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Preparation method of hydroxyapatite/zirconium dioxide biological ceramic composite material and its products

A technology of hydroxyapatite and compound hydroxyapatite, which is applied in the field of medical materials, can solve the problems of low strength, high brittleness, limited bioceramic medical materials, etc., achieve good strength and toughness, good strength and toughness, and promote proliferation. and the effect of differentiation

Inactive Publication Date: 2005-11-23
HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydroxyapatite (Hydroxyapte referred to as HAP), its chemical composition and structure are similar to those of bones and teeth, and has good biocompatibility with body tissues. When combined with bone, it can promote osteoinduction at the interface. grow and grow into the micropores to form a physiological combination, but the existing biomedical materials have a great weakness, that is, low strength and high brittleness, which severely limits the clinical application of bioceramic medical materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: This embodiment prepares hydroxyapatite / zirconia bioceramic composite material, including the following steps:

[0022] 1. Zirconium dioxide (ZrO 2 ) preparation of superfine powder:

[0023] The raw materials used are analytically pure and prepared by chemical co-precipitation method. First prepare Y 3+ / Zr 4+ The ratio of yttrium chloride (Y 2 o 3 +HCl) and zirconium oxychloride mixed solution; slowly add the mixed solution into ammonia water, and keep stirring to keep the pH value of the system greater than 9.5, obtain coprecipitate after static precipitation, filter the coprecipitate, and then wash with distilled water , remove chloride ions until the concentration of chloride ions is less than 10ppm, then wash with ethanol 8 times, remove water, make the water content less than 4vol / L and dry to obtain a loose hydroxide precursor, and finally calcined at 750°C for 2 hours to obtain 3% mol Y 2 o 3 Stable ZrO 2 (Y 2 o 3 ) superfine powder.

...

Embodiment 2

[0028] Embodiment 2: In this embodiment, hydroxyapatite / zirconia bioceramic composite material is prepared, and zirconium dioxide is used to simply compound hydroxyapatite when the green body is formed, including the following steps:

[0029] 1. Zirconium dioxide (ZrO 2 ) preparation of superfine powder:

[0030] The preparation process is the same as in Example 1.

[0031] 2. Preparation of hydroxyapatite powder:

[0032] The preparation process is the same as in Example 1.

[0033] 3. Combine the HAP powder obtained in the above steps with Y 2 o 3 Partially stabilized ZrO 2 (Y 2 o 3 ) using a simple composite method, symmetrically pave HAP on the surface of the ZrO2 substrate, then pressurize to form a green body, and then place it in a high-temperature furnace and sinter without pressure at 1600 ° C for 3 hours.

experiment example 1

[0035] 1. Preparation of materials: sterilize the hydroxyapatite / zirconia bioceramic composite material prepared in the example with ethylene oxide, and then put it into normal saline at the ratio of 1g material / 5ml medium, at 37°C Stand and extract in a constant temperature box for 72 hours, filter and sterilize, and store in a refrigerator at 4°C for later use.

[0036] 2. In vitro acute systemic toxicity test:

[0037] Select 30 healthy male mice of about 20 g, randomly divide them into 3 groups, 10 mice in each group, and record the initial body weight. The mice in the test group were intravenously injected with the saline extract of the material sample, and the injection volume for each mouse was 50 g / kg; the mice in the control group were injected with the same batch of saline as the extraction solution, and the dose was the same as that of the test group. Immediately, 4, 24, 48 and 72 hours after injection, observe the general state, toxicity and death of the mice, obs...

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Abstract

The invention relates to a preparation method of hydroxyapatite / zirconium dioxide biological ceramic composite material which comprises preparing zirconium dioxide super fine, then preparing hydroxyapatite powder, and loading zirconium dioxide super fine and hydroxyapatite powder into die casting arrangement, pressurizing to obtain blanks, then placing into high temperature furnace for burning. The preparing material has good biocompatibility and high strength and tenacity.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a method for preparing a hydroxyapatite / zirconia bioceramic composite material and a product thereof. Background technique [0002] The application of biological materials in medicine has a long history. In recent years, with the development of science and the improvement of surgical medical level, a series of metal medical biological materials such as stainless steel, cobalt-chromium alloy, industrial pure thorium and titanium alloy have been developed successively. Material. Metal medical biomaterials have good mechanical properties, but when the metal medical biomaterials are implanted into the human body and interact with proteins and amino acids in body fluids and blood, the metal surface will corrode, causing metal ions to enter the body, or metal ions and The combination of biological atoms can cause poisoning or allergy to the human body. This ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/14
Inventor 全仁夫吴晓春汪宏斌谢利军季伟
Owner HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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