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Composite hydrogel bracket, and preparation method and application thereof

A composite hydrogel and gel technology, applied in the medical field, can solve problems such as harmful to the human body, difficult to remove, and poor biocompatibility

Active Publication Date: 2021-04-02
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemically cross-linked hydrogels are cross-linked by covalent bonds to form gels, such as glutaraldehyde cross-linked polyvinyl alcohol, etc., usually need to add reagents such as cross-linking agents or initiators during the cross-linking process, which are harmful to the human body. Harmful, difficult to completely remove, when applied in the human body, although it has good mechanical strength, it has the problem of poor biocompatibility

Method used

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  • Composite hydrogel bracket, and preparation method and application thereof
  • Composite hydrogel bracket, and preparation method and application thereof
  • Composite hydrogel bracket, and preparation method and application thereof

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preparation example Construction

[0032] see figure 1 , the preparation method of the composite hydrogel scaffold of one embodiment, comprises the steps:

[0033] Step S110 : mixing medical grade sodium alginate, chondroitin sulfate, and carboxymethyl chitosan with the diluent to prepare a mixed solution.

[0034] Among them, alginic acid is a natural polyanionic polysaccharide, the most common of which is sodium alginate. Sodium alginate is widely used in the fields of food, medicine and tissue engineering due to its good biocompatibility, safety, non-toxicity, low cost and easy availability. Due to its good gel-forming properties and biological properties, it has become a common material for preparing hydrogels, and can usually be used as immobilization and embedding carriers for enzymes, proteins, animal and plant cells, and the like. In addition, alginate forms an open-lattice hydrogel through cross-linking in the presence of calcium ions, and the gel's lattice provides support for cells. Arranged growt...

Embodiment 1

[0062] The preparation process of the composite hydrogel scaffold of the present embodiment is as follows:

[0063] (1) Fully mix chondroitin sulfate A, medical grade sodium alginate (G / M is 45 / 55, viscosity is 400mpa.s) and carboxymethyl chitosan powder to obtain mixed raw materials, and then add phosphate buffer (pH 7.4), prepare the mixed solution. In the mixture, the mass fraction of chondroitin sulfate A is 1%, the mass fraction of medical grade sodium alginate is 4%, and the mass fraction of carboxymethyl chitosan is 2%.

[0064] (2) Put the mixed solution obtained in step (1) into a magnetic stirring water bath with a temperature of 60° C. and stir, and the stirring speed is 600 rpm / min, so that the mixed solution is fully mixed.

[0065] (3) Putting the homogeneously dissolved mixed solution obtained in step (2) into ultrasonic for defoaming treatment.

[0066] (4) Slowly adding a calcium chloride aqueous solution with a volume ratio of 1:10 to the defoamed mixed sol...

Embodiment 2

[0071] The preparation process of the composite hydrogel scaffold of the present embodiment is as follows:

[0072] (1) Fully mix chondroitin sulfate A, medical grade sodium alginate (G / M is 55 / 45, viscosity is 550mpa.s) and carboxymethyl chitosan powder to obtain mixed raw materials, and then add phosphate buffer (pH 7.4), prepare the mixed solution. In the mixture, the mass fraction of chondroitin sulfate A is 1.5%, the mass fraction of medical grade sodium alginate is 7%, and the mass fraction of carboxymethyl chitosan is 4%.

[0073] (2) Put the mixed solution obtained in step (1) into a magnetic stirring water bath with a temperature of 50° C. and stir, and the stirring speed is 500 rpm / min, so that the mixed solution is fully mixed.

[0074] (3) Putting the homogeneously dissolved mixed solution obtained in step (2) into ultrasonic for defoaming treatment.

[0075] (4) Slowly add a calcium chloride aqueous solution with a volume ratio of 1:8 to the defoamed mixed solut...

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Abstract

The invention relates to a composite hydrogel bracket, and a preparation method and application thereof. The preparation method of the above composite hydrogel bracket comprises the following steps of: mixing medical-grade sodium alginate, chondroitin sulfate and carboxymethyl chitosan with diluent to prepare mixed liquid; adding an aqueous solution containing water-soluble calcium salt into the mixed liquid, pouring into a mould, and standing for carrying out defoaming to prepare a hydrogel semi-finished product; and mixing the hydrogel semi-finished product with the aqueous solution of calcium carbonate, and preparing the composite hydrogel bracket. The preparation method of the above composite hydrogel bracket can prepare the composite hydrogel bracket which has a bone repairing effectand has high mechanical strength and good biocompatibility.

Description

technical field [0001] The invention relates to the medical field, in particular to a composite hydrogel stent and a preparation method and application thereof. Background technique [0002] With the development of human society, the disciplinary connection between medicine, life science and material science has become more and more close, resulting in biomedical polymer materials science. Among various biomedical polymer materials, polymer hydrogel is one of the research hotspots. Polymer hydrogel is a kind of polymer material that can absorb water, swell and retain water but does not dissolve in water. Due to the large amount of water contained in the polymer hydrogel network, the material as a whole has the characteristics of a fluid, which is very similar to the body tissue containing a large amount of aqueous solution. In addition, the flexible and moist surface of the polymer hydrogel and the affinity with the tissue greatly reduce the stimulation of the material to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/02A61L27/50A61L27/52A61L27/54A61L27/56
CPCA61L27/20A61L27/025A61L27/52A61L27/50A61L27/54A61L27/56A61L2300/236A61L2300/412A61L2430/02C08L5/04C08L5/08
Inventor 王大平赵月张华威
Owner SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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