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Bionic bio-active three-D porous composite material and making method thereof

A three-dimensional porous, composite material technology, used in medical science, coatings, prostheses, etc., can solve the problems of lack of biological activity, unsatisfactory three-dimensional structure of scaffolds, mismatch between biodegradation rate and cell growth rate, etc. , excellent cell affinity, low cost effect

Inactive Publication Date: 2005-11-09
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Bone and cartilage tissue engineering scaffold materials require good biocompatibility, controllable biodegradability, cell affinity, and suitable three-dimensional porous structure and mechanical properties. There are their own shortcomings, such as lack of biological activity, in vivo biodegradation rate does not match the cell growth rate, and the three-dimensional structure of the scaffold is not ideal, so finding and designing scaffold materials with better performance has always been an important research topic in the field of biomaterials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The first step is to grind the bioactive glass powder synthesized by the sol-gel method and sieve it to obtain ultrafine particles with a particle size of 10 microns;

[0020] In the second step, the porogen is ground and sieved to control the particle size between 100 and 200 microns;

[0021] The third step weighs the fully dried PHA, dissolves it in a certain volume of chloroform, and adds the sieved porogen and BG powder, wherein the weight ratio of the porogen to PHA is 10:1, and the weight ratio of BG to PHA is 10:1. The weight ratio is 1:8; the above components are fully stirred evenly to obtain a thick slurry;

[0022] The fourth step is to inject the above slurry into the pre-prepared special-shaped mold, pressurize at a constant temperature of 35°C, so that the porogen is evenly distributed in the system; place the mold in a natural ventilation environment to slowly evaporate the solvent; dry in vacuum Dry in the oven for 24 hours; open the mold to take out t...

Embodiment 2

[0026] In the first step, the bioactive glass powder synthesized by the sol-gel method is ground and sieved to obtain ultrafine particles with a particle size of 100 microns;

[0027] In the second step, the porogen is ground and sieved to control the particle size between 200 and 400 microns;

[0028] The third step weighs the fully dried PHA, dissolves it in a certain volume of chloroform, and adds the sieved porogen and BG powder, wherein the weight ratio of the porogen to PHA is 5:1, and the weight ratio of BG to PHA is 5:1. The weight ratio is 1:7; the above components are fully stirred evenly to obtain a thick slurry;

[0029] The fourth step is to inject the above slurry into the pre-prepared special-shaped mold, pressurize at a constant temperature of 35°C, so that the porogen is evenly distributed in the system; place the mold in a natural ventilation environment to slowly evaporate the solvent; dry in vacuum Dry in the oven for 24 hours; open the mold to take out th...

Embodiment 3

[0033] In the first step, the bioactive glass powder synthesized by the sol-gel method is ground and sieved to obtain ultrafine particles with a particle size of 100 microns;

[0034] In the second step, the porogen (sodium chloride, potassium chloride or sucrose, etc.) is ground and sieved to control the particle size between 500 and 700 microns;

[0035] The third step weighs the fully dried PHA, dissolves it in a certain volume of chloroform, and adds the sieved porogen and BG powder, wherein the weight ratio of the porogen to PHA is 2:1, and the weight ratio of BG to PHA The weight ratio is 1:1.5; the above components are fully stirred evenly to obtain a thick slurry;

[0036] The fourth step is to inject the above slurry into the pre-prepared special-shaped mold, pressurize at a constant temperature of 35°C, so that the porogen is evenly distributed in the system; place the mold in a natural ventilation environment to slowly evaporate the solvent; dry in vacuum Dry in th...

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Abstract

A bionic bioactive 3D porous composite material for repairing bone is prepared through respectively grinding bioactive glass powder and pore forming agent, sieving, dissolving PHA in chloroform, adding said powder, constant-temp pressing, drying, treating in circulating deionized water, and immersing in physiological solution. Its advantages are high bone repairing power, high porosity (90%), excellent cell affinity, bioactivity and controllable biodegradability, and low cost.

Description

(1) Technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a bionic bioactive three-dimensional porous composite material and a preparation method thereof. (2) Background technology [0002] The repair of bone and cartilage defects caused by trauma, infection, and tumor resection is a common clinical disease. Autologous bone transplantation is currently a common method for repairing bone defects. disease. Allogeneic bone and xenograft bone are antigenic, especially when repairing large bone defects, the transplantation often fails due to severe immune rejection, and there is also the risk of spreading diseases. In recent years, various metal and polymer materials have been used clinically to make bone replacement parts for bone defect repair, but these materials are inferior in terms of biocompatibility, bioactivity, biodegradability, and mechanical matching of the host bone. Each has its own disadvantages. Using the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/56A61L31/00C08J9/26C08L33/04
Inventor 郑裕东王迎军陈晓峰任耀彬陈中华吴刚
Owner SOUTH CHINA UNIV OF TECH
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