Porous magnesium alloy/biological ceramic bionic composite support and quick forming method thereof

A technology of bioceramics and composite scaffolds, applied in bone implants, medical science, prostheses, etc., can solve problems such as the mismatch between the strength degradation rate and the bone reconstruction process, insufficient mechanical strength and stability, etc., to achieve the solution of mechanical strength Insufficient stability and reduced contact area

Active Publication Date: 2012-01-25
XI AN JIAOTONG UNIV
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a rapid prototyping method for a porous magnesium alloy / bioceramic biomimetic composite scaffold to solve the problems of insufficient mechanical strength and stability in the early stage of bone scaffold implantation, and the mismatch between the strength degradation rate and the bone reconstruction process.

Method used

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  • Porous magnesium alloy/biological ceramic bionic composite support and quick forming method thereof
  • Porous magnesium alloy/biological ceramic bionic composite support and quick forming method thereof
  • Porous magnesium alloy/biological ceramic bionic composite support and quick forming method thereof

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Experimental program
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Effect test

Embodiment 1

[0023] 1) Firstly, according to the specific situation of the patient's bone defect site, the shape correlation and microstructure bionic design of the bone defect site are carried out with the help of reverse engineering and CAD technology, and the stress, internal deformation and hydromechanical characteristics of the bracket are analyzed using CAE analysis software. Structurally modified to form a CAD model of a biomimetic scaffold with an internal microstructure of interconnected primary and secondary two-stage pipelines;

[0024] 2) Mix deionized water, glycerin, organic monomer acrylamide, and cross-linking agent N, N-dimethylenebisacrylamide to form a premix, wherein the quality of glycerin accounts for 20% of the total mass of the premix, and the organic monomer The mass of the cross-linking agent and the monomer is 25%, the mass ratio of the cross-linking agent and the monomer is 1:8, and the balance is deionized water. Then, ceramic powder Beta-tricalcium phosphate (β...

Embodiment 2

[0028] Embodiment 2: In this embodiment, the bioceramic slurry is prepared according to the following method, and other steps are the same as in Embodiment 1:

[0029] Mix deionized water, glycerin, organic monomer methyl-acyloxyethyltrimethylammonium chloride, and cross-linking agent N, N-diacetonyl acrylamide to form a premix, wherein the mass of glycerin accounts for the total mass of the premix 20%, the quality of organic monomer accounts for 28%, cross-linking agent and monomer mass ratio are 1: 8, and balance is deionized water, then adds ceramic powder Alpha-tricalcium phosphate (α -TCP) and dispersant ammonium polyacrylate are prepared into ceramic slurry, wherein the volume ratio of the ceramic powder and the premixed liquid is 1: 1, and the dispersant content is 0.3% of the ceramic powder quality, and then poured into the ball mill jar in the ball mill After ball milling for 2 hours, adding a photoinitiator sodium persulfate whose mass is 1% of the mass of the premix...

Embodiment 3

[0030] Embodiment 3: In this embodiment, the bioceramic slurry is prepared according to the following method, and other steps are the same as in Embodiment 1:

[0031] 2) Mix deionized water, glycerin, organic monomer adipate dihydrazide, and cross-linking agent dibenzylidene acetonyl acrylamide to form a premix, wherein the quality of glycerin accounts for 20% of the total mass of the premix, and the organic monomer The mass of the body accounts for 26%, the mass ratio of the cross-linking agent and the monomer is 1:8, and the balance is deionized water, and then the ceramic powder apatite and the dispersant sodium polyacrylate are added batch by batch to the premix to prepare a ceramic slurry Material, wherein the volume ratio of the volume of the ceramic powder and the premixed solution is 1:1, the content of the dispersant is 0.3% of the mass of the ceramic powder, then poured into a ball mill jar and milled on a ball mill for 2 hours, and then added with a mass of 1% of th...

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Abstract

The invention relates to a porous magnesium alloy/biological ceramic bionic composite support and a quick forming method thereof. The quick forming method comprises the following steps of: performing appearance relativity, microstructural bionic design and structural optimization by means of reverse engineering and a computer-aided design (CAD) technology on the basis of analytical results of structures and biomechanics of different bone coloboma parts to establish a CAD model of the support; manufacturing a porous bioactive ceramic frame with two stages of pipelines which are not communicated mutually by a method for forming ceramics directly by photocuring; and casting molten magnesium alloy into a secondary pipeline of the biological ceramic frame by a vacuum suction casting method, cooling and solidifying to obtain the porous magnesium alloy/biological ceramic bionic composite support, wherein a primary pipeline is used for meeting the requirements of tissue growth and nutritionalmetabolism, and the magnesium alloy is filled into the secondary pipeline to enhance the mechanical property of the composite support and reduce a contact area of the magnesium alloy and body fluid, so that mass exchange of the magnesium alloy and a human body environment is avoided within a period of time of degrading ceramics to ensure the filled magnesium alloy provides continuous mechanical strength in the process of bone healing.

Description

technical field [0001] The invention belongs to the field of manufacturing engineering, in particular to a rapid prototyping method of a porous magnesium alloy / biological ceramic biomimetic composite support. Background technique [0002] Large-area bone defects caused by trauma, tumors, congenital deformities and other factors are clinical problems. According to statistics, more than 2.2 million bone defect repair operations are performed every year in the world, and about 3.5 million patients with bone defects or bone injuries are diagnosed in my country every year. There are more than 15 million patients with limb disorders nationwide, of which 3 million amputations due to lack of reconstructive surgery and bone replacement materials. The total market for individual bone matching in my country is at least 50 million yuan each year. Bone tissue engineering provides a new idea for the permanent repair of bone defects. The construction of bone tissue engineering scaffolds w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/50A61F2/28B22D19/00
Inventor 连芩李涤尘靳忠民刘亚雄贺健康李常海
Owner XI AN JIAOTONG UNIV
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