3D printing bionic porous biological ceramic artificial bone and preparation method thereof

A bioceramic and artificial bone technology, applied in the field of bone repair materials, can solve the problems of difficult to achieve microporous bionic requirements, lack, difficult quantitative and precise control, etc., and achieve good biocompatibility, biodegradability, and good molding properties. , the effect of increasing the speed

Active Publication Date: 2020-04-28
西安点云生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because of its traditional preparation methods, such as gas foaming method, adding pore-forming agent method, particle sintering method, and organic foam impregnation method, although artificial bones with different pore sizes and porosity can be produced, there is a lack of control over pore size, pore size, and pore size. The regulation of parameters such as interconnectivity and pore space orientation can only achieve rough macroscopic control of parameters such as porosity and pore size, and it is difficult to quantitatively and accurately control key parameters such as the shape, size and distribution of pores, and it is even more difficult to realize micropores. It is also difficult to optimize and improve the design of the microscopic three-dimensional geometric configuration, and it is also difficult to manufacture a bionic porous artificial bone with macro-microstructure integration.
[0004] The analysis found that although the existing bionic artificial bone composite materials are similar to natural bone in composition, they differ greatly in microstructure

Method used

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  • 3D printing bionic porous biological ceramic artificial bone and preparation method thereof
  • 3D printing bionic porous biological ceramic artificial bone and preparation method thereof
  • 3D printing bionic porous biological ceramic artificial bone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] S1, preparation of PVA (polyvinyl alcohol) aqueous solution: take 4 g of polyvinyl alcohol powder, dissolve it in 46 g of water for injection, stir with a magnetic stirrer at a constant temperature of 95° C. for 1.5 h, and prepare an aqueous solution of polyvinyl alcohol with a mass fraction of 8%; The centrifuge centrifuges the solution twice at a speed of 3000rad / min, 5min / time, to remove impurities and obtain a uniform and transparent solution;

[0067] S2, preparation of bioceramic powder: Weigh 33.57g of hydroxyapatite powder and 22.38g of β-tricalcium phosphate powder, and mix the two evenly to obtain a uniform bioceramic powder; that is, hydroxyapatite and β-phosphoric acid The mass ratio of tricalcium is 3:2;

[0068] S3, according to the mass fraction, put 52.8% of the bioceramic powder obtained from S2 and the polyvinyl alcohol solution obtained from 47.2% of S1 into a homogenizer, first mix at 800 rad / min for 1 min, and then stir at 2000 rad / min for 4 Mix we...

Embodiment 2

[0080] S1, take 4g of polyvinyl alcohol powder, dissolve it in 46g of water for injection, stir it with a magnetic stirrer at a constant temperature of 95°C for 1.5h, prepare an aqueous solution of polyvinyl alcohol with a mass fraction of 8%, and centrifuge the solution twice with a centrifuge at 3000rad / min, 5min / time, to remove impurities and obtain a uniform and transparent solution;

[0081] S2, weighing 30 g of calcium silicate powder and 30 g of β-tricalcium phosphate powder, and mixing the two evenly to obtain a uniform bioceramic powder, that is, the mass ratio of calcium silicate to β-tricalcium phosphate is 1:1;

[0082] S3, according to the mass fraction, put 52.8% of the bioceramic powder obtained in S2 and 47.2% of the polyvinyl alcohol solution obtained in S1 into a homogenizer, first 800rad / min, premix for 1min, and then turn at 2000rad / min, Stir at high speed for 4 times to mix, each time for 1 minute, put the mixed slurry into the dispensing syringe, and use ...

Embodiment 3

[0093] S1, preparation of polyvinyl alcohol aqueous solution: dissolve polyvinyl alcohol powder in water for injection, prepare a polyvinyl alcohol aqueous solution with a mass fraction of 8%, stir at a constant temperature of 95°C for 1.5h on a magnetic stirrer, and then use a centrifuge at 3000rad / Centrifuge twice at 1 min speed, 5 min each time, to remove impurities and form a uniform transparent solution;

[0094] S2, in terms of mass fraction, put 52.8% of the bioceramic powder and 47.2% of the polyvinyl alcohol solution obtained in S1 into a homogenizer, pre-mix for 1 min at a speed of 800 rad / min, and then mix it with a speed of 2000 rad / min Rotate speed, stir 4 times to mix, each time stir for 1min, put the mixed slurry into the dispensing syringe, use the degassing machine to degas 6 times, get a uniform printable slurry, the silicic acid in the bioceramic powder Calcium: β-tricalcium phosphate mass ratio is 1:1;

[0095] S3, using the method of TPMS combined with C...

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Abstract

The invention discloses a 3D printing bionic porous biological ceramic artificial bone and a preparation method thereof. A porous biological ceramic artificial bone model is designed through a TPMS and CSG combined method, slurry capable of being used for printing is prepared through biological ceramic powder and a binding agent, macropores and micropores are distributed in the porous biological ceramic artificial bone prepared through the combination with the 3D filament-free printing process, the pore diameter of the micropores is smaller than 100 micrometers, the pore diameter of the macropores is 200-800 micrometers, the total porosity is 20% to 80%, the communicating rate between the macropores is not lower than 99%, precise design of porosity, communication and homogeneity in the artificial bone is achieved, and meanwhile good pore communication is ensured. Adopted raw materials have good biocompatibility, entry passageways of cells and tissue fluid are provided by the macropores, the micropores can better adsorb tissue fluid nearby for cell growth, the cell growth speed and the new bone generation speed can be increased by combining the micropores with the marcropores, and application of the porous biological ceramic artificial bone in human body large bone defect repair clinic treatment is facilitated.

Description

technical field [0001] The invention belongs to the field of bone repair materials, in particular to a 3D printed bionic porous bioceramic artificial bone and a preparation method thereof. Background technique [0002] In the treatment of orthopedic diseases, the repair of bone defects caused by trauma, infection, tumor resection and osteomyelitis has always been one of the difficult problems in this field. At present, artificial bone or bone particle materials are widely used in clinical practice to fill small-sized defects, but for large-scale bone defects, especially for the repair of large segments of limbs, autologous bone, allogeneic bone or xenograft bone is often used to transplant the defect into the patient's body. parts. However, the source of autologous bone is very limited, and the practice of tearing down the east wall to make up for the west wall will cause more trauma to the patient. However, allogeneic bone or xenograft bone transplantation has serious pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B28B1/00A61F2/28B33Y10/00B33Y50/02B33Y80/00
CPCA61F2/28A61F2002/2835A61F2002/30943A61F2002/30985B28B1/001B33Y10/00B33Y50/02B33Y80/00
Inventor 曾庆丰李建宾魏静杨彦召杨智宇益明星
Owner 西安点云生物科技有限公司
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