Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Joint-moving simulation test system with biological culture function

A technology of biological culture and joint movement, applied in the direction of biomass post-treatment, biomass pretreatment, biochemical cleaning device, etc., can solve the problems of cartilage performance limitations, achieve the effect of maintaining tissue activity and prolonging the test time

Inactive Publication Date: 2014-09-10
XI AN JIAOTONG UNIV
View PDF5 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing joint simulators can only simulate the kinematic environment of natural joints, so the research on cartilage performance is very limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Joint-moving simulation test system with biological culture function
  • Joint-moving simulation test system with biological culture function
  • Joint-moving simulation test system with biological culture function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The present invention will be further described in detail below in conjunction with specific embodiments.

[0026] see figure 1 , the present invention includes a joint simulator 1 and a biological culture circulation system; the biological culture circulation system includes a culture chamber 5, a peristaltic pump 7, an off-site sterilized glass fermenter 8 and a liquid storage tank 11 connected in sequence, the culture chamber 5 and the peristaltic pump 7, between the peristaltic pump 7 and the off-site sterilized glass fermenter 8, between the off-site sterilized glass fermenter 8 and the liquid storage tank 11, and between the liquid storage tank 11 and the culture chamber 5 through the silicone tube 6 Communication, the inlet and outlet of the liquid storage tank 11 are provided with shut-off valves 9 .

[0027] see Figure 2-4 , the culture chamber 5 is made up of a transparent upper chamber 13 and a transparent lower chamber 14 that can be communicated together...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a joint-moving simulation test system with a biological culture function, which comprises a joint simulator and a biological culture circulating system, wherein the biological culture circulating system comprises a culture cavity, a dislocated sterilized glass fermentation tank and a liquid storage tank which are sequentially communicated, the culture cavity is composed of an upper cavity and a lower cavity which are communicated together, the upper cavity is communicated with the dislocated sterilized glass fermentation tank, and the lower cavity is connected with an inlet of the liquid storage tank; the upper cavity is connected with a horizontal axis of the joint simulator, and the lower cavity is connected with a longitudinal axis of the joint simulator. According to the joint-moving simulation test system disclosed by the invention, the joint simulator can realize the moving control on the culture cavity, and the dislocated sterilized glass fermentation tank can realize the control on the oxygen, carbon dioxide, pH value and temperature of culture liquid in the circulating system. The joint-moving simulation test system disclosed by the invention not only can carry out in-vitro culture on tissue engineered cartilages, but also can efficiently carry out an in-vitro friction and wear performance evaluation test on active joint cartilages.

Description

technical field [0001] The invention relates to a motion simulation test system, in particular to a joint motion simulation test system with biological cultivation function. Background technique [0002] Tissue engineered cartilage has been developed so far. Although there are many experimental research results and a small amount of clinical application, both the function after culture and the long-term effect after implantation are unsatisfactory. How to improve the function of tissue engineered cartilage and how to evaluate the degree of its function before it can be implanted are the focus of attention now. An important factor in tissue engineered cartilage culture is mechanical stimulation. A large number of studies have shown that appropriate mechanical stimulation can increase the expression of cartilage matrix components such as collagen and polysaccharide protein, thereby improving the performance of tissue engineered cartilage. So far, the mechanical stimuli used ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12M3/00C12M1/38C12M1/36
CPCC12M21/08C12M23/34C12M23/58C12M29/18C12M41/12C12M41/26C12M41/32
Inventor 王玲朱祝山朱锦宇刘亚雄李涤尘靳忠民
Owner XI AN JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com