22 results about "Bio ceramic" patented technology

The invention discloses a multi-ceramic-material 3D printing nozzle, device and method. The 3D printing nozzle designed by the invention can be adaptive to simultaneous extrusion and intermittent extrusion of one or more different biological ceramic slurries; the printing device comprises a 3D printing platform with an FDM printer as a main body, a discharging module combined with a printing nozzle and a pneumatic system, and a curing module composed of follow-up ultraviolet laser. Through a pulse strategy and relative pressure control and in combination with a laser-assisted curing technology, a runner invasion behavior (backflow) is overcome, construction of a biological ceramic scaffold with spatial heterogeneous material distribution is realized, and a new idea is provided for preparation of a multi-ceramic material bone repair scaffold.

The invention discloses a mesoporous biological ceramic filter sponge as well as a preparation method and application thereof, and belongs to the technical field of water treatment and air purification. The filtering sponge adopts a three-layer composite structure and comprises a three-dimensional porous sponge framework, a mesoporous ceramic transition layer and a nano metal thorn functional layer. Microorganism inactivation is achieved through a unique'adsorption-locking-puncturing 'physical mechanism, the inactivation rate of bacteria and viruses exceeds 99.9% under the condition that no chemical agent is used, meanwhile, heavy metal pollutants can be selectively removed, and beneficial mineral substances are reserved. The filtering sponge has the advantages of high porosity, large specific surface area, long service life and the like, and can be widely applied to the fields of drinking water treatment, sewage treatment, air purification and the like.

The invention relates to the technical field of biological ceramic materials, in particular to a zirconium oxide bone repair scaffold material with a porous interconnection structure and a preparation method of the zirconium oxide bone repair scaffold material. The invention aims to solve the problems of poor mechanical property and fragile interconnection structure of the existing stent under high porosity. The core preparation process comprises the following steps of: performing acetone steam annealing and pre-fusion on a double-particle-size microsphere template to form a stable interconnection window prototype; then, a continuous hole wall main body is constructed through vacuum impregnation of high-viscosity zirconium oxide slurry, and then secondary positioning reinforcement is conducted on the interconnected neck parts through low-viscosity nano zirconium oxide sol; finally, diluted bioactive glass sol is introduced to endow the surface with biological activity, and a final product is obtained through temperature-controlled degreasing and sintering. According to the method, the pore connectivity, the mechanical strength and the biological activity of the scaffold are synergistically optimized through template pre-fusion and partition sequential processes, and the method is suitable for repairing load-bearing bone defects.

The invention provides a porous biological ceramic hard tissue slice as well as a preparation method and application thereof. The preparation method of the porous biological ceramic hard tissue slice comprises the following steps: preparing a hydroxyl phospholime bone restoration specimen; dehydrating and transparentizing the hydroxyapatite bone restoration specimen; carrying out permeation and embedding on the hydroxyl phospholime bone restoration specimen; carrying out block trimming and slicing on the hydroxyl phospholime bone restoration specimen; mounting the hydroxyl phospholime bone restoration specimen; through the five steps, the porous biological ceramic hard tissue slice is obtained. According to the method, the defect that a tissue-material structure is easy to damage when a biological ceramic material is treated by a traditional hard tissue slicing technology is overcome; the improved hard tissue slicing technology is suitable for research of biological ceramic materials in bone tissue engineering application.

The invention relates to a bone-like layered calcium silicate / tricalcium phosphate heterogeneous biological ceramic as well as a preparation method and application thereof. The preparation method of the bone-imitating layered calcium silicate / tricalcium phosphate heterogeneous biological ceramic comprises the following steps: (1) mixing calcium silicate powder, an additive and a solvent to obtain calcium silicate tape casting slurry; mixing the tricalcium phosphate powder, an additive and a solvent to obtain tricalcium phosphate tape casting slurry; (2) respectively carrying out tape casting on the calcium silicate tape casting slurry and the tricalcium phosphate tape casting slurry to obtain a calcium silicate green tape and a tricalcium phosphate green tape; (3) alternately laminating the calcium silicate green tape and the tricalcium phosphate green tape, and performing pressurization treatment to obtain a composite ceramic body; and (4) degumming and sintering the composite ceramic green body to obtain the bone-like layered calcium silicate / tricalcium phosphate heterogeneous biological ceramic.

The invention provides photosensitive ceramic slurry and a photocuring 3D printing biological ceramic material as well as a preparation method and application thereof, and belongs to the technical field of medical biological materials. The photosensitive ceramic slurry provided by the invention is prepared from the following components in parts by mass: 50 to 55 parts of aluminum dihydrogen phosphate sol, 20 to 25 parts of ceramic powder, 10 to 15 parts of monomer, 0.05 to 0.10 part of photoinitiator, 0.01 to 0.05 part of stabilizer, 0.01 to 0.05 part of dye and 5 to 10 parts of water. A precursor obtained after 3D printing of the photosensitive ceramic slurry provided by the invention has the characteristics of free compression recovery, cutting and individualized filling of bone defect parts, flaws appearing in the printing process can be trimmed, and the precursor structure obtained after printing can be automatically recovered when slightly deformed; the problems that after 3D printing, the photosensitive resin is fixed in structure and cannot be freely compressed and cut are solved.

The invention relates to the field of biomedical materials, and discloses a preparation method of a collagen composite biological ceramic material. The method comprises the following steps: cleaning and drying a calcium phosphate ceramic matrix; immersing the ceramic matrix into the oligopeptide solution for adsorption, and irradiating under the condition of 220-300nm ultraviolet rays; sequentially immersing the ceramic matrix into a collagen solution with multi-stage gradient concentration; further immersing the ceramic substrate into a high-concentration collagen solution containing temperature-sensitive microgel particles; placing the soaked material in a mold with temperature gradient for directional freezing, and then performing freeze-drying treatment to obtain a finished product. Through the synergistic effect of short peptide pre-adsorption and UV low-energy irradiation, an interface enhancement layer with a mortise and tenon joint structure is constructed between the collagen coating and the ceramic matrix.

The invention provides a multifunctional artificial eye seat with polar radiation aperture distribution and a preparation method thereof, and belongs to the technical field of biomedical materials. The artificial eye seat is a porous spherical or ellipsoidal stent taking trace copper doped zinc melilite biological ceramic as a main component. The internal micropores are mutually communicated curved surface pore units, the pore diameters of the micropores are radially expanded from one end of the spherical surface to the opposite side in a macropore-mesopore-micropore gradient layout, a polar radiation pore diameter distribution three-dimensional bracket model is printed by adopting photocuring ceramic, and then the polar radiation pore diameter distribution three-dimensional bracket model is cleaned, dried and sintered to form the polar radiation pore diameter distribution three-dimensional bracket; the artificial eye seat gives consideration to the anatomical physiological structure of the orbit, the surface of the macropore area is attached to the deep soft tissue of the orbit, and the micropore area faces the ocular surface, so that vascularized soft tissue ingrowth is efficiently promoted, infection is durably resisted, common risks such as displacement and exposure of the artificial eye seat are effectively overcome, and the artificial eye seat has good application value in orbit reconstruction and reshaping.

The utility model relates to the technical field of disinfection of hydroxyapatite biological ceramics, in particular to a disinfection device of hydroxyapatite biological ceramics, which comprises a disinfection tank component, a high-pressure-resistant cover component and a base. A high-pressure-resistant cover assembly and a base are respectively arranged at the upper end and the lower end of the disinfection tank assembly. Through the arrangement of the water bath pot, the water vapor sterilization pot and the water vapor pot sealing cover, water in the tank body does not make direct contact with the water vapor sterilization pot when boiling, and then exchange of gas in the water vapor sterilization pot is achieved through the vent holes; therefore, the high-temperature and high-pressure water vapor can perform high-temperature sterilization on the hydroxyapatite biological ceramic placed in the water vapor sterilization pot, the hydroxyapatite biological ceramic sterilized by the high-temperature water vapor is not in direct contact with liquid water, and meanwhile, the contact amount of the high-temperature water vapor is increased; and high-temperature and high-pressure steam sterilization and disinfection are carried out on the premise of effectively protecting the hydroxyapatite biological ceramic.

The invention relates to a gutta-percha point raw material formula and a preparation method thereof. The gutta-percha point raw material formula comprises the following components by weight: 30-50% of a matrix material; 30-50% of a biological ceramic component; 5-15% of an antibacterial component; 5-10% of a toughening and bonding component; 1-5% of an auxiliary agent; the auxiliary agent is at least one of a coupling agent and a dispersing agent; the biological ceramic component can induce adhesion and proliferation of bone cells and promote mineralization, and has a bone tissue repair effect, and by adding the biological ceramic component, the bone tissue repair material has excellent biological activity and can promote periapical bone tissue repair; the antibacterial component provides a long-acting bactericidal performance, and by adding the antibacterial component, a patient is not easy to reinfect after an operation, so that the postoperative recurrence rate is reduced; the whole raw materials have excellent biocompatibility and sealing performance, the long-term stability of root canal filling can be improved, and leakage and treatment failure can be avoided.

The application discloses a plastic bone repair composite scaffold loaded with bone morphogenetic protein-2 and a preparation method thereof, and belongs to the technical field of biological repair materials. The preparation method comprises the following steps: mixing biological ceramic powder, modified starch and deionized water to obtain ceramic slurry through wet grinding, printing the ceramic slurry to obtain a biological ceramic scaffold blank, crushing the biological ceramic scaffold blank after sintering treatment to obtain biological ceramic particles; mixing the biological ceramic particles and a collagen fiber slurry, defoaming and then freeze-drying to obtain a ceramic collagen composite scaffold; placing the ceramic collagen composite scaffold into a crosslinking mixed solution for crosslinking, and then sequentially performing water washing, freeze-drying and sterilization to obtain a bone repair porous scaffold; and adding a CBD-rhBMP-2 solution dropwise to the bone repair porous scaffold to obtain the bone repair composite scaffold. The bone repair composite scaffold prepared by the method has good plastic stability and compressive strength, and has good osteogenic activity, and has practical use value.

The invention belongs to the field of biological materials, and relates to a pre-vascularized callus-like organ for accelerating tissue regeneration as well as a preparation method and application of the pre-vascularized callus-like organ. The pre-vascularized callus organ is a pre-vascularized callus organ which is formed by developing composite hydrogel microspheres loaded with silicate biological ceramics, human bone marrow mesenchymal stem cells and endothelial cells in an organ culture medium and has natural callus functional characteristics. Compared with organoids without silicate ceramics, the pre-vascularized callus organoids under regulation and control of silicate active ceramics show excellent endothelial network forming effect, osteogenic differentiation characteristic and mechanical response characteristic. In addition, the pre-vascularized callus-like organ shows more excellent mineralized matrix deposition capability. Therefore, the pre-vascularized callus-like organ regulated and controlled by the magnesium silicate ceramic can effectively accelerate the regeneration of bone tissues in vivo.

The application provides an automatic biological ceramic production monitoring system based on machine vision, compared with the prior art, the automatic biological ceramic production monitoring system comprises a camera device for acquiring images of biological ceramics in a furnace through an observation window, a monitoring module for receiving images shot by the camera device to judge the firing condition of the biological ceramics in the furnace, and a receiving module for receiving the biological ceramics fired in the furnace, the system combines image processing, automatic judgment and real-time monitoring and other technologies, effectively monitors and analyzes the change of the shape structure of the biological ceramics in the firing process, and makes the biological ceramic production process more stable and efficient.

The utility model discloses a water circulation atomization humidifier with sterilization structure in the technical field of atomization humidifier, and its structure is reasonable, the utility model discloses a connecting pipeline on the processing box is butted in the connecting pipe orifice on the water tank in the sliding mode, makes its positioning and connecting processing to the processing box, according to the processing tank after installation, can pour into water source, to the connecting pipeline enters into the water tank, through the circulating pump body in the sealing box, draws into the processing tank from the water inlet pipe, and then discharges to the sterilization tank from the water outlet pipe, according to the installation two groups of filter plates in the sterilization tank, and fill the activated carbon filter material, anion filter material and biological ceramic filter material between its two groups of filter plates in turn, then the activated carbon filter material, anion filter material and biological ceramic filter material carry out layer by layer sterilization and filtration treatment to the water source discharged from the water outlet pipe, and the water source filtered by sterilization is discharged to the water tank again through the connecting pipeline, forms water circulation effect, keeps the water source in the water tank active state.

The application belongs to the technical field of medical biological ceramic materials, and particularly relates to an oral cavity bone defect repairing material and a preparation method thereof. The material is prepared by compounding and consolidating hydroxyapatite, beta-tricalcium phosphate and surface calcium-phosphorus conversion modified low-sodium silicon-calcium-phosphorus bioactive glass particles; the bioactive glass is surface-activated by weak acid and low-temperature calcium-phosphorus conversion, and a calcium-phosphorus-silicate transition layer is formed on the surface of the particles. In the preparation, the inorganic components are wet ball-milled, granulated by polyvinyl alcohol, and low-temperature consolidated at 450-550 DEG C and 800-900 DEG C to remove the forming agent. The obtained material can reduce early pH fluctuation, improve interface compatibility, body fluid mineralization capacity, wet structure stability and degradation matching, and is suitable for repairing oral cavity local defects.

The invention discloses a ferromanganese Prussian blue analogue-loaded calcium phosphate double-layer structure tissue engineering material, which is prepared by the following steps: S1, carrying out photocuring 3D printing molding on matrix ceramic slurry to obtain a ceramic wet blank with a porous structure; s2, carrying out gradient sintering on the ceramic wet blank to obtain a porous ceramic preform; s3, nano calcium phosphate and a dispersing agent are fully mixed to obtain a nano calcium phosphate suspension, the porous ceramic preform is placed in the nano calcium phosphate suspension to be soaked and dried, and a double-layer porous ceramic wet blank is obtained; s4, rapidly sintering the double-layer porous ceramic wet blank to obtain the double-layer reinforced biological ceramic; and S5, soaking the double-layer reinforced biological ceramic in the Prussian blue analogue-calcium phosphate suspension, and drying to obtain the tissue engineering material of the calcium phosphate double-layer structure loaded with the ferromanganese Prussian blue analogue. The tissue engineering material disclosed by the invention has multiple effects of high mechanical property, large surface roughness, capability of effectively relieving inflammation, capability of improving bone induction performance and the like.

The invention discloses a porous biological ceramic artificial bone additive manufacturing method and system, and relates to the technical field of additive manufacturing, the sintering process is monitored, sintering state data is obtained, the deviation value of the sintering process is constructed after deviation analysis, and if the deviation value exceeds the expectation, the sintering process is determined. The trained sintering parameter control model is used for controlling sintering parameters, the sintered materials subjected to annealing treatment are tested to obtain quality data of the sintered materials, the trained quality identification model is used for evaluating the quality of the sintered materials, and the sintered materials are distinguished according to the obtained quality data; printing parameters are monitored in real time, if the printing parameters are abnormal, fault values are generated through continuously obtained abnormal data, and if the obtained fault values exceed expectation, the printing control parameters are optimized; and the cooling speed of the sintered material adapts to the actual environmental condition, the influence of the environmental condition on the sintering process is reduced, and the sintering effect is improved.

The invention provides a silicon-doped hydroxyapatite composite biological ceramic material and application thereof, and belongs to the technical field of biomedical materials. The silicon-doped hydroxyapatite composite biological ceramic material is prepared by compounding silicon-doped hydroxyapatite (SiHAp) and pure hydroxyapatite (HAp) according to the mass ratio of (1: 5) to (3: 3), wherein the silicon content in the SiHAp is 0.15-0.6 wt%. Through the synergistic effect of silicon doping modification and composite proportion optimization of hydroxyapatite and silicon-doped hydroxyapatite, on the premise of keeping high porosity and excellent biocompatibility, the compression strength is greatly improved, the mechanical property of the hydroxyapatite material is remarkably enhanced, and the application prospect is wide. And the method is particularly suitable for manufacturing bone tissue engineering scaffolds and bone repair implants.

The invention provides a multifunctional epicardial attaching device. The device comprises a hydrogel adhesion layer, a porous support layer and a conductive thin film layer which are sequentially arranged from bottom to top; wherein the surface of the hydrogel adhesion layer is provided with a plurality of biological ceramic spines arranged in an array, the biological ceramic spines penetrate through epicardial tissue to detect the ion concentration of heart cells in real time, and the hydrogel adhesion layer and the epicardial tissue are fixedly attached; the porous support layer is used for supporting the hydrogel adhesion layer and the conductive film layer, and the conductive film layer is electrically connected with the biological ceramic spines and used for converting the ion concentration detected by the biological ceramic spines into electric signals and transmitting the electric signals to in-vitro monitoring equipment; a micro cavity is formed in the porous bracket layer, and a first functional sheet and a second functional sheet are arranged in the micro cavity; the first functional piece and the second functional piece can be contacted and separated along with heartbeat and generate electric signals. According to the scheme, long-term, stable, continuous and real-time monitoring of the physiological parameters of the heart can be achieved.

The invention discloses zirconia biological ceramic with high toughness and high low-temperature aging resistance and a preparation method of the zirconia biological ceramic, and belongs to the technical field of preparation of ceramic-based composite materials. The preparation method of the biological ceramic comprises the following steps: dipping a green body in a mixed solution of aluminum nitrate, cerous nitrate and magnesium nitrate under negative pressure, then taking out and soaking in ammonia water, reacting aluminum nitrate, cerous nitrate and magnesium nitrate with ammonia water to obtain aluminum hydroxide, cerium hydroxide and magnesium hydroxide, then calcining to obtain aluminum oxide, cerium oxide and magnesium oxide, and repeatedly dipping to obtain the biological ceramic. Green bodies with different thicknesses can be obtained; and sintering the green body to obtain the zirconium oxide biological ceramic. By adopting a precursor dipping method, pressure stress is formed on the zirconium oxide surface layer, so that the strength, the fracture toughness and the low-temperature aging resistance of the zirconium oxide ceramic are improved.

The invention provides a gradient HA / ZrO2 biological ceramic preparation method and a biological ceramic, and relates to the technical field of ceramic material preparation. The method comprises the following steps: establishing sintering experiments under different solid contents and different component proportion combinations of HA and ZrO2 to obtain sintering shrinkage rate data, and establishing a sintering shrinkage rate regulation and control model; determining the composition proportion of each layer of the ceramic gradient structure according to biomechanical requirements; based on the composition proportion of each layer of the ceramic gradient structure, carrying out gradient structure reverse design by utilizing a sintering shrinkage rate regulation and control model to obtain the solid content required by each layer of the ceramic gradient structure; according to the solid content required by each layer of the ceramic gradient structure, HA / ZrO2 composite ceramic slurry with different solid contents is prepared, and the gradient HA / ZrO2 biological ceramic is prepared. According to the invention, equal shrinkage of the ZrO2-rich layer and the HA-rich layer can be realized during co-sintering, so that interlayer stress is eliminated fundamentally, and cracking and warping are avoided.

The invention belongs to the technical field of ceramic materials and additive manufacturing, and discloses a composite biological ceramic material and a preparation method thereof. The composite biological ceramic material is provided with m layers, and m is an odd number more than 3; raw material components for preparing the composite biological ceramic material comprise beta-tricalcium phosphate and hydroxyapatite, and the weight percentage content of the beta-tricalcium phosphate in each layer is distributed in a gradient increasing or decreasing manner from the bottommost layer to the outermost layer. The composite biological ceramic disclosed by the invention can be simply and quickly prepared without adding a sintering aid and applying sintering pressure. The prepared composite biological ceramic material contains beta-tricalcium phosphate in gradient distribution, and has good biological performance; and the hydroxyapatite is introduced as a second phase, so that excellent mechanical properties are obtained, and the compressive strength reaches 51 + / -0.22 MPa to 64 + / -0.70 MPa when the porosity is 45%.