Preparation methods of ceramic slurry for air pressure extrusion type three-dimensional printing and biological ceramic bracket

A technology of three-dimensional printing and ceramic slurry, which is applied in the direction of ceramic molding machines, clay preparation devices, chemical instruments and methods, etc. low shrinkage effect

Active Publication Date: 2015-12-30
广州康睿医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Another object of the present invention is to provide a three-dimensional scaffold with 100% connectivity, controllable external structure and internal size, which can be used to prepare bioactive ceramic scaf

Method used

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  • Preparation methods of ceramic slurry for air pressure extrusion type three-dimensional printing and biological ceramic bracket
  • Preparation methods of ceramic slurry for air pressure extrusion type three-dimensional printing and biological ceramic bracket
  • Preparation methods of ceramic slurry for air pressure extrusion type three-dimensional printing and biological ceramic bracket

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Step 1: Preparation of high solid content slurry

[0040] (1) The micronano-scale spherical β-tricalcium phosphate (β-TCP) powder synthesized by the soluble calcium salt and phosphate reaction process is used as the raw material, and the mixed solution of deionized water and ammonium polyacrylate is used as the solvent. Planetary ball mill ball milling 8h (frequency 30Hz), preparation of slurry with a solid phase content of 45vol%, its rheological properties and viscosity see figure 1 ;

[0041] (2) Add methyl cellulose with a high degree of polymerization into the slurry as a rheological additive, the amount added is 1 wt% of the β-TCP powder, and use a planetary ball mill for high-speed ball milling for 2 hours, and then move the slurry into a barrel. By means of ultrasonic vibration (frequency 100Hz, time 30min, temperature 30°C) and low temperature defoaming (time 12h, temperature 4°C), a bioactive ceramic slurry that can be used for 3D printing is prepared, and th...

Embodiment 2

[0052] Step 1: Preparation of high solid content slurry

[0053] (1) The micro-nano-scale spherical hydroxyapatite (HA) powder synthesized by the reaction process of soluble calcium salt and phosphate was used as the raw material, and the mixture of deionized water and sodium polyacrylate was used as the solvent, and the ball was milled for 8 hours using a planetary ball mill. (Frequency 30Hz), preparing a slurry with a solid phase content of 50vol%;

[0054] (2) Add low-melting point agarose to the slurry as a rheological additive in an amount of 2.5 wt% of the HA powder, use a planetary ball mill for high-speed ball milling and mix for 1 hour, and then move the slurry into a barrel. By means of ultrasonic oscillation (frequency 100Hz, time 30min, temperature 30°C) and low temperature standing (time 12h, temperature 4°C), a bioactive ceramic slurry that can be used for 3D printing is prepared, and the viscosity of the slurry is lower than 100Pa ·S, the solidification time in...

Embodiment 3

[0063] Step 1: Preparation of high solid content slurry

[0064] (1) Using nano-scale bioactive glass (BG) powder synthesized by sol-gel method as raw material, using a mixture of deionized water and stearic acid as solvent, using a planetary ball mill for 3h (frequency 30Hz), the preparation of solid A slurry with a phase content of 40vol%;

[0065] (2) Add xanthan gum with a high degree of polymerization into the slurry as a rheological additive, the addition amount is 2wt% of the powder, use a planetary ball mill for high-speed ball milling and mix for 1 hour, and then move the slurry into a barrel. By means of ultrasonic vibration (frequency 100Hz, time 30min, temperature 30°C) and low temperature standing (time 12h, temperature 2°C), the bioactive ceramic slurry for 3D printing was prepared; the viscosity of the slurry was lower than 100Pa· S, the solidification time in air is less than 1 minute.

[0066] Step 2: Preparation of three-dimensional controllable microstruct...

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Abstract

The invention discloses a preparation method of ceramic slurry for air pressure extrusion type three-dimensional printing. The preparation method comprises the following steps: (11) adding biological active ceramic powder into a solvent, performing ball grinding by a planetary ball grinder for 3 to 12 hours, and obtaining slurry, wherein the solid phase content of the slurry is 35 to 55 vol%; (12) adding a water-soluble rheological additive into the slurry obtained in the step (11), performing ball grinding by the planetary ball grinder for 0.5 to 3 hours, then transferring the slurry into a material feeding barrel, performing ultrasonic oscillation and low-temperature debubbling in sequence, and obtaining the ceramic slurry for air pressure extrusion type three-dimensional printing. The invention further discloses a preparation method of a biological active ceramic bracket by adopting an air pressure extrusion type three-dimensional printing forming technology. The ceramic slurry prepared by the preparation method disclosed by the invention is high in solid phase content and good in printing performance and coagulability; the prepared biological active ceramic bracket can be connected by 100 percent, and the appearance structure and the internal size of the biological active ceramic bracket can be controlled.

Description

technical field [0001] The invention relates to material preparation of rapid prototyping technology, in particular to a method for preparing ceramic slurry and bioceramic support for pneumatic extrusion three-dimensional printing. Background technique [0002] The current bone repair technology mainly includes autologous and allogeneic bone grafting technology: autologous bone contains living osteoblasts and bone morphogenic proteins that can induce osteogenesis, and has no immune rejection, which is the "gold" standard for clinical bone defect treatment. However, the source is limited and cannot be used for the treatment of large segmental bone defects; allograft bone transplantation has the advantages of biological characteristics and morphological structure similar to autologous bone, but the source of allograft bone is limited, and it is prone to immune rejection. Risk of spreading certain diseases. [0003] In order to solve the problem of repairing human tissue and o...

Claims

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Application Information

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IPC IPC(8): B28B1/00B28B11/24B28C5/00C04B35/622B33Y10/00B33Y70/00
CPCB28B1/001B28B11/243B28C5/003C04B35/622
Inventor 赵娜如马艺娟王迎军刁静静
Owner 广州康睿医疗器械有限公司
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