5results about How to "Improve bone repair ability" patented technology

The invention provides a mesenchymal stem cell composition as well as a preparation method and application thereof in knee joint products, and belongs to the technical field of medicines. The invention relates to application of a mesenchymal stem cell combined naringin derivative in preparation of medicines for treating osteoporosis and repairing knee joint injury and arthritis. The naringin derivative is prepared from naringin through an ether esterification reaction, the metabolic cycle of the naringin derivative is prolonged and the water solubility is improved while the original activity is maintained, so that the free drug concentration and tissue infiltration capacity in bones are improved, the bioavailability of the naringin derivative is improved, and the bioavailability of the naringin derivative is improved. The prepared mesenchymal stem cell composition can induce mesenchymal stem cell osteogenic differentiation and improve bone repair capacity, has a good intervention effect on osteoporosis, has a sustained and controlled release effect and prolongs medicinal time.

The application discloses a kind of polyaryletherketone composite implant materials and preparation method and application, and belongs to medical material technical field, wherein, the preparation method of the polyaryletherketone composite implant material includes the following steps: preparation surface has recess structure and the carbon fiber reinforced polyaryletherketone base of conductivity;Based on precipitation method, white brushite is prepared using calcium compound, magnesium compound and phosphoric acid aqueous solution;White brushite is surface modified using polydopamine, to obtain modified white brushite;Modified white brushite is mixed with degradable piezoelectric polymer into solvent, to obtain mixed solution;Mixed solution is coated on carbon fiber reinforced polyaryletherketone base, after drying, annealing treatment, form coating, to obtain polyaryletherketone composite implant material.The application constructs white brushite doped degradable piezoelectric composite coating with piezoelectric characteristics and ion release capacity simultaneously, realizes the dual bionics of electric signal and chemical signal in bone healing microenvironment.

The present invention provides a montmorillonite-reinforced hybrid fiber-bonded 3D printed implant, which is composed of a 3D printed stent with a polydopamine coating and a montmorillonite-reinforced hybrid fiber, wherein the 3D printed stent with a polydopamine coating has mutually interpenetrating micrometer-level macropores, and the montmorillonite-reinforced hybrid fiber is bonded to the 3D printed stent with a polydopamine coating and distributed in the micrometer-level macropores of the 3D printed stent with a polydopamine coating, forming micrometer-level small pores in the micrometer-level macropores; the montmorillonite-reinforced hybrid fiber is formed by multiple chemical reactions of a polymer material having a catechol functional group, collagen and micrometer-level montmorillonite; the polydopamine coating on the surface of the 3D printed stent with a polydopamine coating and the montmorillonite-reinforced hybrid fiber are bonded together by multiple chemical bonds and intermolecular forces. The present invention also provides a preparation method of the above-mentioned implant and its application in the field of bone repair.

The invention discloses silk fibroin bone meal as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing water-soluble silk fibroin powder by adopting a spray drying method; carrying out post-treatment on the water-insoluble silk fibroin to obtain water-insoluble silk fibroin powder; carrying out biomimetic mineralization in calcium salt by taking silk fibroin as a template to prepare hydroxyapatite particles; the preparation method comprises the following steps: dispersing hydroxyapatite particles and water-insoluble silk fibroin powder into a silk fibroin solution, performing freeze-thaw cycle treatment on the obtained mixed solution, and drying to obtain a silk fibroin blocky material; and grinding into powder, and mixing with water-soluble silk fibroin powder to obtain the silk fibroin bone meal. The silk fibroin bone meal provided by the invention has the advantages of simple components, no immunoreaction or toxic risk, adjustable shape, different degradation rates, controllable pore structure and better tissue binding ability, and can effectively improve the bone tissue repair efficiency.

The application discloses a strontium-doped inorganic nanofiber composite 3D printing scaffold for bone defect repair and a preparation method thereof, and belongs to the field of bone defect repair biomaterials. The preparation method comprises the following steps: dissolving strontium nitrate in a mixed solution of tetraethyl orthosilicate, phosphoric acid and deionized water, stirring and mixing the obtained SiO2-SrO sol with a PVA solution, electrospinning, high-temperature calcination, obtaining a SiO2-SrO nanofiber membrane, cutting small pieces, high-speed stirring and dispersing, adding deionized water, high-speed homogenizing, freeze-drying, mixing with deionized water, grinding and freeze-drying, obtaining SiO2-SrO nanofiber as a dispersed phase, magnetically stirring and uniformly mixing CS solution and HA solution as a continuous phase, fully mixing and uniformly mixing to obtain a biological ink, and then 3D printing, freeze-drying and ultraviolet sterilization of the obtained scaffold, and immersion in a crosslinking agent solution for crosslinking reaction. The application realizes macroscopic and microscopic double-layer repair functions of the scaffold by combining electrospinning with 3D printing, and is used for bone defect repair.