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Calcium silicate/hydroxylapatite composite biological ceramic material and preparation method and application thereof

A composite bioceramic and hydroxyapatite technology, applied in medical science, prosthesis, etc., can solve the problems of high purity requirements, long time-consuming, poor degradability of biological materials, etc., and achieve the effect of controllable mechanical strength

Inactive Publication Date: 2010-05-05
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, A-W glass-ceramic materials have poor degradability, and in vivo implantation experiments show that A-W bioactive glass-ceramics can exist stably in vivo for more than 10 years [J.Bone Jt.Surg.71A:264; 1989.]
Therefore, A-W glass-ceramic materials are greatly limited in the field of tissue engineering scaffolds and clinical applications with high degradability requirements
In addition, A-W glass ceramics also have the following disadvantages: (1) The material is prepared using a high-temperature melting process, which has the disadvantages of high preparation temperature, long time consumption, and high energy consumption
At the same time, the crushing and ball milling process requires the use of ball milling media such as zirconia or alumina, which is very easy to introduce impurities, and biological materials have extremely high requirements for purity.
Studies have shown that as long as a very small amount of Al is infiltrated into A-W glass ceramics 2 o 3 , leading to the loss of biological activity of A-W bioglass [J.Biomed.Mater.Res.24:331-343; 1990.]
(3) The composite ratio of hydroxyapatite phase and wollastonite phase is single, which makes it difficult to control its mechanical strength, degradability and biological activity
(4) A-W glass ceramics are difficult to prepare as porous scaffold materials for tissue engineering with good degradability
[0009] In summary, there is a lack of a composite bioceramic material with adjustable composite ratio of hydroxyapatite and calcium silicate and good and controllable comprehensive properties such as biological activity, degradability and mechanical strength.

Method used

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  • Calcium silicate/hydroxylapatite composite biological ceramic material and preparation method and application thereof
  • Calcium silicate/hydroxylapatite composite biological ceramic material and preparation method and application thereof
  • Calcium silicate/hydroxylapatite composite biological ceramic material and preparation method and application thereof

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Embodiment 1

[0046] The powder raw material preparation method used is as described above. Take 58.80 grams of Ca(NO 3 ) 2 Dissolved in 500mL deionized water, and adjusted to pH=11 with 1:1 ammonia water, 19.73 grams of (NH 4 ) 2 HPO 4 Dissolve in 500mL deionized water to get (NH 4 ) 2 HPO 4 aqueous solution. The above (NH4 ) 2 HPO 4 The aqueous solution was added dropwise to the Ca(NO 3 ) 2 In the solution, the pH value of the reaction system was maintained at 11 with a 1:1 ammonia solution during the feeding process, and the stirring was continued for 24 hours after the addition, and the hydroxyapatite nano-powder was obtained by filtration, and the hydroxyapatite nano-powder was dispersed in 500 mL to remove deionized water, and dissolved 50.89 g Ca(NO 3 ) 2 , to obtain a white suspension dispersed with hydroxyapatite nanopowder; 500mL of pH 11.0 and 61.25g of Na 2 SiO 3 The aqueous solution was added dropwise to the above suspension, and the pH of the reaction system was...

Embodiment 2

[0052] The powder raw material preparation method used is as described above. Take 211.68 grams of Ca(NO 3 ) 2 Dissolved in 1800mL deionized water, and adjusted to pH=11 with 1:1 ammonia water, 71.01g of (NH 4 ) 2 HPO 4 Dissolve in 1000mL deionized water to get (NH 4 ) 2 HPO 4 aqueous solution. The above (NH 4 ) 2 HPO 4 The aqueous solution was added dropwise to the Ca(NO 3 ) 2 In the solution, the pH value of the reaction system was maintained at 11 with a 1:1 ammonia solution during the feeding process, and the stirring was continued for 24 hours after the addition, and the hydroxyapatite nano-powder was obtained by filtration, and the hydroxyapatite nano-powder was dispersed in 200 mL to remove ionized water, and dissolved 20.36 g Ca(NO 3 ) 2 , to obtain a white suspension dispersed with hydroxyapatite nanopowder; 200mL of pH 11.0 and 24.50 Na 2 SiO 3 The aqueous solution was added dropwise to the above suspension, and the pH of the reaction system was kept ...

Embodiment 3

[0058] The powder raw material preparation method used is as described above. Take 23.52 grams of Ca(NO 3 ) 2 Dissolved in 200mL of deionized water, and adjusted to pH=11 with 1:1 ammonia water, 7.89g of (NH 4 ) 2 HPO 4 Dissolve in 120mL deionized water to get (NH 4 ) 2 HPO 4 aqueous solution. The above (NH 4 ) 2 HPO 4 The aqueous solution was added dropwise to the Ca(NO 3 ) 2 In the solution, the pH value of the reaction system was maintained at 11 with a 1:1 ammonia solution during the feeding process, and the stirring was continued for 24 hours after the addition, and the hydroxyapatite nano-powder was obtained by filtration, and the hydroxyapatite nano-powder was dispersed in 1800mL to remove ionized water, and dissolved 183.24 g Ca(NO 3 ) 2 , to obtain a white suspension dispersed with hydroxyapatite nanopowder; 800mL of pH 11.0 and dissolved with 220.50g of Na 2 SiO 3 The aqueous solution was added dropwise to the above suspension, and the pH of the react...

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Abstract

The invention relates to a calcium silicate / hydroxylapatite composite biological ceramic material and a preparation method and application thereof, belonging to the field of biological materials. Calcium silicate / hydroxylapatite nano composite powder prepared by a chemical method is used as a raw material and carried out the dry pressing and molding to obtain a material biscuit, and the biscuit is calcined at 1000-1200 DEG C for 1-10 hours to obtain a degradable calcium silicate / hydroxylapatite composite biological ceramic material which has good mechanical properties and is used for repairing the defects of hard tissues. The biological activity, the degradability and the mechanical strength of the biological ceramic material of the invention can be adjusted and controlled. The invention has simple and easy processes and convenient popularization.

Description

technical field [0001] The invention relates to a calcium silicate / hydroxyapatite composite bioceramic material, a preparation method and application thereof, and belongs to the field of biomaterials. Background technique [0002] Professor Hench, a famous biomaterials scientist, pointed out that the third-generation biomaterials should not only satisfy the characteristics of biological activity, but also be degradable [Science 295:1014-1017; 2002]. At the same time, the material should also be able to induce tissue regeneration during the degradation process [Nature Mater., 8: 457-470; 2009]. This is also the basic requirement for the development of third-generation biomaterials. [0003] In terms of inorganic biomedical materials for repairing hard tissue injuries, calcium phosphate-based Ca-P-based biomaterials and bioglass-based Ca-Si-based biomaterials are the most researched and clinically applied materials. Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 , HAp] and β-tri...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/12A61L27/02A61L27/56
Inventor 常江林开利金晓刚
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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