Preparation method and application of biological ceramic scaffold with hollow microsphere surface micro-nano structure

A technology of micro-nano structure and bioceramics, which is applied in the field of biomedical materials, can solve the problems of microsphere detachment, environmental pollution, and the inability to realize the tight connection between microspheres and scaffolds, and achieve the effect of simplifying the synthesis conditions

Active Publication Date: 2021-06-01
HARBIN INST OF TECH AT WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, the synthesis of hollow hydroxyapatite microspheres requires the use of organic solvents or mixed organic solvent reaction systems and the addition of surfactants or emulsifiers, which is costly and may cause pollution to the environment. In practical applications, residual Organic solvents may have an impact on the service effect
On the other hand, in terms of the stent-microsphere drug-loaded controlled release system, the microspheres are loaded onto the surface of the stent by soaking and coating the microsphere solution, which cannot realize the tight connection between the microspheres and the stent, and easily leads to the detachment of the microspheres.

Method used

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  • Preparation method and application of biological ceramic scaffold with hollow microsphere surface micro-nano structure
  • Preparation method and application of biological ceramic scaffold with hollow microsphere surface micro-nano structure
  • Preparation method and application of biological ceramic scaffold with hollow microsphere surface micro-nano structure

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Experimental program
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Effect test

Embodiment 1

[0029] The invention provides a method for preparing a bioceramic support with a micro-nano structure on the surface of a hollow microsphere, which comprises the following steps:

[0030] (1) Preparation of 3D printing bioceramic scaffold printing paste:

[0031] According to the parts by weight, weigh 1 part of sodium alginate, 0.5 part of polyvinyl alcohol, and 100 parts of distilled water, first dissolve polyvinyl alcohol in distilled water, then add sodium alginate, stir and mix evenly to obtain a premixed liquid; The ceramic printing slurry prepared by uniformly mixing the calcium powder and the premixed liquid according to the ratio of the final solid phase content of 58 wt%.

[0032] (2) Preparation of 3D printed bioceramic scaffold model:

[0033] The ceramic printing slurry prepared in step (1) is loaded into the barrel of the 3D printer, and the model to be printed is imported into the 3D printer software for printing. The diameter of the nozzle used by the printer ...

Embodiment 2

[0039]The invention provides a method for preparing a bioceramic support with a micro-nano structure on the surface of a hollow microsphere, which comprises the following steps:

[0040] (1) Preparation of 3D printing bioceramic scaffold printing paste:

[0041] According to the parts by weight, respectively weigh 2 parts of sodium alginate, 3 parts of polyvinyl alcohol, and 100 parts of distilled water, first dissolve polyvinyl alcohol in distilled water, then add sodium alginate, stir and mix evenly to obtain a premix; Calcium and calcium silicate powder and the premixed liquid are uniformly mixed according to the ratio of the final solid phase content of 45wt%, and the ceramic printing paste is prepared.

[0042] (2) Preparation of 3D printed bioceramic scaffold model:

[0043] The ceramic printing slurry prepared in step (1) is loaded into the barrel of the 3D printer, and the model to be printed is imported into the 3D printer software for printing. The diameter of the n...

Embodiment 3

[0049] The invention provides a method for preparing a bioceramic support with a micro-nano structure on the surface of a hollow microsphere, which comprises the following steps:

[0050] (1) Preparation of 3D printing bioceramic scaffold printing paste:

[0051] According to the parts by weight, respectively weigh 3 parts of sodium alginate, 3 parts of polyvinyl alcohol, and 100 parts of distilled water, first dissolve polyvinyl alcohol in distilled water, then add sodium alginate, stir and mix evenly to obtain a premix; Calcium acid calcium powder and the premix liquid are uniformly mixed according to the ratio of the final solid phase content of 40wt%, and the ceramic printing paste is prepared.

[0052] (2) Preparation of 3D printed bioceramic scaffold model:

[0053] The ceramic printing slurry prepared in step (1) is loaded into the barrel of the 3D printer, and the model to be printed is imported into the 3D printer software for printing. The diameter of the nozzle use...

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Abstract

The invention provides a preparation method and application of a biological ceramic scaffold with a hollow microsphere surface micro-nano structure, and solves the technical problem of how to realize the synergistic effect of a drug-loaded microsphere and a bone repair scaffold to obtain a scaffold-microsphere drug controlled release system in the prior art. A 3D printing biological ceramic scaffold and a hexametaphosphate solution are put into a hydrothermal reaction kettle to be subjected to a hydrothermal reaction, and after the hydrothermal reaction is completed, the biological ceramic scaffold with the hollow microsphere surface micro-nano structure is obtained, and the invention further discloses application of the biological ceramic scaffold with the hollow microsphere surface micro-nano structure, and the biological ceramic scaffold can be widely applied to the technical field of biomedical materials.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method and application of a bioceramic support with micro-nano structure on the surface of hollow microspheres. Background technique [0002] As we all know, the surface of bone repair scaffold materials is in direct contact with cells, and the surface properties of bone repair scaffold materials, such as micro-nano structure, hardness, hydrophilicity and hydrophobicity, and surface potential, can all affect stem cell differentiation, surface protein adsorption, early inflammatory response, cytoskeleton and Research on the micro-nano structure of the surface of bioactive ceramic scaffolds is an important way to improve their ability to promote osteogenesis and angiogenesis. To realize the regeneration of functionalized tissues, not only the supply of growth factors and nutrients in the scaffold is required, but also specific functional functions such as...

Claims

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Application Information

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IPC IPC(8): C04B38/06C04B35/447C04B35/622B33Y10/00B33Y70/10
CPCC04B38/067C04B35/447C04B35/622B33Y70/10B33Y10/00C04B2235/6026C04B2235/656C04B2235/6562C04B2235/6567C04B38/0645C04B38/0025
Inventor 张鹏刘康孙金平王传杰陈刚
Owner HARBIN INST OF TECH AT WEIHAI
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