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A kind of bioactive porous polyetheretherketone and its preparation method and application

A polyetheretherketone and bioactive technology, which is applied in the field of bioactive porous polyetheretherketone materials and their preparation, can solve the problems of lack of osteoconductive and osseointegration properties, application limitations, etc., and achieve good sustained-release effect and drug loading. Convenience and good antibacterial activity

Active Publication Date: 2022-04-22
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the bioinert and hydrophobic surface of PEEK itself limits its application in the field of orthopedic implants. Bioinert PEEK materials do not have good osteoconduction (Osteoconduction) and osseointegration (Osseointegration) performance, as bone implant materials After being implanted in the body, it does not respond well to the surrounding bone tissue and is tightly combined with the bone. On the contrary, a layer of fibrous tissue will be produced to wrap the PEEK implant material

Method used

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  • A kind of bioactive porous polyetheretherketone and its preparation method and application
  • A kind of bioactive porous polyetheretherketone and its preparation method and application
  • A kind of bioactive porous polyetheretherketone and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0039] (1) All the raw materials in the example are commercially available. Screen 450 μm ~ 800 μm NaCl particles and 1 μm ~ 20 μm hydroxyapatite microspheres, and wet the surface of NaCl particles according to the mass ratio of 100:3 to make hydroxyapatite Stone microspheres are evenly adhered to the surface of NaCl particles and sintered at 700°C for 2 hours to construct composite porogenic particles;

[0040](2) Mix the composite porogenic particles and PEEK powder uniformly according to the mass ratio of 6:1, compact under the pressure of 10MPa, sinter at 380°C for 30min, soak in deionized water at 60°C for 4h, and then the active porous polyetheretherketone can be obtained The materials were ultrasonically cleaned with distilled water, placed in an oven at 60°C for 3 hours, and stored for later use;

[0041] (3) The porosity of the active porous polyetheretherketone is 82%, the compressive yield strength is 1.52MPa, and the compressive modulus is 54.3MPa;

[0042] (4) Pr...

Embodiment 2

[0045] (1) Screen 450 μm ~ 800 μm NaCl particles and 1 μm ~ 20 μm hydroxyapatite microspheres, and wet the surface of NaCl particles according to the mass ratio of 100:3, so that the hydroxyapatite microspheres evenly adhere to the NaCl particles On the surface, sinter at 700°C for 2 hours to construct composite porogenic particles;

[0046] (2) Mix the composite porogenic particles and PEEK powder uniformly according to the mass ratio of 6:1, compact under the pressure of 10MPa, sinter at 380°C for 30min, soak in deionized water at 60°C for 4h, and then the active porous polyetheretherketone can be obtained The materials were ultrasonically cleaned with distilled water, placed in an oven at 60°C for 3 hours, and stored for later use;

[0047] (3) The porosity of the active porous polyetheretherketone is 82%, the compressive yield strength is 1.52MPa, and the compressive modulus is 54.3MPa;

[0048] (4) Prepare 10mg / ml BMP-2 solution, keep the negative pressure adsorption at ...

Embodiment 3

[0051] (1) Screen 450 μm ~ 800 μm NaCl particles and 1 μm ~ 20 μm hydroxyapatite microspheres, and wet the surface of NaCl particles according to the mass ratio of 100:3, so that the hydroxyapatite microspheres evenly adhere to the NaCl particles On the surface, sinter at 700°C for 2 hours to construct composite porogenic particles;

[0052] (2) Mix the composite porogenic particles and PEEK powder uniformly according to the mass ratio of 6:1, compact under the pressure of 10MPa, sinter at 380°C for 30min, soak in deionized water at 60°C for 4h, and then the active porous polyetheretherketone can be obtained The materials were ultrasonically cleaned with distilled water, placed in an oven at 60°C for 3 hours, and stored for later use;

[0053] (3) The porosity of the active porous polyetheretherketone is 82%, the compressive yield strength is 1.52MPa, and the compressive modulus is 54.3MPa;

[0054] (4) Prepare icariin solution of 10mg / ml, keep the negative pressure adsorptio...

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Abstract

The invention relates to a biologically active porous polyetheretherketone material and its preparation method and application. The pore diameter of the active porous polyether ether ketone material is 450-800 μm, the porosity is 30-95%, and the inner surface of the pores contains hydroxyapatite microspheres. First, hydroxyapatite microspheres are evenly adhered to the surface of NaCl particles, and then sintered to obtain composite porogenic particles, then the composite porogenic particles and polyether ether ketone are mixed uniformly, compacted and sintered, and finally NaCl is removed to obtain porous polystyrene Ether ether ketone material. The material can be loaded with bone-promoting drugs and antibacterial drugs as needed. The addition of hydroxyapatite microspheres on the inner surface can not only effectively improve the biological inertia of polyetheretherketone, making it biologically active, but also capable of loading drugs and Growth factor, and has a good slow-release effect, and plays a good role in promoting osteogenesis and antibacterial performance. The invention has the advantages of simple process, low cost, controllable structure, convenient drug loading and the like.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a bioactive porous polyether ether ketone material and its preparation method and application. The inner surface of the material has an active hydroxyapatite layer, which can be loaded by adsorption Osteogenic drugs and antibacterial drugs are mainly used in artificial bone repair and bone transplantation. Background technique [0002] Polyetheretherketone (poly-ether-ether-ketone, referred to as PEEK), as a special engineering plastic with excellent performance, is widely used in trauma, prosthesis, orthopedic implants and other medical fields. Compared with titanium alloy and stainless steel, etc. Traditional metal implants, PEEK has good biological properties. As early as 20 years ago, the biocompatibility of polyether ether ketone was proved. No cytotoxicity was found in the process of co-cultivation of cells. Its biological Security is well guaranteed. Moreover, PEEK ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/32A61L27/56A61L27/54C08J9/26C08L61/16
CPCA61L27/18A61L27/32A61L27/56A61L27/54C08J9/26C08J2361/16C08J2201/0444A61L2300/404A61L2300/412A61L2300/602C08L61/16
Inventor 张立群谢纹奇石锐吴丝竹路欣
Owner BEIJING UNIV OF CHEM TECH
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