Preparation method and application of antibacterial bio-ceramic film with titanium or titanium alloy surface containing copper

A bioceramic membrane and titanium alloy technology, applied in surface reaction electrolytic coating, drug delivery, tissue regeneration, etc., can solve the problems of surface passivation film damage, large friction coefficient of titanium alloy, poor wear resistance, etc. Effects of abrasion and corrosion resistance, high biological activity and bacteriostatic properties, high protein adsorption capacity

Active Publication Date: 2015-06-03
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] (1) poor wear resistance
Compared with stainless steel, nickel-based alloys and other metal materials, titanium alloys have a larger friction coefficient and poor wear resistance, which makes it implanted in the human body to produce a large amount of black debris due to wear and tear, which can cause aseptic loosening and eventually lead to Implantation failure
[0004] (2) Corrosion resistance needs to be improved
However, due to the complexity of human body fluids, the surface passivation film may be damaged and dissolved, causing harmful substances to be released into the tissue
[0005] (3) Biological activity is not ideal
However, this method has long production cycle, high cost, great environmental pollution, and the coating is easy to deform.
[0010] Obviously, the above research work has achieved very meaningful results at a certain level, but the prepared coating has insufficient problems, and it is difficult to meet the actual production needs
In addition, under the guidance of the theory of osseointegration, although implant dentures have a very high success rate, there is also the problem of implant failure.

Method used

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  • Preparation method and application of antibacterial bio-ceramic film with titanium or titanium alloy surface containing copper
  • Preparation method and application of antibacterial bio-ceramic film with titanium or titanium alloy surface containing copper
  • Preparation method and application of antibacterial bio-ceramic film with titanium or titanium alloy surface containing copper

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1. Material preparation: After the pure titanium is cut and polished, it is cleaned and degreased by ultrasonic waves in acetone solution.

[0052] 2. Sandblasting: The silica sand particle size for sandblasting is 0.2mm, the compressed air strength is 0.2MPa, the surface roughness of the obtained substrate is Ra3.0μm, and the sandblasting equipment is RH-1010P high-pressure dry sandblasting machine.

[0053] 3. Chemical passivation: In the passivation solution, 40% (volume concentration) HF is 2ml / L, 70% (volume concentration) HNO 3 10ml / L, citric acid 1ml / L, and the rest is water. Temperature: room temperature, process for 2 minutes, immediately wash with tap water for 1 to 2 minutes after taking it out, and then wash with deionized water for 1 to 2 minutes, the thickness of the passivation film is 1 μm.

[0054] 4. Preparation of single forward square wave pulse micro-arc oxidation ceramic film: Electrolyte: calcium acetate with a concentration of 0.3mol / L, sodium g...

Embodiment 2

[0061] 1. Material preparation: After the pure titanium is cut and polished, it is cleaned and degreased by ultrasonic waves in acetone solution.

[0062] 2. Sandblasting: the silica sand particle size for sandblasting is 0.6mm, the compressed air strength is 0.6MPa, the surface roughness of the obtained substrate is Ra4.0μm, and the sandblasting equipment is RH-1010P high-pressure dry sandblasting machine.

[0063] 3. Chemical passivation: passivation solution: 40% (volume concentration) HF is 2ml / L, 70% (volume concentration) HNO 3 8ml / L, tartaric acid 2ml / L, and the rest is water. Temperature: room temperature, treat for 3 minutes, wash with tap water for 1 to 2 minutes immediately after taking it out, and then wash with deionized water for 1 to 2 minutes, the passivation film thickness is 1 μm.

[0064] 4. Micro-arc oxidation ceramic membrane preparation: Electrolyte: 0.2mol / L calcium acetate and 0.01mol / L calcium citrate, 0.01mol / L sodium dihydrogen phosphate, 0.005mol / L...

Embodiment 3

[0071] 1. Material preparation: Titanium alloy (Ti6Al4V) is cleaned and degreased by ultrasonic cleaning in acetone solution after cutting and grinding.

[0072] 2. Sandblasting: the silica sand particle size for sandblasting is 1.2mm, the compressed air strength is 0.5MPa, the surface roughness of the obtained substrate is Ra5.0μm, and the sandblasting equipment is RH-1010P high-pressure dry sandblasting machine.

[0073] 3. Chemical passivation: in the passivation solution, 70% (volume concentration) HNO 3 4ml / L, 70% (volume concentration) HNO 3 10ml / L, oxalic acid 1ml / L, and the rest is water. Temperature: room temperature, treat for 5 minutes, wash with tap water for 1 to 2 minutes immediately after taking it out, and then wash with deionized water for 1 to 2 minutes, the thickness of the passivation film is 1 μm.

[0074] 4. Micro-arc oxidation ceramic membrane preparation: Electrolyte: concentration of 0.1mol / L calcium glycerophosphate and 0.2mol / L calcium acetate, con...

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Abstract

The invention discloses a preparation method and application of an antibacterial bio-ceramic film with the titanium or titanium alloy surface containing copper and belongs to the technical field of treating metal surfaces. The preparation method comprises the following steps: preparing a Ca, P and Cu containing porous hard ceramic layer under a single square wave pulsed power supply mode; and carrying out hydrothermal treatment or alkali treatment to obtain the CuO/HA antibacterial bio-ceramic film. According to the preparation method disclosed by the invention, the prepared ceramic layer and a matrix are in metallurgical bonding and are good in bioactivity and obvious in antibacterial effect; the prepared antibacterial bio-ceramic film is suitable for dental implant in the field of oral cavities as well as bone union plates, bone nails and the like of orthopaedics; and the ceramic layer is good in protein adsorbability and adhesion, increment and differentiation abilities of cells and is capable of greatly shortening the bonding time of the traditional medical implanting material and bones.

Description

technical field [0001] The invention relates to the technical field of metal surface treatment, in particular to a preparation method and application of a copper-containing antibacterial bioceramic film on the surface of titanium or titanium alloy. Background technique [0002] With the advent of various new medical titanium alloys, titanium alloys are more and more widely used in the field of biomedicine. However, the titanium alloy materials that have been developed so far have defects in various degrees, and none of them can fully meet all the requirements for clinical use so far. Generally speaking, it is mainly manifested in the following aspects: [0003] (1) Poor wear resistance. Compared with stainless steel, nickel-based alloys and other metal materials, titanium alloys have a larger friction coefficient and poor wear resistance, which makes it implanted in the human body to produce a large amount of black debris due to wear and tear, which can cause aseptic loose...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26A61L27/40A61L27/54A61L31/12A61L31/16
CPCA61L27/06A61L27/32A61L27/54A61L27/56A61L31/022A61L31/086A61L31/146A61L31/16A61L2300/102A61L2300/404A61L2400/18A61L2420/02A61L2430/12C25D11/26
Inventor 张伟赵宝宏张涛张兵王福会
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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