Nano-composite material and preparation method thereof used for tissue repair

A nanocomposite material and tissue repair technology, applied in the field of biomedical nanomaterials, can solve the problems of poor mechanical properties, short conjugated structure and limitations of block copolymers, and achieve improved mechanical properties, good biocompatibility, increased active effect

Inactive Publication Date: 2010-06-02
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent document ZL200610016950.9 discloses a block copolymer of aniline oligomer and aliphatic polyester and its preparation method. With excellent solubility, although the introduced aniline oligomer cannot be biodegraded, it can be excreted through the kidneys due to its short conjugated structure
However, the block copolymer has poor mechanical properties and is limited when applied to the repair of hard tissues

Method used

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  • Nano-composite material and preparation method thereof used for tissue repair
  • Nano-composite material and preparation method thereof used for tissue repair
  • Nano-composite material and preparation method thereof used for tissue repair

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preparation example Construction

[0037] The invention also discloses a method for preparing a nanocomposite material for tissue repair, including:

[0038] a) dissolving conventional tissue repair materials in a solvent, then adding nano-hydroxyapatite to the solvent, and stirring evenly to obtain a matrix material;

[0039] The conventional tissue repair material is polylactide-glycolide, polylactide or polycaprolactone;

[0040] b) dissolving the block copolymer in a solvent, then adding it to the matrix material obtained in step a), mixing uniformly, settling, removing the solvent, and obtaining a nanocomposite material;

[0041] The block copolymer is a block copolymer of aliphatic polyester and aniline oligomer.

[0042] According to the present invention, firstly, conventional tissue repair materials and nano-hydroxyapatite are used as raw materials, and the raw materials are dissolved in a solvent and stirred thoroughly to prepare matrix materials. The solvent is preferably chloroform. The conventio...

Embodiment 1

[0061] Dissolve 85.9 mg of PLGA in chloroform at room temperature, stir, and slowly add 14 mg of nano-hydroxyapatite after fully dissolving, and fully stir to obtain a matrix solution;

[0062] Dissolving 0.1 mg of a block copolymer of aliphatic polyester and aniline oligomer in chloroform, then adding it to the matrix solution, performing magnetic stirring, ultrasonic oscillation, and settling in absolute ethanol to obtain a solid composite material; Then place it in a fume hood to evaporate the solvent, extract it with a vacuum pump, remove the residual solvent, and prepare a nanocomposite material (PAP / op-HA / PLGA) for tissue repair;

[0063] In the PAP / op-HA / PLGA, the weight percentage of the block copolymer is 0.1%.

Embodiment 2

[0065] Dissolve 85mg of PLGA in chloroform at room temperature, stir, and slowly add 14mg of nano-hydroxyapatite after fully dissolving, and fully stir to obtain a matrix solution;

[0066]Dissolving 1 mg of a block copolymer of aliphatic polyester and aniline oligomer in chloroform, then adding it to the matrix solution, performing magnetic stirring, ultrasonic oscillation, and settling in absolute ethanol to obtain a solid composite material; then Place in a fume hood to evaporate the solvent, extract with a vacuum pump to remove residual solvent, and prepare a nanocomposite material (PAP / op-HA / PLGA) for tissue repair;

[0067] In the PAP / op-HA / PLGA, the weight percentage of the block copolymer is 1%.

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Abstract

The invention discloses a nano-composite material used for tissue repair, which comprises segmented copolymer with electrical activity, nano-hydroxyapatite and normal tissue repair materials; wherein the segmented copolymer comprises aliphatic polyester and ailine pentamer, and the normal tissue repair materials comprises poly (lactide-co-glycolide), polylactide or polycaprolactone. The invention also discloses a preparation method of the nano-composite materials used for tissue repair, which comprises the following steps of: (a) dissolving the normal tissue repair material in a solvent, then adding the nano-hydroxyapatite into the solvent, and uniformly stirring to obtain a substrate material; and (b) dissolving the segmented copolymer into the solvent, then adding to the substrate material and mixing uniformly, and then precipitating and removing the solvent. The nano-composite material used for the tissue repair has the advantages of nontoxicity, biodegradability, processibility, sufficient mechanical strength, favorable electrical activity, and biocompatibility.

Description

technical field [0001] The invention relates to the technical field of biomedical nanomaterials, in particular to a nanocomposite material for tissue repair and a preparation method thereof. Background technique [0002] After the human body is injured, it often causes tissue damage, fracture and defect, and even causes bleeding and infection. Normally, the tissue in the damaged area can heal and repair naturally. Tissue repair is manifested as tissue regeneration, which is mainly achieved through cell behaviors such as cell growth, migration, differentiation, and matrix secretion. These cell behaviors are all related to cell signal transduction, including chemical signals to realize the information transfer between cells and electrical signals that affect the information transfer between cells and cells. However, due to the disorder or interruption of signal conduction in the damaged tissue, the regeneration ability of the damaged tissue is reduced, and it is difficult fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/58
Inventor 章培标于婷陈学思邬海涛王宇崔立国庄秀丽崔巍巍徐洋王宗良
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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