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Method for preparing calcium polyphosphate / tricalcium phosphate two-phase biological ceramic

A technology of tricalcium phosphate and calcium polyphosphate, applied in the field of preparation of ceramic materials

Inactive Publication Date: 2009-04-15
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After searching the existing technical literature, it is found that the development of BCP composite bioceramic materials is mainly limited to HAP / β-TCP dual-phase composite ceramics

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1. Add Ca(H 2 PO 4 ) 2 ·H 2 O is heated up to 500°C, kept warm, then heated up to 1100°C with a heating rate of 10°C / min and kept warm to melt it, then quenched in cold water to obtain glassy amorphous CPP, ball milled, dried, and set aside.

[0028] 2. Amorphous CPP powder and HAP powder were mixed at a weight ratio of 0.12, and the mixed powder was ball milled with ethanol as a medium at a speed of 300 rpm for 12 hours, dried, passed through a 150-mesh sieve, and set aside.

[0029] 3. Weigh 10 grams of the above CPP / HAP mixed powder, put it into a mortar, add 3 milliliters of 2 wt % polyvinyl alcohol (PVA) aqueous solution, mix and granulate. Fill the granulated powder mm cylindrical stainless steel mold, after dry pressing, dry at 80°C for 3 days.

[0030] 4. The dried sample was sintered at 1200°C for 2 hours to obtain a dual-phase composite ceramic with a component composition of about 97wt% β-TCP and 3wt% amorphous CPP. The compressive strength is 150% of ...

Embodiment 2

[0032] 1. Add Ca(H 2 PO 4 ) 2 ·H 2 O is heated up to 500°C, kept warm, then heated up to 1100°C with a heating rate of 10°C / min and kept warm to melt it, then quenched in cold water to obtain glassy amorphous CPP, ball milled, dried, and set aside.

[0033] 2. Amorphous CPP powder and HAP powder were mixed at a weight ratio of 0.15, and the mixed powder was ball-milled with ethanol at a speed of 300 rpm for 12 hours, dried, passed through a 150-mesh sieve, and set aside.

[0034]3. Weigh 10 grams of the above CPP / HAP mixed powder, put it into a mortar, add 3 milliliters of 2 wt % polyvinyl alcohol (PVA) aqueous solution, mix and granulate. Fill the granulated powder mm cylindrical stainless steel mold, after dry pressing, dry at 80°C for 3 days.

[0035] 4. The dried sample was sintered at 1300° C. for 2 hours to obtain a dual-phase composite ceramic with a component composition of about 95 wt % β-TCP and 5 wt % amorphous CPP. The compressive strength is 250% higher tha...

Embodiment 3

[0037] 1. Add Ca(H 2 PO 4 ) 2 ·H 2 O is heated up to 500°C, kept warm, then heated up to 1100°C with a heating rate of 10°C / min and kept warm to melt it, then quenched in cold water to obtain glassy amorphous CPP, ball milled, dried, and set aside.

[0038] 2. Amorphous CPP powder and HAP powder were mixed at a weight ratio of 0.30, and the mixed powder was ball-milled with ethanol as a medium at a speed of 300 rpm for 12 hours, dried, passed through a 150-mesh sieve, and set aside.

[0039] 3. Weigh 10 grams of the above CPP / HAP mixed powder, put it into a mortar, add 3 milliliters of 2 wt % polyvinyl alcohol (PVA) aqueous solution, mix and granulate. Fill the granulated powder mm cylindrical stainless steel mold, after dry pressing, dry at 80°C for 3 days.

[0040] 4. The dried sample was sintered at 1350° C. for 2 hours to obtain a dual-phase composite ceramic with a component composition of about 82 wt % of β-TCP and 18 wt % of amorphous CPP. The compressive strengt...

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Abstract

The invention relates to a method for preparing calcium polyphosphate / tricalcium phosphate novel two-phrase biological ceramics in the technical field of biomedical materials, which comprises the following steps of: step one, using Ca(H2PO4)2 question mark H2O to prepare amorphous CPP powder; step two, mixing CPP and HAP according to the weight ratio of 0.12-0.30 to prepare mixed powder; step three, adding polyvinyl alcohol (PVA) aqueous solution to the powder sample, mixing and granulating; step four, conducting dry press forming; and step five, sintering the dried sample. By taking animal bone dust and monocalcium phosphate monohydrate as the raw material, the method optimizes the mixture ratio of the powder and the sintering temperature and obtains the calcium polyphosphate / tricalcium phosphate two-phrase biological ceramics with controllable two-phrase content and improved degradation performance.

Description

technical field [0001] The present invention relates to a method for preparing ceramic materials in the technical field of biomedical materials, in particular to a method for preparing calcium polyphosphate / tricalcium phosphate dual-phase bioceramics (β-TCP / CPP) by using natural bone powder and calcium polyphosphate method. Background technique [0002] Due to hydroxyapatite (HAP: hydroxyapatite, Ca 10 (PO 4 ) 6 (OH) 2 ) and tricalcium phosphate (β-TCP: calcium phosphate, Ca 3 (PO 4 ) 2 ) is close to the inorganic components of human bones, therefore, calcium phosphate ceramic materials have good application prospects in bone repair materials. In the past few decades, researchers have conducted extensive research on the application of this type of material in bone repair. HAP has excellent biocompatibility, osteoinductivity, and excellent mechanical properties, but poor biodegradability. β-TCP also has very good biocompatibility, and its mechanical properties are wo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622
Inventor 孙康李万万陈高祥
Owner SHANGHAI JIAO TONG UNIV
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