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Preparation method of bioactive polylactic acid its product and application

A technology of biological activity and bioactive substances, which is applied in the field of preparation of modified polylactic acid, can solve the problems that the amount and position cannot be adjusted arbitrarily, the molecules are easy to fall off, and the bioactivation modification of polylactic acid is beneficial to achieve specific effects, Good biocompatibility, the effect of hydrolysis pH overcoming

Inactive Publication Date: 2006-05-10
潘君
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Physical methods can improve the surface bioactivity, hydrophilicity / hydrophobicity and other properties of materials to a certain extent, but there may often be the following problems: ①The blending is not uniform, so that the properties of the contact surface between the material and the cells are not uniform , resulting in different growth states of cells on the material; ②Physical adsorption method usually maintains the interaction between the adsorbed molecules and the polylactic acid material by van der Waals force, the binding force is weak, and the adsorbed molecules are easy to fall off, thus affecting the biological activity of the material
Through the active group at the end of the polylactic acid chain, biologically active substances can be introduced into the polylactic acid material, but it can only be introduced at the chain end of the polylactic acid, and the amount and position of the introduction cannot be adjusted arbitrarily
At present, there is no domestic research on the bioactivation modification of polylactic acid by chemical methods.

Method used

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  • Preparation method of bioactive polylactic acid its product and application
  • Preparation method of bioactive polylactic acid its product and application

Examples

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Effect test

Embodiment 1

[0031] Example 1: Take 100 grams of raw materials and adopt 10% by weight of maleic anhydride-modified polylactic acid (MPLA), dissolve in 400 ml of THF, add this solution to 12 grams of methylolamine, and react at room temperature for 10 minutes , the product was separated, purified and dried, and then dissolved in 400ml of THF (tetrahydrofuran) / DMF (dimethylformamide) (3:1) mixed solvent, 25 grams of polyethylene glycol with a molecular weight of 1000 and 8 grams of 1 , 6-hexamethylene diisocyanate (HDI) was dissolved in the mixed solvent, the three components were mixed uniformly and reacted at 60 ° C for 2 hours. After the product was separated and purified, it was dissolved in the mixed solvent. 50 grams of galactose (a sugar substance that can be recognized by liver tissue) was reacted at 60° C. for 2 hours, and the product was polylactic acid grafted with galactose.

Embodiment 2

[0032] Embodiment 2: get 100 grams of raw materials and adopt the maleic anhydride modified polylactic acid (MPLA) of 5% by weight, dissolve in 400ml THF, then add this solution to distilled water, collect precipitation in 8 hours, and use it again after drying. 400ml of THF was dissolved. 14 grams of N-hydroxysuccinimide and 5 grams of DCC were added to react at 0°C for 2 hours and then placed at room temperature for 20 hours. cancer drug, acting on chronic myeloid leukemia), reacting at room temperature for 20 hours to obtain a product, which is a polymerized antineoplastic acid after separation and purification.

Embodiment 3

[0033] Example 3: Take 100 grams of raw materials and adopt 15% by weight of maleic anhydride-modified polylactic acid (MPLA), dissolve in 400 ml of THF, add 35 grams of butanediamine, react at room temperature for 60 minutes, and the product is separated, purified and dried Then, use 400ml of THF / DMF (3:1) mixed solvent to dissolve, and then use 50ml and 100ml of this mixed solvent to dissolve 30 grams of DCC and 300 grams of hydrolyzed collagen respectively. Mix the three components evenly and react at -20°C for 24 hours. hours, and react at room temperature for 24 hours to obtain a reaction product, which is a polylactic acid modified by hydrolyzed collagen after separation and purification.

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Abstract

A process for preparing a bioactive polylactic acid from the maleic acid anhydride modified polylactic acid includes directly adding organic diamine, diol, hydroxyamine, or water, reacting, separating and purifying the resultant, adding polyethanediol and bioactive substance, and reacting under action of organic cross-linking agent to obtain target product. The target product can be used as the scaffold of tissue engineery and the slow-releasing target carrier of medicine.

Description

technical field [0001] The present invention relates to a preparation method of bioactive polylactic acid, more precisely, the present invention relates to a preparation method of further modified polylactic acid on the basis of maleic anhydride modified polylactic acid by using bioactive substances as raw materials , and its products and applications. Background technique [0002] (1) Research on polylactic acid and its chemical modification [0003] The outstanding advantages of polylactic acid materials are that they have good biocompatibility, degradability and relatively moderate mechanical properties. The product of its hydrolysis in vivo or in vitro is biometabolizable lactic acid, which is finally decomposed into carbon dioxide and water. A synthetic polymer material approved by the US FDA for use in vivo. Due to its excellent properties, polylactic acid is an excellent environmentally friendly material and is favored by environmental protection workers; more promi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/91A61K47/34A61K31/74A61L31/16
Inventor 潘君王远亮
Owner 潘君
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