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Hydroxyapatite/polyamide composite biological material with nanofiber cellular structure on surface and preparing method thereof

A technology of composite biomaterials and hydroxyapatite, applied in medical science, prostheses, etc., can solve the problem of difficult balance between tough material and bone tissue, unfavorable cell or tissue adhesion growth, bone regeneration and bone fusion, etc. Problems, to achieve the effects that are conducive to the growth of adhesion, the transportation of nutrients and the elimination of metabolic waste, and the effects of vascularization

Inactive Publication Date: 2015-08-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the surface of the product is non-porous and the specific surface area is small, it is not conducive to the adhesion and growth of cells or tissues after the product is implanted in the body, and it is also not conducive to the vascularization of the implant. The non-porous surface structure will also affect the transportation and metabolism of nutrients. Detrimental effects on the excretion of waste products, which in turn adversely affect bone regeneration and fusion
Moreover, the n-HA content of the interior and surface of the existing n-HA / PA composite product is the same. In order to increase the toughness of the product, it is often necessary to reduce the content of n-HA, but the reduction of the n-HA content in the product, It is not conducive to the combination of the product and bone tissue, and it is difficult to balance the toughness of the material and the bonding performance of the material and bone tissue

Method used

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  • Hydroxyapatite/polyamide composite biological material with nanofiber cellular structure on surface and preparing method thereof
  • Hydroxyapatite/polyamide composite biological material with nanofiber cellular structure on surface and preparing method thereof
  • Hydroxyapatite/polyamide composite biological material with nanofiber cellular structure on surface and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] In this example, the preparation method of the hydroxyapatite / polyamide composite biomaterial with nanofiber porous structure on the surface is as follows:

[0032] (1) Dissolving 3 g of n-HA / PA composite material and 5 g of calcium chloride with an n-HA content of 50 wt % in 100 mL of absolute ethanol solution to form a spinning solution; the n-HA content of 20 wt % / PA66 composite material is made into a tubular matrix with a diameter of 10mm and a length of 30mm;

[0033] (2) With the tubular substrate prepared in step (1) as the closing screen of electrospinning, the spinning solution is spun on the substrate by electrospinning to get final product; in this step, the control spinning voltage is 15KV, and the nozzle reaches The distance of the receiving screen is 15cm, the spinning speed is 0.3mL / h, and the spinning time is 20min.

[0034] The scanning electron micrographs of the surface of the composite biomaterial prepared in this embodiment are as follows: figur...

Embodiment 2

[0036] In this example, the preparation method of the hydroxyapatite / polyamide composite biomaterial with nanofiber porous structure on the surface is as follows:

[0037] (1) Dissolving 0.1g of n-HA / PA composite material with n-HA content of 65wt%, calcium chloride 1g in 100mL absolute ethanol solution to form spinning solution; n-HA content of 25wt% n- HA / PA66 composite material is made into a tubular matrix with a diameter of 20mm and a length of 30mm;

[0038] (2) With the tubular substrate prepared in step (1) as the closing screen of electrospinning, the spinning solution is spun on the substrate by electrospinning to get final product; in this step, the control spinning voltage is 15KV, and the nozzle reaches The distance of the receiving screen is 5cm, the spinning speed is 0.5mL / h, and the spinning time is 15min.

[0039] The scanning electron micrographs of the surface of the composite biomaterial prepared in this embodiment are as follows: figure 2 As shown, the ...

Embodiment 3

[0041]In this example, the preparation method of the hydroxyapatite / polyamide composite biomaterial with nanofiber porous structure on the surface is as follows:

[0042] (1) 5 g of n-HA / PA composite material with n-HA content of 65 wt %, calcium chloride 20 g are dissolved in 100 mL of absolute ethanol solution to form spinning solution; n-HA content of 25 wt % is n-HA / PA66 composite material is made into a tubular matrix with a diameter of 10mm and a length of 20mm;

[0043] (2) With the tubular substrate prepared in step (1) as the closing screen of electrospinning, the spinning solution is spun on the substrate by electrospinning to get final product; in this step, the control spinning voltage is 10KV, and the nozzle reaches The distance of the receiving screen is 30cm, the spinning speed is 0.7mL / h, and the spinning time is 30min.

[0044] The scanning electron micrographs of the surface of the composite biomaterial prepared in this embodiment are as follows: figure 2...

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Abstract

The invention provides a hydroxyapatite / polyamide composite biological material with a nanofiber cellular structure on the surface. The material is composed of a molding base body and a nanofiber layer which covers the surface of the molding base body and is combined with the molding base body integrally; nanofibers in the nanofiber layer are staggered to form the cellular structure, and the molding base body and the nanofiber layer are the hydroxyapatite / polyamide composite biological material. A preparing method includes the following steps: the hydroxyapatite / polyamide composite biological material and calcium chloride are dissolved into absolute ethyl alcohol to form a spinning solution; the molding base body is arranged on a receiving screen, and the spinning solution is coated on the molding base body in a spinning mode with an electrostatic spinning method, and the hydroxyapatite / polyamide composite biological material is obtained. By means of the hydroxyapatite / polyamide composite biological material, adherence growth of cells and tissues are facilitated, vascularization is easily achieved after the hydroxyapatite / polyamide composite biological material is implanted, and the combination performance between the hydroxyapatite / polyamide composite biological material and the bone tissues is good.

Description

technical field [0001] The invention belongs to the field of biological materials, and relates to a medical bone repair material, in particular to a hydroxyapatite / polyamide composite biological material with a nanofiber porous structure on the surface and a preparation method thereof. Background technique [0002] Nano-hydroxyapatite / polyamide (n-HA / PA) composite is a new medical composite material composed of nano-hydroxyapatite and polyamide. The n-HA / PA composite material is a kind of artificial bone material with good biomimetic properties. The organic phase polyamide (PA) is very similar to human collagen in molecular structure. The polar groups such as amide bond, carboxyl group and hydroxyl group in polyamide can guide the growth of tissue cells, promote the formation of osteoid and mineralization of cells, Accelerates the healing of bone injuries. In recent years, spinal replacement products made of n-HA / PA composite materials, such as laminae, bone cages, fusion ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56A61L27/50
Inventor 向钢李鸿辜刚旭张析严永刚吕国玉杨爱萍
Owner SICHUAN UNIV
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