Method for preparing collagen protein/silica membrane double-layer stent
A collagen and collagen sponge technology, applied in the field of preparing collagen/silica membrane double-layer scaffolds, can solve the problems of poor mechanical properties, slow wound healing, poor degradation resistance, etc., achieve controllable size and thickness, and promote rapid healing , the effect of strong adhesion
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Embodiment 1
[0032] 0.5% collagen aqueous solution was freeze-dried into a collagen sponge with a size of 50×50×5 mm, and a thermal crosslinking system was used to crosslink the collagen sponge in a vacuum oven at 80° C. for 48 hours. After cross-linking, a layer of silica gel film was coated on the collagen sponge with a thickness of 0.5 mm, and cured at room temperature for 24 hours. After curing, the collagen / silica gel membrane double-layer scaffold is obtained. The properties of the prepared double-layer stents are shown in Table 1.
Embodiment 2
[0034]A 1% collagen aqueous solution was freeze-dried into a collagen sponge with a size of 50×50×4 mm, and a thermal crosslinking system was used to crosslink the collagen sponge in a vacuum oven at 90° C. for 60 hours. After cross-linking, a layer of silica gel film was coated on the collagen sponge with a thickness of 0.4 mm, and cured at room temperature for 24 hours. After curing, the collagen / silica gel membrane double-layer scaffold is obtained. The properties of the prepared double-layer stents are shown in Table 1.
Embodiment 3
[0036] A 1.5% collagen aqueous solution was freeze-dried into a collagen sponge with a size of 50×50×3.5 mm, and the collagen sponge was cross-linked in a vacuum oven at 100° C. for 72 hours by using a heat-crosslinking system. After cross-linking, a layer of silica gel film was coated on the collagen sponge with a thickness of 0.35 mm, and cured at room temperature for 24 hours. After curing, the collagen / silica gel membrane double-layer scaffold is obtained. The properties of the prepared double-layer stents are shown in Table 1.
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