Strontium-containing xenogeneic bone scaffold and preparation method thereof

A bone scaffold and xenogeneic technology, applied in the field of materials, can solve the problems of long preparation period and limited strontium content, and achieve the effects of prolonging the release period, easy operation and short period

Inactive Publication Date: 2017-05-31
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for heterogeneous bone scaffolds, since the scaffolds are calcined from ready-made animal bones, it is difficult to introduce strontium through element substitution later.
A few studies have attempted to introduce strontium ions into autologous bone scaffolds by ion exchange, but the preparation cycle is lengthy (at least 2 weeks), and the amount of strontium loaded is limited

Method used

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  • Strontium-containing xenogeneic bone scaffold and preparation method thereof
  • Strontium-containing xenogeneic bone scaffold and preparation method thereof
  • Strontium-containing xenogeneic bone scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] a) Select porcine femoral cancellous bone, cut into pieces, stir in 80°C water, and change the liquid every 3 hours. When the aqueous solution was bloodless, the bones were transferred to 75% (v / v) ethanol and stirred for 4 hours. The bones were then stirred in 10% (w / v) sodium hydroxide for 2 h. Finally the bones were stirred in 30% (v / v) hydrogen peroxide for 12h. The bone was washed with water, calcined at 800°C for 5 hours, and the heterogeneous bone scaffold was obtained after cooling.

[0042] b) Preparation of SrCl 2 Aqueous solution (2M), soak the scaffold in it, stir for 6 hours, absorb excess liquid, bake at 60°C for 2 hours, and obtain the heterogeneous bone / Sr scaffold.

[0043] c) Prepare an organic solution of polycaprolactone (PCL) in dichloromethane (DCM) (10%, w / v), and coat the organic solution on the heterogeneous bone / Sr scaffold. After the DCM was volatilized, it was heated at 60°C for 2 hours, and after cooling, the heterogeneous bone / Sr / PCL sc...

Embodiment 2

[0050] Select porcine femoral cancellous bone, cut into pieces, stir in 80°C water, and change the liquid every 3 hours. When the aqueous solution was bloodless, the bones were transferred to 75% (v / v) ethanol and stirred for 4 hours. The bones were then stirred in 10% (w / v) sodium hydroxide for 2 h. Finally the bones were stirred in 30% (v / v) hydrogen peroxide for 12h. The bone was washed with water, calcined at 800°C for 5 hours, and the heterogeneous bone scaffold was obtained after cooling. Prepare SrCl 2 Aqueous solution (2M), soak the scaffold in it, stir for 6 hours, absorb excess liquid, bake at 60°C for 2 hours, and obtain the heterogeneous bone / Sr scaffold. An organic solution of polycaprolactone (PCL) in dichloromethane (DCM) (15%, w / v) was prepared, and the organic solution was coated on the xenograft bone / Sr scaffold. After the DCM was volatilized, it was heated at 60°C for 3 hours, and after cooling, the heterogeneous bone / Sr / PCL scaffold was obtained and sto...

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Abstract

The invention provides a strontium-containing xenogeneic bone scaffold. The bone scaffold comprises a strontium-ion-loaded xenogeneic bone scaffold body and a polymer biological material surface coating. The good porosity characteristic of the xenogeneic bone scaffold body is used, firstly, strontium is adsorbed on the surface of the scaffold body, and then the surface of the scaffold body is coated with a polymer biological material to protect strontium. Strontium can be loaded in the xenogeneic bone scaffold body quickly, the residence time and release period of strontium on the scaffold body can also be prolonged, and it is hopeful to improve the bone repair effect of traditional xenogeneic bone scaffolds.

Description

technical field [0001] The invention relates to the field of material technology, in particular to a strontium-containing heterogeneous bone scaffold and a preparation method thereof. Background technique [0002] Bone defect is one of the most common clinical diseases. Bone defects that exceed a critical size do not heal on their own and require surgical intervention. Autologous bone grafting is the best way to treat bone defects. However, autologous bone requires secondary surgery to obtain from other parts of the patient, which adds pain to the patient and increases the risk of morbidity. Therefore, people continue to seek autologous bone substitutes. Among them, xenogeneic bone scaffolds derived from animals present a promising application prospect. [0003] Xenogeneic bone scaffolds are generally deproteinized and calcined animal bones, which have a natural porous structure that allows cells to grow in and survive. Moreover, the heterogeneous bone scaffold is mainly...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/04A61L27/34A61L27/56A61L27/54
CPCA61L27/3608A61L27/047A61L27/34A61L27/365A61L27/54A61L27/56A61L2300/102A61L2300/412A61L2430/02C08L67/04
Inventor 程德林梁青飞阮长顺潘浩波范家辉
Owner SHENZHEN INST OF ADVANCED TECH
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