solution, add 1.26g tetrabutylammonium bromide after magnetic stirring for one hour, continue magnetic stirring for one hour, then add glycidyl methacrylate 3.32 ml, so that the molar ratio of sodium alginate to glycidyl methacrylate is 1:10. The product was reacted for 24 hours under the condition of magnetic stirring, and the product was dialyzed in deionized water with a dialysis bag with a molecular weight cutoff of 3500D for 6 days, and finally freeze-dried to obtain a modified sodium alginate sample. Prepare an aqueous solution of 1g / L modified sodium alginate, put the ultra-high molecular weight polyethylene block material (UHMWPE) in the acetone solution (5mg / ml) of photosensitizer benzophenone, and keep it in the dark for 1min to make it The surface is coated with a photosensitizer, and dried in a dark room for 1 hour in vacuum; the sample coated with the photosensitizer is immersed in the above-me...

Embodiment 2

[0045] Add 0.54ml triethylamine to 0.3% (wt / v) sodium alginate aqueous solution, add 1.26g tetrabutylammonium bromide after magnetic stirring for one hour, continue magnetic stirring for one hour, then add glycidyl methacrylate 9.97 ml, so that the molar ratio of sodium alginate to glycidyl methacrylate is 1:20. The product was reacted for 24 hours under the condition of magnetic stirring, and the product was dialyzed in deionized water with a dialysis bag with a molecular weight cutoff of 3500D for 6 days, and finally freeze-dried to obtain a modified sodium alginate sample. Prepare an aqueous solution of 3g / L modified sodium alginate, put the ultra-high molecular weight polyethylene block material in the acetone solution (10mg / ml) of photosensitizer benzophenone, and keep it in the dark for 3min, so that the surface is coated The photosensitizer was vacuum-dried in a dark room for 1 h; the sample coated with the photosensitizer was immersed in the above-mentioned aqueous sol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Login to View More

Abstract

The invention discloses a low-friction high-wear resistance bionic artificial joint. A bearing interface of the artificial joint is modified with a modified sodium alginate cross-linked network structure and grafted with a hydrophilic polymer monomer, wherein the cross-linked network structure imitates the brush-like structure on the superficial layer of the natural joint cartilage and is formed by connecting modified sodium alginate to the substrate surface through a carbon-carbon double bond and through mutual cross-linking. The artificial joint is prepared by the following steps: grafting the substrate surface with sodium alginate modified by a glycidyl methacrylate reaction method; and grafting the cross-linked network structure of the modified sodium alginate with the hydrophilic polymer monomer. In the invention, by establishing the cross-linked network structure, the hydrophilic wearing layer on the joint surface is firmer, and the durability of the grafting layer is enhanced; and compared with the untreated substrate material, the friction coefficient can be reduced from 0.056 to 0.025, the surface contact angle can be reduced from 93 degrees to 14.2 degrees, the wear resistance is remarkably improved, the overhauling and replacing frequency of the artificial joint is reduced, and the service life of the artificial joint is prolonged.

Description

technical field [0001] The invention belongs to implant devices, in particular to a bionic artificial joint with low friction and high wear resistance and a preparation method thereof. Background technique [0002] There are a lot of free proteoglycans, proteoglycans and hyaluronic acid aggregates protruding from the superficial interface in the synovial cavity of the articular cartilage surface of natural joints. This brush-like structure has a strong hydration ability , can absorb synovial fluid in joints to form a hydration layer, effectively improve lubrication and reduce wear, making natural joints super-lubricating (J. Klein, Science, 2009, 323: 47-48). An artificial joint is an implanted prosthesis that replaces a damaged or diseased joint and restores its function. The wear debris produced by joint wear can lead to osteolysis and aseptic loosening, leading to failure of artificial joints and seriously affecting the quality and service life of artificial joints. [...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/34A61L27/18A61L27/16A61L27/50
CPCA61L27/16A61L27/18A61L27/34A61L27/50A61L2430/24C08L5/04
Inventor 刘昀彤王琨熊党生
Owner NANJING UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com