40results about How to "Biological activity has" patented technology

A process for preparing a bioactive polylactic acid from the maleic acid anhydride modified polylactic acid includes directly adding organic diamine, diol, hydroxyamine, or water, reacting, separating and purifying the resultant, adding polyethanediol and bioactive substance, and reacting under action of organic cross-linking agent to obtain target product. The target product can be used as the scaffold of tissue engineery and the slow-releasing target carrier of medicine.

The invention discloses a preparation method of a dental bioactive zirconia ceramic material. The preparation method comprises steps as follows: with adoption of a method for preparing bioactive glass from sol-gel, a hydrolysable silicone-containing compound, triethyl phosphate, calcium nitrate, other nitrates and the like are added to deionized water, pH is regulated, a mixed solution is subjected to hydrolytic condensation, and bioactive glass sol is obtained; after being soaked in the prepared bioactive glass sol in a vacuum negative-pressure environment for a period of time, a zirconia pre-sintered body is taken out, dried and sintered at the high temperature, and the dental bioactive zirconia ceramic material is obtained. The bioactive zirconia ceramic material has good biological activity and excellent mechanical properties and has great social and economic value in improvement of the dental material repairing effect and promotion of wider clinical application of the material.

Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.

The invention discloses a method for extracting natural bioactive protein from unpolished rice or / and rice bran. The method comprises the followings: processing unpolished rice or / and rice bran to obtain degreased rice flour; mixing degreased rice flour and soduim chloride water, then extracting through oscillation, and collecting supernatant fluid through first separation, namely total salt soluble protein solution is obtained; adding alcohol into the total soluble protein solution, mixing uniformly, and removing precipitation part through standing and second separation so as to obtain bioactive protein solution; removing alcohol and salinity, and drying through post-processing to the bioactive protein solution, and then obtaining the natural bioactive protein. The method provided by the invention adopts two food-grade raw materials of sodium chloride and alcohol, and can be used for extracting the natural bioactive protein from the unpolished rice or / and rice bran, the cost is low, and zero contamination is achieved; the natural bioactive protein prepared by the invention can be used for preparing health foods, taken as food additives and applied to cosmetics, and has a wide application prospect.

The invention discloses a method for preparing a biological activity micro-arc oxidation ceramic coating with a macroscopic / microcosmic double-stage pore structure on the surface of medical titanium through a two-step method, relates to a method for preparing micro-arc oxidation ceramic coating, and solves the problems that a conventional method for preparing double-stage pore micro-arc oxidation ceramic coating is more complicated in preparation process, and the prepared coating has no biological activity. The method comprises the following steps: first, carrying out surface pretreatment on a titanium slab sample, then, placing the pretreated titanium slab sample in sodium nitrate containing micro-arc oxidation electrolyte to be primarily oxidized, next, replacing the oxidized sample in silicon-calcium-phosphate-sodium electrolyte to be secondarily oxidized, washing for 3-5 times, and drying to obtain the biological activity micro-arc oxidation ceramic coating generated on the surface of the titanium slab. The invention can be applicable to the preparation of the biological activity micro-arc oxidation ceramic coating with the macroscopic / microcosmic double-stage pore structure on the surface of medical titanium.

The invention discloses biological ink for 3D printing. The biological ink for 3D printing comprises water-soluble synthetic polymer with the cross-linking function, water-soluble natural polymer with the cross-linking function, bioactive components capable of spontaneously forming special ultrastructures, cross-linking initiator and solvents and further comprises bioactive components. The biological ink for 3D printing overcomes the defects that traditional 3d printing ink is single in component structure, does not have good biological activity and needs to utilize organic solvents, and it is difficult to take cell compatibility, biological activity and mechanical properties into consideration, the biological ink which has biological activity and the fast curing function at the same time and can form a certain microstructure is obtained, and hydrogel obtained through curing of the ink has controllable mechanical properties, good structural stability and a good fidelity effect.

The invention provides an artificial joint with a micro-nano graded topological surface structure and a preparation method of the artificial joint. The artificial joint is formed by compounding a titanium alloy substrate, a micro-porous titanium dioxide surface layer prepared by a micro-arc oxidization method, and a zinc oxide nano rod or a nano taper deposited and grown on the hole wall of the surface, namely the micro-porous titanium dioxide biological activity surface layer is obtained on the surface of an artificial joint titanium substrate through the micro-arc oxidization method; and furthermore, electric depositing parameters are adjusted and a zinc oxide nano rod / taper is deposited and prepared on the titanium dioxide biological activity surface layer, so as to form the artificial joint with the micro-nano graded topological surface structure. The artificial joint can utilize abundant titanium dioxide micron hole structures on the surface and a zinc oxide nano topological structure deposited and grown in the hole wall to enhance the biological effects of adhesion, growth, multiplication and the like of surface osteoblast, and realize the slow release of the element zinc; and therefore, the antibacterial capability, the biological activity, the biocompatibility and the cell regulating and controlling capability of the surface at an implantation initial stage are greatly improved.

The invention relates to a biologically active porous polyetheretherketone material and its preparation method and application. The pore diameter of the active porous polyether ether ketone material is 450-800 μm, the porosity is 30-95%, and the inner surface of the pores contains hydroxyapatite microspheres. First, hydroxyapatite microspheres are evenly adhered to the surface of NaCl particles, and then sintered to obtain composite porogenic particles, then the composite porogenic particles and polyether ether ketone are mixed uniformly, compacted and sintered, and finally NaCl is removed to obtain porous polystyrene Ether ether ketone material. The material can be loaded with bone-promoting drugs and antibacterial drugs as needed. The addition of hydroxyapatite microspheres on the inner surface can not only effectively improve the biological inertia of polyetheretherketone, making it biologically active, but also capable of loading drugs and Growth factor, and has a good slow-release effect, and plays a good role in promoting osteogenesis and antibacterial performance. The invention has the advantages of simple process, low cost, controllable structure, convenient drug loading and the like.

The invention provides a multi-biologically active modified lignin self-assembled drug-loaded nano-micelle, which is prepared from acylated lignin modified by an acid anhydride and then modified by a biologically active compound. Bioactive compounds have a variety of biological activities. Lignin is prepared by acylation, esterification and other reactions to prepare lignin-grafted bioactive compounds, which are then prepared into nanomicelles. The nanomicelles are good drug carriers and also have lignin and Various biological activities of biologically active compounds; the biologically active compounds of the present invention are linked together with lignin through chemical bonds, and the amphiphilic nature of lignin is used to self-assemble into nano-micelles, which can greatly improve the utilization rate of biologically active compounds; The introduction of a hydrophobic unit of a biologically active compound on the base can greatly improve the drug-carrying capacity of the nanomicelles for hydrophobic drugs. The invention also provides a preparation method of the above-mentioned multi-biologically active modified lignin self-assembled drug-loading nano-micelles, which has the advantages of simplified process and good drug-loading capacity of the micelles.